Glucagon-like peptide 2 receptor

Glucagon-like peptide 2 receptor
Identifiers
Symbol(s)	GLP2R;
External IDs	OMIM: 603659 MGI: 2136733 Homologene: 3132
Gene ontology Molecular Function: • receptor activity • G-protein coupled receptor activity Cellular Component: • plasma membrane • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, coupled to cAMP nucleotide second messenger • positive regulation of cell proliferation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	9340	93896
Ensembl	ENSG00000065325	na
Uniprot	O95838	na
Refseq	NM_004246 (mRNA) NP_004237 (protein)	XM_991784 (mRNA) XP_996878 (protein)
Location	Chr 17: 9.67 - 9.73 Mb	na
Pubmed search	[1]	[2]

The gene for the glucagon-like peptide 2 receptor (GLP-2) is on chromosome 17.

See also

• Glucagon-like peptide-2

Further reading

• Burrin DG, Petersen Y, Stoll B, Sangild P (2001). "Glucagon-like peptide 2: a nutrient-responsive gut growth factor.". J. Nutr. 131 (3): 709-12. PMID 11238747.
• Munroe DG, Gupta AK, Kooshesh F, et al. (1999). "Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1569-73. PMID 9990065.
• Yusta B, Huang L, Munroe D, et al. (2000). "Enteroendocrine localization of GLP-2 receptor expression in humans and rodents.". Gastroenterology 119 (3): 744-55. PMID 10982769.
• Thulesen J, Knudsen LB, Hartmann B, et al. (2002). "The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist.". Regul. Pept. 103 (1): 9-15. PMID 11738243.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Koehler JA, Yusta B, Drucker DJ (2005). "The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.". Mol. Endocrinol. 19 (2): 459-73. doi:10.1210/me.2004-0196. PMID 15471943.
• Ørskov C, Hartmann B, Poulsen SS, et al. (2005). "GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.". Regul. Pept. 124 (1-3): 105-12. doi:10.1016/j.regpep.2004.07.009. PMID 15544847.
• Mahon MJ, Shimada M (2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803-7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850.
• Estall JL, Koehler JA, Yusta B, Drucker DJ (2005). "The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.". J. Biol. Chem. 280 (23): 22124-34. doi:10.1074/jbc.M500078200. PMID 15817468.
• Guan X, Karpen HE, Stephens J, et al. (2006). "GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.". Gastroenterology 130 (1): 150-64. doi:10.1053/j.gastro.2005.11.005. PMID 16401478.
• Sams A, Hastrup S, Andersen M, Thim L (2006). "Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines.". Eur. J. Pharmacol. 532 (1-2): 18-23. doi:10.1016/j.ejphar.2005.12.001. PMID 16448646.

External links

• IUPHAR GPCR Database - GLP-2 receptor
• MeSH glucagon-like+peptide+receptor