Melanin-concentrating hormone receptor 2: Difference between revisions

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{{Infobox gene}}
{{PBB_Controls
'''Melanin-concentrating hormone receptor 2''' ('''MCH<sub>2</sub>''') also known as '''G-protein coupled receptor 145''' ('''GPR145''') is a [[protein]] that in humans is encoded by the ''MCHR2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84539| accessdate = }}</ref><ref name="pmid11355873">{{cite journal |vauthors=Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M | title = Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor | journal = Biochem. Biophys. Res. Commun. | volume = 283 | issue = 5 | pages = 1013–8 |date=May 2001 | pmid = 11355873 | doi = 10.1006/bbrc.2001.4893 }}</ref><ref name="pmid11274220">{{cite journal |vauthors=Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI | title = Molecular cloning and functional characterization of MCH2, a novel human MCH receptor | journal = J. Biol. Chem. | volume = 276 | issue = 23 | pages = 20125–9 |date=June 2001 | pmid = 11274220 | doi = 10.1074/jbc.M102068200 }}</ref>
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MCH<sub>2</sub> is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH<sub>2</sub> gene and its receptor product.
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Melanin-concentrating hormone receptor 2
| HGNCid = 20867
| Symbol = MCHR2
| AltSymbols =; MCH2; GPR145; MCH2R; SLT
| OMIM = 606111
| ECnumber = 
| Homologene = 50004
| MGIid = 
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84539
    | Hs_Ensembl = ENSG00000152034
    | Hs_RefseqProtein = NP_001035269
    | Hs_RefseqmRNA = NM_001040179
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 100474507
    | Hs_GenLoc_end = 100548820
    | Hs_Uniprot = Q969V1
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Melanin-concentrating hormone receptor 2''', also known as '''MCHR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84539| accessdate = }}</ref>


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==Clinical significance==
{{PBB_Summary
Treatment of human cells expressing MCHR2 with [[Melanin concentrating hormone|MCH]] resulted in upregulation of [[IDH3A]], [[PCK1]] and [[PFKFB4]] and the downregulation of [[INSIG2]] and [[ACOT8]].<ref name="pmid20340065">{{cite journal |vauthors=Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ | title = Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction | journal = Horm. Metab. Res. | volume = 42 | issue = 7 | pages = 521–7 |date=June 2010 | pmid = 20340065 | doi = 10.1055/s-0030-1249019 }}</ref>
| section_title =  
| summary_text =  
}}


==See also==
==See also==
Line 57: Line 11:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2999 | title = Melanin-Concentrating Hormone Receptors: MCH<sub>2</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Hill J, Duckworth M, Murdock P, ''et al.'' |title=Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20125-9 |year= 2001 |pmid= 11274220 |doi= 10.1074/jbc.M102068200 }}
*{{cite journal   |vauthors=Sailer AW, Sano H, Zeng Z, etal |title=Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7564–9 |year= 2001 |pmid= 11404457 |doi= 10.1073/pnas.121170598 | pmc=34708 }}
*{{cite journal  | author=Mori M, Harada M, Terao Y, ''et al.'' |title=Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 5 |pages= 1013-8 |year= 2001 |pmid= 11355873 |doi= 10.1006/bbrc.2001.4893 }}
*{{cite journal   |vauthors=An S, Cutler G, Zhao JJ, etal |title=Identification and characterization of a melanin-concentrating hormone receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7576–81 |year= 2001 |pmid= 11416225 |doi= 10.1073/pnas.131200698 | pmc=34710 }}
*{{cite journal  | author=Sailer AW, Sano H, Zeng Z, ''et al.'' |title=Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7564-9 |year= 2001 |pmid= 11404457 |doi= 10.1073/pnas.121170598 }}
*{{cite journal   |vauthors=Wang S, Behan J, O'Neill K, etal |title=Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34664–70 |year= 2001 |pmid= 11459838 |doi= 10.1074/jbc.M102601200 }}
*{{cite journal | author=An S, Cutler G, Zhao JJ, ''et al.'' |title=Identification and characterization of a melanin-concentrating hormone receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7576-81 |year= 2001 |pmid= 11416225 |doi= 10.1073/pnas.131200698 }}
*{{cite journal   |vauthors=Bednarek MA, Feighner SD, Hreniuk DL, etal |title=Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9379–86 |year= 2001 |pmid= 11478907 |doi=10.1021/bi010867p }}
*{{cite journal | author=Wang S, Behan J, O'Neill K, ''et al.'' |title=Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34664-70 |year= 2001 |pmid= 11459838 |doi= 10.1074/jbc.M102601200 }}
*{{cite journal   |vauthors=Bednarek MA, Tan C, Hreniuk DL, etal |title=Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13821–6 |year= 2002 |pmid= 11839762 |doi= 10.1074/jbc.M200563200 }}
*{{cite journal | author=Bednarek MA, Feighner SD, Hreniuk DL, ''et al.'' |title=Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9379-86 |year= 2001 |pmid= 11478907 |doi=  }}
*{{cite journal   |vauthors=Audinot V, Lahaye C, Suply T, etal |title=SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 841–8 |year= 2002 |pmid= 12127971 |doi=10.1016/S0006-291X(02)00763-5  }}
*{{cite journal | author=Bednarek MA, Tan C, Hreniuk DL, ''et al.'' |title=Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13821-6 |year= 2002 |pmid= 11839762 |doi= 10.1074/jbc.M200563200 }}
*{{cite journal   |vauthors=Logan DW, Bryson-Richardson RJ, Pagán KE, etal |title=The structure and evolution of the melanocortin and MCH receptors in fish and mammals. |journal=Genomics |volume=81 |issue= 2 |pages= 184–91 |year= 2003 |pmid= 12620396 |doi=10.1016/S0888-7543(02)00037-X  }}
*{{cite journal | author=Audinot V, Lahaye C, Suply T, ''et al.'' |title=SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 841-8 |year= 2002 |pmid= 12127971 |doi= }}
*{{cite journal  |vauthors=Vitale RM, Pedone C, De Benedetti PG, Fanelli F |title=Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations. |journal=Proteins |volume=56 |issue= 3 |pages= 430–48 |year= 2004 |pmid= 15229878 |doi= 10.1002/prot.20125 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hawes BE, Green B, O'Neill K, etal |title=Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. |journal=Obes. Res. |volume=12 |issue= 8 |pages= 1327–34 |year= 2004 |pmid= 15340116 |doi=10.1038/oby.2004.167  }}
*{{cite journal | author=Logan DW, Bryson-Richardson RJ, Pagán KE, ''et al.'' |title=The structure and evolution of the melanocortin and MCH receptors in fish and mammals. |journal=Genomics |volume=81 |issue= 2 |pages= 184-91 |year= 2003 |pmid= 12620396 |doi=  }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Vitale RM, Pedone C, De Benedetti PG, Fanelli F |title=Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations. |journal=Proteins |volume=56 |issue= 3 |pages= 430-48 |year= 2004 |pmid= 15229878 |doi= 10.1002/prot.20125 }}
*{{cite journal | author=Hawes BE, Green B, O'Neill K, ''et al.'' |title=Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. |journal=Obes. Res. |volume=12 |issue= 8 |pages= 1327-34 |year= 2004 |pmid= 15340116 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{Neuropeptidergics}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
[[Category:Human proteins]]
 
 
{{transmembranereceptor-stub}}

Revision as of 17:33, 30 October 2017

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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Ensembl

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Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.[1][2][3]

MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.

Clinical significance

Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.[4]

See also

References

  1. ↑ "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2".
  2. ↑ Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M (May 2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.
  3. ↑ Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI (June 2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.
  4. ↑ Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ (June 2010). "Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction". Horm. Metab. Res. 42 (7): 521–7. doi:10.1055/s-0030-1249019. PMID 20340065.

External links

Further reading


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