Flupentixol
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| Image:Flupenthixol.png | |
| Flupentixol
| |
| Systematic (IUPAC) name | |
| 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene] propyl]piperazin-1-yl]ethanol | |
| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C23H25F3N2OS |
| Mol. mass | 434.519 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 19 to 39 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
℞ Prescription only |
| Routes | intramuscular, Oral |
Flupentixol (marketed as Depixol and Fluanxol) is a typical antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. This drug combines piperazine with the chemical thioxanthene with three fluorine atoms molecularly bonded to it.
Its main use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. In some countries this can be involuntary under Community Treatment Orders.
Mode of action
Flupentixol is a type of thioxanthene drug and acts by antagonism of D1 and D2 dopamine receptors (as well as serotonin). Side effects are similar to many other typical antipsychotics, namely extrapyramidal symptoms of akathisia, parkinsonian tremor and rigidity.
The typical antipsychotics are less commonly used now that the atypical antipsychotics are available (with less side effects). However flupentixol decanoate ester is useful in patients who are likely to be non-compliant. This formulation is given as an intramuscular depot injection lasting up to 3 weeks from a single injection.
Psycholeptics: antipsychotics (N05A) | |
|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine) |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
