Lipotropin
| proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
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| Identifiers | |
| Symbol | POMC |
| Entrez | 5443 |
| HUGO | 9201 |
| OMIM | 176830 |
| RefSeq | NM_000939 |
| UniProt | P01189 |
| Other data | |
| Locus | Chr. 2 p23 |
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WikiDoc Resources for Lipotropin | |
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Most recent articles on Lipotropin | |
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Ongoing Trials on Lipotropin at Clinical Trials.gov Clinical Trials on Lipotropin at Google
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US National Guidelines Clearinghouse on Lipotropin
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Patient resources on Lipotropin Discussion groups on Lipotropin Patient Handouts on Lipotropin Directions to Hospitals Treating Lipotropin Risk calculators and risk factors for Lipotropin
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Lipotropin is a hormone produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which undergoes cleavage to adrenocorticotropin (ACTH) and β-lipotropin (β-LPH).
Beta-lipotropin
β-lipotropin is a 90 amino acid polypeptide that stimulates melanocytes to produce melanin, and can also be cleaved into smaller peptides. In humans, γ-lipotropin, α-MSH, β-MSH, γ-MSH, α-endorphin, β-endorphin, γ-endorphin, and met-enkephalin are all possible fragments of β-lipotropin.[1]
β-lipotropin is the carboxy-terminal fragment of POMC, and performs lipid-mobilizing functions such as lipolysis and steroidogenesis.
Gamma-lipotropin
γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids.
External links
References
- ↑ Joachim Spiess, Charles D. Mount, Wendell E. Nicholson, David N. Orth (1982), "NH2-Terminal amino acid sequence and peptide mapping of purified human β-lipotropin: Comparison with previously proposed sequences", Proc. Natl. Acad. Sci. USA 79: 5071-5, <http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=346829&blobtype=pdf>. Retrieved on 2007-06-21
Peptides: neuropeptides | |
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| Hypothalamic | Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin) |
| Gastrointestinal hormones | Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide |
| Other hormones | Vasopressin - Calcitonin - |
| Other | Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide |
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