Lipotropin

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proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
Identifiers
Symbol	POMC
Entrez	5443
HUGO	9201
OMIM	176830
RefSeq	NM_000939
UniProt	P01189
Other data
Locus	Chr. 2 p23

WikiDoc Resources for Lipotropin
Articles
Most recent articles on Lipotropin Most cited articles on Lipotropin Review articles on Lipotropin Articles on Lipotropin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Lipotropin Images of Lipotropin Photos of Lipotropin Podcasts & MP3s on Lipotropin Videos on Lipotropin
Evidence Based Medicine
Cochrane Collaboration on Lipotropin Bandolier on Lipotropin TRIP on Lipotropin
Clinical Trials
Ongoing Trials on Lipotropin at Clinical Trials.gov Trial results on Lipotropin Clinical Trials on Lipotropin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Lipotropin NICE Guidance on Lipotropin NHS PRODIGY Guidance FDA on Lipotropin CDC on Lipotropin
Books
Books on Lipotropin
News
Lipotropin in the news Be alerted to news on Lipotropin News trends on Lipotropin
Commentary
Blogs on Lipotropin
Definitions
Definitions of Lipotropin
Patient Resources / Community
Patient resources on Lipotropin Discussion groups on Lipotropin Patient Handouts on Lipotropin Directions to Hospitals Treating Lipotropin Risk calculators and risk factors for Lipotropin
Healthcare Provider Resources
Symptoms of Lipotropin Causes & Risk Factors for Lipotropin Diagnostic studies for Lipotropin Treatment of Lipotropin
Continuing Medical Education (CME)
CME Programs on Lipotropin
International
Lipotropin en Espanol Lipotropin en Francais
Businness
Lipotropin in the Marketplace Patents on Lipotropin
Experimental / Informatics
List of terms related to Lipotropin

Lipotropin is a hormone produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which undergoes cleavage to adrenocorticotropin (ACTH) and β-lipotropin (β-LPH).

Beta-lipotropin

β-lipotropin is a 90 amino acid polypeptide that stimulates melanocytes to produce melanin, and can also be cleaved into smaller peptides. In humans, γ-lipotropin, α-MSH, β-MSH, γ-MSH, α-endorphin, β-endorphin, γ-endorphin, and met-enkephalin are all possible fragments of β-lipotropin.^[1]

β-lipotropin is the carboxy-terminal fragment of POMC, and performs lipid-mobilizing functions such as lipolysis and steroidogenesis.

Gamma-lipotropin

γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids.

External links

• MeSH beta-Lipotropin
• MeSH gamma-Lipotropin

References

v • d • e Endocrine system: hormones/endocrine glands (Peptide hormones, Steroid hormones)
Hypothalamic-pituitary	Hypothalamus: TRH, CRH , GnRH, GHRH, somatostatin, dopamine - Posterior pituitary: vasopressin, oxytocin - Anterior pituitary: α (FSH, LH, TSH), GH, prolactin, POMC (ACTH, MSH, endorphins, lipotropin)
Adrenal axis	Adrenal medulla: epinephrine, norepinephrine - Adrenal cortex: aldosterone, cortisol, DHEA
Thyroid axis	Thyroid: thyroid hormone (T3 and T4) - calcitonin - Parathyroid: PTH
Gonadal axis	Testis: testosterone, AMH, inhibin - Ovary: estradiol, progesterone, inhibin/activin, relaxin (pregnancy)
Other end. glands	Pancreas: glucagon, insulin, somatostatin - Pineal gland: melatonin
Non-end. glands	Placenta: hCG, HPL, estrogen, progesterone - Kidney: renin, EPO, calcitriol, prostaglandin - Heart atrium: ANP - Stomach: gastrin, ghrelin - Duodenum: CCK, GIP, secretin, motilin, VIP - Ileum: enteroglucagon - Adipose tissue: leptin, adiponectin, resistin - Thymus: Thymosin - Thymopoietin - Thymulin - Skeleton: Osteocalcin - Liver/other: Insulin-like growth factor (IGF-1, IGF-2)
Target-derived	NGF, BDNF, NT-3

v • d • e Peptides: neuropeptides
Hypothalamic	Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin)
Gastrointestinal hormones	Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide
Other hormones	Vasopressin - Calcitonin -
Other	Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide

v • d • e WikiDoc Research Resources for Lipotropin (Click show to right to view)
Articles on Lipotropin	Most recent articles on Lipotropin • Most cited articles on Lipotropin • Review articles on Lipotropin • Articles on Lipotropin in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Lipotropin	Powerpoint slides on Lipotropin • Images of Lipotropin • Photos of Lipotropin • Podcasts & MP3s on Lipotropin • Videos on Lipotropin
Evidence Based Medicine Regarding Lipotropin	Cochrane Collaboration on Lipotropin • Bandolier on Lipotropin • TRIP on Lipotropin
Cost Effectiveness of Lipotropin	Cost Effectiveness of Lipotropin
Clinical Trials Involving Lipotropin	Ongoing Trials on Lipotropin at Clinical Trials.gov • Trial results on Lipotropin • Clinical Trials on Lipotropin at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Lipotropin	US National Guidelines Clearinghouse on Lipotropin • NICE Guidance on Lipotropin • NHS PRODIGY Guidance • FDA on Lipotropin • CDC on Lipotropin
Textbook Information on Lipotropin	Books and Textbook Information on Lipotropin
Pharmacology Resources on Lipotropin	Dosing of Lipotropin • Drug interactions with Lipotropin • Side effects of Lipotropin • Allergic reactions to Lipotropin • Overdose information on Lipotropin • Carcinogenicity information on Lipotropin • Lipotropin in pregnancy • Pharmacokinetics of Lipotropin •
Genetics, Pharmacogenomics, and Proteinomics of Lipotropin	Genetics of Lipotropin • Pharmacogenomics of Lipotropin • Proteomics of Lipotropin
Newstories on Lipotropin	Lipotropin in the news • Be alerted to news on Lipotropin • News trends on Lipotropin
Commentary on Lipotropin	Blogs on Lipotropin
Patient Resources on Lipotropin	Patient resources on Lipotropin • Discussion groups on Lipotropin • Patient Handouts on Lipotropin • Directions to Hospitals Treating Lipotropin • Risk calculators and risk factors for Lipotropin
Healthcare Provider Resources on Lipotropin	Symptoms of Lipotropin • Causes & Risk Factors for Lipotropin • Diagnostic studies for Lipotropin • Treatment of Lipotropin
Continuing Medical Education (CME) Programs on Lipotropin	CME Programs on Lipotropin
International Resources on Lipotropin	Lipotropin en Espanol • Lipotropin en Francais
Business Resources on Lipotropin	Lipotropin in the Marketplace • Patents on Lipotropin
Informatics Resources on Lipotropin	List of terms related to Lipotropin

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .