Jump to: navigation, search

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Normalised absorption spectra of the three human photopsins and of human rhodopsin (dashed).


Photopsins (also known as iodopsins) are the photoreceptor proteins found in the cone cells of the retina that are the basis of color vision. Photopsins are very close analogs of the visual purple rhodopsin that is used in night vision. Photopsins consist of a protein called opsin and a bound chromophore, the retinal.


Opsins are Gn-x protein-coupled receptors of the retinylidene protein family. Isomerization of 11-cis-retinal into all-trans-retinal by light induces a conformational change in the protein that activates photopsin and promotes its binding to G protein transducin, which triggers a second messenger cascade.


Different opsins differ in a few amino acids and absorb light at different wavelengths as retinal-bound pigments.

Cone type Name Range Peak wavelength[1][2]
S (OPN1SW) - "tritan", "cyanolabe" β 400–500 nm 420–440 nm
M (OPN1MW) - "deutan", "chlorolabe" γ 450–630 nm 534–545 nm
L (OPN1LW) - "protan", "erythrolabe" ρ 500–700 nm 564–580 nm

In humans there are three different iodopsins (rhodopsin analogs) that form the protein-pigment complexes photopsin I, II, and III. They are called erythrolabe, chlorolabe, and cyanolabe, respectively.[3] These photopsins have absorption maxima for yellowish-green (photopsin I), green (photopsin II), and bluish-violet light (photopsin III).


George Wald got the 1967 Nobel Prize in Physiology or Medicine for his experiments in the 1950s that showed the difference in absorbance by these photopsins (see image).

See also


  1. Wyszecki, Günther; Stiles, W.S. (1982). Color Science: Concepts and Methods, Quantitative Data and Formulae (2nd ed. ed.). New York: Wiley Series in Pure and Applied Optics. ISBN 0-471-02106-7.  Cite uses deprecated parameter |coauthors= (help)
  2. R. W. G. Hunt (2004). The Reproduction of Colour (6th ed. ed.). Chichester UK: Wiley–IS&T Series in Imaging Science and Technology. pp. 11–12. ISBN 0-470-02425-9. 
  3. Rushton, W. A. H. (1966). "Densitometry of pigments in rods and cones of normal and color defective subjects" (PDF). Investigative Ophthalmology. 5 (3): 233–241. Retrieved 2006-11-14.  Unknown parameter |month= ignored (help)

External links