Endothelin receptor type A

Endothelin receptor type A
Identifiers
Symbol(s)	EDNRA; ETA; ETRA
External IDs	OMIM: 131243 MGI: 105923 Homologene: 1478
Gene ontology Molecular Function: • rhodopsin-like receptor activity • endothelin-A receptor activity • phosphoinositide phospholipase C activity • receptor activity • protein binding Cellular Component: • integral to plasma membrane • membrane Biological Process: • patterning of blood vessels • response to hypoxia • in utero embryonic development • smooth muscle contraction • signal transduction • G-protein coupled receptor protein signaling pathway • adenylate cyclase activation • phospholipase C activation • elevation of cytosolic calcium ion concentration • heart development • respiratory gaseous exchange • cell proliferation • neural crest cell development • glucose transport • negative regulation of cAMP biosynthetic process • vasoconstriction
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1909	13617
Ensembl	ENSG00000151617	ENSMUSG00000031616
Uniprot	P25101	Q61614
Refseq	NM_001957 (mRNA) NP_001948 (protein)	NM_010332 (mRNA) NP_034462 (protein)
Location	Chr 4: 148.62 - 148.69 Mb	Chr 8: 80.56 - 80.62 Mb
Pubmed search	[1]	[2]

Endothelin receptor type A, also known as EDNRA, is a human gene which encodes a G protein-coupled receptor.

See also

• Endothelin receptor

Further reading

• Arai H, Nakao K, Hosoda K, et al. (1993). "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Jpn. Circ. J. 56 Suppl 5: 1303-7. PMID 1291713.
• Hosoda K, Nakao K, Tamura N, et al. (1992). "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor.". J. Biol. Chem. 267 (26): 18797-804. PMID 1326535.
• Hayzer DJ, Rose PM, Lynch JS, et al. (1992). "Cloning and expression of a human endothelin receptor: subtype A.". Am. J. Med. Sci. 304 (4): 231-8. PMID 1415318.
• Hosoda K, Nakao K, Hiroshi-Arai, et al. (1991). "Cloning and expression of human endothelin-1 receptor cDNA.". FEBS Lett. 287 (1-2): 23-6. PMID 1652463.
• Cyr C, Huebner K, Druck T, Kris R (1992). "Cloning and chromosomal localization of a human endothelin ETA receptor.". Biochem. Biophys. Res. Commun. 181 (1): 184-90. PMID 1659806.
• Adachi M, Yang YY, Furuichi Y, Miyamoto C (1991). "Cloning and characterization of cDNA encoding human A-type endothelin receptor.". Biochem. Biophys. Res. Commun. 180 (3): 1265-72. PMID 1719979.
• Lin HY, Kaji EH, Winkel GK, et al. (1991). "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3185-9. PMID 1849646.
• Takigawa M, Sakurai T, Kasuya Y, et al. (1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors.". Eur. J. Biochem. 228 (1): 102-8. PMID 7882989.
• Kobayashi S, Tang R, Wang B, et al. (1994). "Binding and functional properties of endothelin receptor subtypes in the human prostate.". Mol. Pharmacol. 45 (2): 306-11. PMID 8114678.
• Yang H, Tabuchi H, Furuichi Y, Miyamoto C (1993). "Molecular characterization of the 5'-flanking region of human genomic ETA gene.". Biochem. Biophys. Res. Commun. 190 (2): 332-9. doi:10.1006/bbrc.1993.1052. PMID 8427579.
• Elshourbagy NA, Korman DR, Wu HL, et al. (1993). "Molecular characterization and regulation of the human endothelin receptors.". J. Biol. Chem. 268 (6): 3873-9. PMID 8440682.
• Miyamoto Y, Yoshimasa T, Arai H, et al. (1996). "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts.". Biochem. J. 313 ( Pt 3): 795-801. PMID 8611157.
• Horstmeyer A, Cramer H, Sauer T, et al. (1996). "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification.". J. Biol. Chem. 271 (34): 20811-9. PMID 8702836.
• Freedman NJ, Ament AS, Oppermann M, et al. (1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.". J. Biol. Chem. 272 (28): 17734-43. PMID 9211925.
• Bourgeois C, Robert B, Rebourcet R, et al. (1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.". J. Clin. Endocrinol. Metab. 82 (9): 3116-23. PMID 9284755.
• Mao XQ, Gao PS, Roberts MH, et al. (1999). "Variants of endothelin-1 and its receptors in atopic asthma.". Biochem. Biophys. Res. Commun. 262 (1): 259-62. doi:10.1006/bbrc.1999.1158. PMID 10448102.
• Maggi M, Barni T, Fantoni G, et al. (2000). "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons.". J. Clin. Endocrinol. Metab. 85 (4): 1658-65. PMID 10770212.
• Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.". Cell. Mol. Neurobiol. 20 (3): 305-17. PMID 10789830.
• Lee HJ, Chun M, Kandror KV (2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling.". J. Biol. Chem. 276 (20): 16597-600. doi:10.1074/jbc.C000909200. PMID 11262386.
• Paasche JD, Attramadal T, Sandberg C, et al. (2001). "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways.". J. Biol. Chem. 276 (36): 34041-50. doi:10.1074/jbc.M103243200. PMID 11382773.

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub