EDG5

Endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
Identifiers
Symbol(s)	EDG5; AGR16; EDG-5; Gpcr13; H218; LPB2; S1P2; S1PR2
External IDs	OMIM: 605111 MGI: 99569 Homologene: 3118
Gene ontology Molecular Function: • lysosphingolipid and lysophosphatidic acid receptor activity • receptor activity • lipid binding Cellular Component: • membrane • integral to membrane Biological Process: • activation of MAPK activity • signal transduction • G-protein coupled receptor protein signaling pathway • behavior • positive regulation of cell proliferation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	9294	14739
Ensembl	ENSG00000175898	ENSMUSG00000043895
Uniprot	O95136	Q3U5W6
Refseq	NM_004230 (mRNA) NP_004221 (protein)	NM_010333 (mRNA) NP_034463 (protein)
Location	Chr 19: 10.2 - 10.2 Mb	Chr 9: 20.72 - 20.73 Mb
Pubmed search	[1]	[2]

EDG5 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₂.

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation

See also

• Lysophospholipid receptor

Further reading

• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54-60. PMID 10818441.
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496-502. PMID 11915348.
• MacLennan AJ, Browe CS, Gaskin AA, et al. (1994). "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development.". Mol. Cell. Neurosci. 5 (3): 201-9. doi:10.1006/mcne.1994.1024. PMID 8087418.
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.". Biochem. Biophys. Res. Commun. 227 (2): 608-14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
• Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.". J. Biol. Chem. 274 (8): 4626-32. PMID 9988698.
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997-9002. PMID 10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351-8. PMID 10488065.
• An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.". J. Biol. Chem. 275 (1): 288-96. PMID 10617617.
• Himmel HM, Meyer Zu Heringdorf D, Graf E, et al. (2000). "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.". Mol. Pharmacol. 58 (2): 449-54. PMID 10908314.
• Hla T. "Sphingosine 1-phosphate receptors." 64 (1-4): 135-142. PMID 11331101.
• Mazurais D, Robert P, Gout B, et al. (2002). "Cell type-specific localization of human cardiac S1P receptors.". J. Histochem. Cytochem. 50 (5): 661-70. PMID 11967277.
• Osada M, Yatomi Y, Ohmori T, et al. (2003). "Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.". Biochem. Biophys. Res. Commun. 299 (3): 483-7. PMID 12445827.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.". J. Invest. Dermatol. 120 (4): 693-700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
• Kaneider NC, Lindner J, Feistritzer C, et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.". FASEB J. 18 (11): 1309-11. doi:10.1096/fj.03-1050fje. PMID 15208267.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Sanchez T, Thangada S, Wu MT, et al. (2005). "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.". Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4312-7. doi:10.1073/pnas.0409784102. PMID 15764699.
• Sanchez T, Skoura A, Wu MT, et al. (2007). "Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN.". Arterioscler. Thromb. Vasc. Biol. 27 (6): 1312-8. doi:10.1161/ATVBAHA.107.143735. PMID 17431187.

External links

• IUPHAR GPCR Database - Lysophospholipid receptors
• MeSH Lysophospholipid+receptors

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.