EDG1
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| Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | |||||||||||
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| Symbols | EDG1 ; ECGF1; CHEDG1; D1S3362; EDG-1; S1PR1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1071 | ||||||||||
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| Species | Human | Mouse | |||||||||
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EDG1 (endothelial differentiation gene 1) is a human gene which encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P1.
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.[1]
See also
References
Further reading
- Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441.
- Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 476–9. PMID 11915345.
- Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
- Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities". J. Biochem. 131 (6): 767–71. PMID 12038970.
- Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". J. Biol. Chem. 265 (16): 9308–13. PMID 2160972.
- Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. 271 (19): 11272–9. PMID 8626678.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- An S, Bleu T, Huang W; et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. PMID 9409733.
- Lee MJ, Van Brocklyn JR, Thangada S; et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–5. PMID 9488656.
- Lee MJ, Thangada S, Liu CH; et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist". J. Biol. Chem. 273 (34): 22105–12. PMID 9705355.
- Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. PMID 10383399.
- Windh RT, Lee MJ, Hla T; et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. PMID 10488065.
- Lee MJ, Thangada S, Claffey KP; et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. PMID 10555146.
- Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction". J. Biol. Chem. 275 (41): 32363–70. doi:10.1074/jbc.M003075200. PMID 10921915.
- Parrill AL, Wang D, Bautista DL; et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate". J. Biol. Chem. 275 (50): 39379–84. doi:10.1074/jbc.M007680200. PMID 10982820.
- Liu Y, Wada R, Yamashita T; et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation". J. Clin. Invest. 106 (8): 951–61. PMID 11032855.
- Murphy WJ, Eizirik E, Johnson WE; et al. (2001). "Molecular phylogenetics and the origins of placental mammals". Nature. 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.
- Hobson JP, Rosenfeldt HM, Barak LS; et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility". Science. 291 (5509): 1800–3. doi:10.1126/science.1057559. PMID 11230698.
- Lee MJ, Thangada S, Paik JH; et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis". Mol. Cell. 8 (3): 693–704. PMID 11583630.
External links
- IUPHAR GPCR Database - Lysophospholipid receptors
- Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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