EDG1

Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
Identifiers
Symbol(s)	EDG1; ECGF1; CHEDG1; D1S3362; EDG-1; S1PR1
External IDs	OMIM: 601974 MGI: 1096355 Homologene: 1071
Gene ontology Molecular Function: • lysosphingolipid and lysophosphatidic acid receptor activity • receptor activity Cellular Component: • plasma membrane • integral to plasma membrane Biological Process: • angiogenesis • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase inhibiting pathway • brain development • positive regulation of cell proliferation • regulation of cell adhesion
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1901	13609
Ensembl	ENSG00000170989	ENSMUSG00000045092
Uniprot	P21453	Q3UUK3
Refseq	NM_001400 (mRNA) NP_001391 (protein)	XM_986946 (mRNA) XP_992040 (protein)
Location	Chr 1: 101.48 - 101.48 Mb	Chr 3: 115.7 - 115.71 Mb
Pubmed search	[1]	[2]

EDG1 (endothelial differentiation gene 1) is a human gene which encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₁.

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.

See also

• Lysophospholipid receptor

Further reading

• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54-60. PMID 10818441.
• Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 476-9. PMID 11915345.
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496-502. PMID 11915348.
• Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.". J. Biochem. 131 (6): 767-71. PMID 12038970.
• Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.". J. Biol. Chem. 265 (16): 9308-13. PMID 2160972.
• Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.". J. Biol. Chem. 271 (19): 11272-9. PMID 8626678.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
• An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279-82. PMID 9409733.
• Lee MJ, Van Brocklyn JR, Thangada S, et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.". Science 279 (5356): 1552-5. PMID 9488656.
• Lee MJ, Thangada S, Liu CH, et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.". J. Biol. Chem. 273 (34): 22105-12. PMID 9705355.
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997-9002. PMID 10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351-8. PMID 10488065.
• Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell 99 (3): 301-12. PMID 10555146.
• Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.". J. Biol. Chem. 275 (41): 32363-70. doi:10.1074/jbc.M003075200. PMID 10921915.
• Parrill AL, Wang D, Bautista DL, et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.". J. Biol. Chem. 275 (50): 39379-84. doi:10.1074/jbc.M007680200. PMID 10982820.
• Liu Y, Wada R, Yamashita T, et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.". J. Clin. Invest. 106 (8): 951-61. PMID 11032855.
• Murphy WJ, Eizirik E, Johnson WE, et al. (2001). "Molecular phylogenetics and the origins of placental mammals.". Nature 409 (6820): 614-8. doi:10.1038/35054550. PMID 11214319.
• Hobson JP, Rosenfeldt HM, Barak LS, et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.". Science 291 (5509): 1800-3. doi:10.1126/science.1057559. PMID 11230698.
• Lee MJ, Thangada S, Paik JH, et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.". Mol. Cell 8 (3): 693-704. PMID 11583630.

External links

• IUPHAR GPCR Database - Lysophospholipid receptors
• MeSH Lysophospholipid+receptors

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub