Free fatty acid receptor 1

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Free fatty acid receptor 1
Identifiers
Symbols FFAR1 ; FFA1R; GPR40
External IDs Template:OMIM5 Template:MGI HomoloGene3876
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Free fatty acid receptor 1, also known as FFAR1, is a human gene.[1]


See also

References

  1. "Entrez Gene: FFAR1 free fatty acid receptor 1".

Further reading

  • Brown AJ, Jupe S, Briscoe CP (2005). "A family of fatty acid binding receptors". DNA Cell Biol. 24 (1): 54–61. doi:10.1089/dna.2005.24.54. PMID 15684720.
  • Sawzdargo M, George SR, Nguyen T; et al. (1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochem. Biophys. Res. Commun. 239 (2): 543–7. doi:10.1006/bbrc.1997.7513. PMID 9344866.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Briscoe CP, Tadayyon M, Andrews JL; et al. (2003). "The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids". J. Biol. Chem. 278 (13): 11303–11. doi:10.1074/jbc.M211495200. PMID 12496284.
  • Kotarsky K, Nilsson NE, Flodgren E; et al. (2003). "A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs". Biochem. Biophys. Res. Commun. 301 (2): 406–10. PMID 12565875.
  • Itoh Y, Kawamata Y, Harada M; et al. (2003). "Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40". Nature. 422 (6928): 173–6. doi:10.1038/nature01478. PMID 12629551.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Hardy S, St-Onge GG, Joly E; et al. (2005). "Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40". J. Biol. Chem. 280 (14): 13285–91. doi:10.1074/jbc.M410922200. PMID 15695516.
  • Ogawa T, Hirose H, Miyashita K; et al. (2005). "GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men". Metab. Clin. Exp. 54 (3): 296–9. doi:10.1016/j.metabol.2004.09.008. PMID 15736105.
  • Tomita T, Masuzaki H, Noguchi M; et al. (2006). "GPR40 gene expression in human pancreas and insulinoma". Biochem. Biophys. Res. Commun. 338 (4): 1788–90. doi:10.1016/j.bbrc.2005.10.161. PMID 16289108.
  • Tomita T, Masuzaki H, Iwakura H; et al. (2006). "Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion". Diabetologia. 49 (5): 962–8. doi:10.1007/s00125-006-0193-8. PMID 16525841.
  • Stoddart LA, Brown AJ, Milligan G (2007). "Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist". Mol. Pharmacol. 71 (4): 994–1005. doi:10.1124/mol.106.031534. PMID 17200419.
  • Bartoov-Shifman R, Ridner G, Bahar K; et al. (2007). "Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells". J. Biol. Chem. 282 (32): 23561–71. doi:10.1074/jbc.M702115200. PMID 17525159.
  • Sum CS, Tikhonova IG, Neumann S; et al. (2007). "Identification of residues important for agonist recognition and activation in GPR40". J. Biol. Chem. 282 (40): 29248–55. doi:10.1074/jbc.M705077200. PMID 17699519.