Drug allergy causes: Difference between revisions
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(/* Causes by Specific Allergic Reactions{{Cite journal | doi = 10.1016/j.jaci.2009.10.028 | issn = 1097-6825 | volume = 125 | issue = 2 Suppl 2 | pages = –126-137 | last = Khan | first = David A. | coauthors = Roland Solensky | title = Drug allergy |...) |
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__NOTOC__ | __NOTOC__ | ||
{{Drug allergy}} | {{Drug allergy}} | ||
{{CMG}}; {{AE}} {{CP}} | {{CMG}}; {{AE}} {{CP}}, {{JM}} | ||
==Overview== | ==Overview== | ||
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==Causes== | ==Causes== | ||
===Common Causes=== | ===Common Causes=== | ||
When a medication causes an allergic reaction, it is called an [[allergen]]. The following is a short list of the most common drug allergens | When a medication causes an allergic reaction, it is called an [[allergen]]. The following is a short list of the most common drug allergens | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Drug Effect''' | | '''Drug Effect''' | ||
|bgcolor="Beige"| [[Abciximab]], [[Acetazolamide]], [[Allopurinol]], [[ | |bgcolor="Beige"| [[Abatacept]], [[Abciximab]], [[Acebutolol]], [[Acetazolamide]], [[Acetylcysteine]], [[Acyclovir]], [[Adalimumab]], [[Adapalene]], [[Adenosine]], [[Albuterol]], [[Alendronate]], [[Aliskiren]], [[Allopurinol]], [[Alteplase]], [[Amifostine]], [[Amiloride]], [[Aminocaproic acid]], [[Amiodarone]], [[Amlodipine]], [[Amlodipine besylate and Valsartan]], [[Anastrozole]], [[Antihemophilic factor]], [[Anti-inhibitor coagulant complex]], [[Antithrombin III]], [[Argatroban]], [[Aripiprazole]], [[Armodafinil]], [[Atazanavir]], [[Atenolol]], [[Atomoxetine]], [[Atorvastatin calcium]], [[Barbiturates]], [[Benazepril]], [[Bendamustine]], [[Benoxaprofen]], [[Betaxolol]], [[Bevacizumab]], [[Bisoprolol]], [[Botulinum toxin]], [[Brentuximab vedotin]], [[Brimonidine]], [[Brinzolamide]], [[Budesonide And Formoterol Fumarate Dihydrate]], [[Bumetanide]], [[Buprenorphine Hydrochloride, Naloxone Hydrochloride]], [[Cabergoline]], [[Captopril]], [[Carbamazepine]], [[Carbidopa and Levodopa]], [[Carteolol]], [[Carvedilol]], [[Cefdinir]], [[Celecoxib]], [[Cephalosporins]], [[Cetuximab]], [[Chlorambucil]], [[Chlormezanone]], [[Chlorothiazide]], [[Chlorthalidone]], [[Cholestyramine]], [[Ciclosporin]], [[Cilostazol]], [[Ciprofloxacin and Dexamethasone]], [[Citalopram Hydrobromide]], [[Clindamycin]], [[Clonidine]], [[Clopidogrel]], [[Coagulation factor VIIa]], [[Codeine]], [[Colestipol]], [[Conivaptan]], [[Cyclobenzaprine]], [[Cyclophosphamide]], [[Dabigatran]], [[Dalteparin]], [[Danazol]], [[Daptomycin]], [[Darbepoetin Alfa]], [[Darifenacin]], [[Dasatinib]], [[Denosumab]], [[Desirudin]], [[Desvenlafaxine]], [[Dexamethasone]], [[Dexlansoprazole]], [[Dexmethylphenidate]], [[Diazoxide]], [[Diclofenac]], [[Diclofenamide]], [[Dofetilide]], [[Digoxin]], [[Digoxin immune fab]], [[Diltiazem]], [[Donepezil]], [[Dipyridamole]], [[Disopyramide]], [[Dobutamine]], [[Dorzolamide]], [[Doxycycline Hyclate]], [[Dronedarone]], [[Duloxetine]], [[Dutasteride]], [[Dutasteride and Tamsulosin hydrochloride]], [[Efavirenz, Emtricitabine, and Tenofovir disoproxil fumarate]], [[Ethynodiol diacetate and ethinyl estradiol]], [[Enalapril maleate]], [[Enoxaparin]], [[Epoetin alfa]], [[Eprosartan]], [[Eptifibatide]], [[Erlotinib]], [[Erythropoietin]], [[Esmolol]], [[Esomeprazole]], [[Eszopiclone]], [[Etanercept]], [[Etonogestrel and Ethinyl Estradiol Vaginal Ring]], [[Ethacrynic acid]], [[Ethambutol]], [[Ethotoin]], [[Etodolac]], [[Etravirine]], [[Everolimus]], [[Exenatide]], [[Ezetimibe]], [[Ezetimibe And Simvastatin]], [[Factor IX complex]], [[Felodipine]], [[Fenofibrate]], [[Fenoldopam]], [[Filgrastim]], [[Flecainide]], [[Fluconazole]], [[Fluphenazine]], [[Fluticasone]], [[Fluticasone and Salmeterol]], [[Fluvastatin]], [[Fondaparinux]], [[Fosamprenavir]], [[Fosinopril]], [[Glimepiride]], [[Glyburide and Metformin]], [[Gold]], [[HPV Vaccine]], [[Hydrocodone bitartrate and Homatropine methylbromide]], [[Ibandronic acid]], [[Ibritumomab tiuxetan]], [[Ibuprofen]], [[Imiquimod]], [[Interferon beta-1b]], [[Ipilimumab]], [[Insulin]], [[Insulin glulisine]], [[Interferon beta-1a]], [[Ipratropium Bromide And Albuterol]], [[Irbesartan]], [[Isoniazid]], [[Isotretinoin]], [[Ketorolac tromethamine]] [[Lamotrigine]], [[Leflunomide]], [[Lenalidomide]], [[levetiracetam]], [[Levonorgestrel and Ethinyl estradiol]], [[Linagliptin]], [[Linagliptin and Metformin hydrochloride]], [[Lisinopril and Hydrochlorothiazide]], [[Losartan and Hydrochlorothiazide]], [[Medroxyprogesterone]], [[Mefenamic acid]], [[Meloxicam]], [[Mesalamine]], [[Metformin]], [[Methimazole]], [[Methotrexate]], [[Methyldopa]], [[Methylphenidate]], [[Metronidazole]], [[Mirabegron]], [[Moxifloxacin]], [[Mupirocin]], [[Mycophenolate]], [[Nafarelin]], [[Naproxen sodium]], [[Nebivolol]], [[Nevirapine]], [[Nitrofurantoin]], [[Norgestimate and Ethinyl estradiol]], [[Norgestrel and Ethinyl estradiol]], [[NSAIDs]], [[Nystatin]], [[Ofloxacin]], [[Oxycodone]], [[Oxytocin]], [[Pantoprazole]], [[Paroxetine]], [[Pemetrexed]], [[Penicillamine]], [[Pentosan polysulfate]], [[Phenacetin]], [[Phenobarbitol]], [[Phenylbutazone]], [[Piroxicam]], [[Prochlorperazine]], [[Progesterone]], [[Saxagliptin hydrochloride and Metformin hydrochloride]], [[Phenytoin]], [[Pioglitazone]], [[Potassium chloride]], [[Primidone]], [[Procainamide]], [[Quinidine]], [[Rifabutin]], [[Risedronate]], [[Rosiglitazone]], [[Rosuvastatin]], [[Sorafenib]], [[Streptomycin]], [[Sulfacetamide sodium And Prednisolone acetate]], [[Sulfasalazine]], [[Sulfonamide]], [[Sulfonylurea]], [[Sumatriptan]], [[Suramin]], [[Tacrolimus]], [[Tamoxifen]], [[Terbinafine]], [[Tetracycline]], [[Thiabendazole]], [[Thioacetazone]], [[Tolterodine]], [[Tretinoin]], [[Triamcinolone]], [[Valsartan]], [[Vancomycin]], [[Vandetanib]], [[Varenicline]], [[Zaleplon]], [[Zanamivir]], [[Zidovudine]], [[Zolpidem]], [[Zonisamide]] | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Ear Nose Throat''' | | '''Ear Nose Throat''' | ||
| Line 139: | Line 135: | ||
{{col-break|width=33%}} | {{col-break|width=33%}} | ||
* [[Abatacept]] | |||
* [[Abciximab]] | |||
* [[Acebutolol]] | |||
* [[Acetylcysteine]] | |||
* [[Acyclovir]] | |||
* [[Acetazolamide]] | * [[Acetazolamide]] | ||
* [[Adalimumab]] | |||
* [[Adapalene]] | |||
* [[Adenosine]] | |||
* [[Albuterol]] | |||
* [[Alendronate]] | |||
* [[Aliskiren]] | |||
* [[Allopurinol]] | * [[Allopurinol]] | ||
* [[Alteplase]], | |||
* [[Amifostine]] | * [[Amifostine]] | ||
* [[Amiloride]] | |||
* [[Aminocaproic acid]] | |||
* [[Amiodarone]] | |||
* [[Amlodipine]] | |||
* [[Amlodipine besylate and Valsartan]] | |||
* [[Anastrozole]] | |||
* [[Antihemophilic factor]] | |||
* [[Anti-inhibitor coagulant complex]] | |||
* [[Antithrombin III]] | |||
* [[Argatroban]] | |||
* [[Aripiprazole]] | |||
* [[Armodafinil]] | |||
* [[Atazanavir]] | |||
* [[Atenolol]] | |||
* [[Atomoxetine]] | |||
* [[Atorvastatin calcium]] | |||
* [[Barbiturates]] | * [[Barbiturates]] | ||
* [[Benoxaprofen]] | * [[Benoxaprofen]] | ||
* [[Benazepril]] | |||
* [[Bendamustine]] | |||
* [[Betaxolol]] | |||
* [[Bevacizumab]] | |||
* [[Bisoprolol]] | |||
* [[Bivalirudin]] | |||
* [[Bortezomib]] | |||
* [[Brentuximab vedotin]] | * [[Brentuximab vedotin]] | ||
* [[Brimonidine]] | |||
* [[Brinzolamide]] | |||
* [[Budesonide And Formoterol Fumarate Dihydrate]] | |||
* [[Bumetanide]] | |||
* [[Buprenorphine Hydrochloride, Naloxone Hydrochloride]] | |||
* [[Cabergoline]] | |||
* [[Candesartan]] | |||
* [[Capecitabine]] | |||
* [[Captopril]] | |||
* [[Carbamazepine]] | * [[Carbamazepine]] | ||
* [[Carbidopa and Levodopa]] | |||
* [[Carteolol]] | |||
* [[Carvedilol]] | |||
* [[Cefdinir]] | |||
* [[Celecoxib]] | |||
* [[Cephalosporins]] | * [[Cephalosporins]] | ||
* [[Cetuximab]] | |||
* [[Chlorambucil]] | * [[Chlorambucil]] | ||
* [[Chlormezanone]] | * [[Chlormezanone]] | ||
* [[Chlorothiazide]] | |||
* [[Chlorthalidone]] | |||
* [[Cholestyramine]] | |||
* [[Ciclosporin]] | |||
* [[Cilostazol]] | |||
* [[Ciprofloxacin and Dexamethasone]] | |||
* [[Citalopram Hydrobromide]] | |||
* [[Clindamycin]] | * [[Clindamycin]] | ||
* [[Clonidine]] | |||
* [[Clopidogrel]] | |||
* [[Coagulation factor VIIa]] | |||
* [[Codeine]] | * [[Codeine]] | ||
* [[Colestipol]] | |||
* [[Conivaptan]] | |||
* [[Crotamiton]] | |||
* [[Cyclobenzaprine]] | |||
* [[Cyclophosphamide]] | |||
* [[Dabigatran]] | |||
* [[Dalteparin]] | |||
* [[Danazol]] | |||
* [[Daptomycin]] | |||
* [[Darbepoetin Alfa]] | |||
* [[Darifenacin]] | |||
* [[Darunavir]] | |||
* [[Dasatinib]] | |||
* [[Denosumab]] | |||
* [[Desirudin]] | |||
* [[Desvenlafaxine]] | |||
* [[Dexamethasone]] | |||
* [[Dexlansoprazole]] | |||
* [[Dexmethylphenidate]] | |||
* [[Diazoxide]] | |||
* [[Diclofenac]] | * [[Diclofenac]] | ||
* [[Diclofenamide]] | |||
* [[Digoxin]] | |||
* [[Digoxin immune fab]] | |||
* [[Diltiazem]] | * [[Diltiazem]] | ||
* [[Dipyridamole]] | |||
* [[Disopyramide]] | |||
* [[Dobutamine]] | |||
* [[Dofetilide]] | |||
* [[Donepezil]] | |||
* [[Dorzolamide]] | |||
* [[Doxazosin]] | |||
* [[Doxycycline Hyclate]] | |||
* [[Dronedarone]] | |||
* [[Metronidazole]] | |||
* [[Duloxetine]] | |||
* [[Dutasteride]] | |||
* [[Dutasteride and Tamsulosin hydrochloride]] | |||
* [[Efavirenz, Emtricitabine, and Tenofovir disoproxil fumarate]] | |||
* [[Enalapril maleate]] | |||
* [[Enoxaparin]] | |||
* [[Epoetin alfa]] | |||
* [[Eprosartan]] | |||
* [[Eptifibatide]] | |||
* [[Erlotinib]] | * [[Erlotinib]] | ||
* [[Erythropoietin]] | |||
* [[Esmolol]] | |||
* [[Esomeprazole]] | |||
* [[Eszopiclone]] | |||
* [[Etanercept]] | |||
* [[Ethacrynic acid]] | |||
* [[Ethambutol]] | |||
* [[Ethotoin]] | * [[Ethotoin]] | ||
* [[Etravirine]] | * [[Etonogestrel and Ethinyl Estradiol Vaginal Ring]] | ||
* [[Etravirine]] | |||
* [[Etodolac]] | |||
* [[Everolimus]] | |||
* [[Exenatide]] | |||
* [[Ezetimibe And Simvastatin]] | |||
{{col-break|width=33%}} | {{col-break|width=33%}} | ||
* [[Factor IX complex]] | |||
* [[Felodipine]] | |||
* [[Fenofibrate]] | |||
* [[Fenoldopam]] | |||
* [[Filgrastim]] | |||
* [[Flecainide]] | |||
* [[Fluconazole]] | |||
* [[Fluorometholone]] | |||
* [[Fluoxetine]] | |||
* [[Fluphenazine]] | |||
* [[Fluticasone]] | |||
* [[Fluticasone and Salmeterol]] | |||
* [[Fluvastatin]] | |||
* [[Fondaparinux]] | |||
* [[Fosamprenavir]] | * [[Fosamprenavir]] | ||
* [[Fosinopril]] | |||
* [[Glimepiride]] | |||
* [[Glyburide]] | |||
* [[Glipizide]] | |||
* [[Glucagon]] | |||
* [[Glyburide and Metformin]] | |||
* [[Gold]] | * [[Gold]] | ||
* [[HPV Vaccine]] | |||
* [[Hydrocodone bitartrate and Homatropine methylbromide]] | |||
* [[Ibandronic acid]] | |||
* [[Ibritumomab tiuxetan]] | * [[Ibritumomab tiuxetan]] | ||
* [[Ibuprofen]] | |||
* [[Imiquimod]] | |||
* [[Ipilimumab]] | * [[Ipilimumab]] | ||
* [[Insulin]] | * [[Ipratropium Bromide And Albuterol]] | ||
* [[Insulin]] | |||
* [[Insulin glulisine]] | |||
* [[Interferon beta-1a]] | |||
* [[Interferon beta-1b]] | |||
* [[Irbesartan]] | |||
* [[Isoniazid]] | * [[Isoniazid]] | ||
* [[Isotretinoin]] | |||
* [[Ketorolac tromethamine]] | |||
* [[Lamotrigine]] | * [[Lamotrigine]] | ||
* [[Leflunomide]] | * [[Leflunomide]] | ||
* [[Lenalidomide]] | * [[Lenalidomide]] | ||
* [[Levetiracetam]] | |||
* [[Levonorgestrel and Ethinyl estradiol]] | |||
* [[Linagliptin]] | |||
* [[Linagliptin and Metformin hydrochloride]] | |||
* [[Lisinopril and Hydrochlorothiazide]] | |||
* [[Losartan and Hydrochlorothiazide]] | |||
* [[Medroxyprogesterone]] | |||
* [[Mefenamic acid]] | |||
* [[Meloxicam]] | |||
* [[Mesalamine]] | |||
* [[Metformin]] | |||
* [[Methotrexate]] | |||
* [[Methyldopa]] | * [[Methyldopa]] | ||
* [[Methylphenidate]] | * [[Methylphenidate]] | ||
* [[Mirabegron]] | |||
* [[Moxifloxacin]] | |||
* [[Mupirocin]] | |||
* [[Mycophenolate]] | |||
* [[Nafarelin]] | |||
* [[Naproxen sodium]] | |||
* [[Nebivolol]] | |||
* [[Nevirapine]] | * [[Nevirapine]] | ||
* [[Nitrofurantoin]] | |||
* [[Norgestimate and Ethinyl estradiol]] | |||
* [[Norgestrel and Ethinyl estradiol]] | |||
* [[NSAIDs]] | * [[NSAIDs]] | ||
* [[Nystatin]] | |||
* [[Ofloxacin]] | |||
* [[Olmesartan]] | |||
* [[Oxycodone]] | |||
* [[Oxytocin]] | |||
* [[Pantoprazole]] | |||
* [[Paroxetine]] | |||
* [[Pemetrexed]] | |||
* [[Penicillamine]] | * [[Penicillamine]] | ||
* [[Pentosan polysulfate]] | |||
* [[Phenacetin]] | * [[Phenacetin]] | ||
* [[Phenobarbitol]] | * [[Phenobarbitol]] | ||
| Line 179: | Line 352: | ||
{{col-break|width=33%}} | {{col-break|width=33%}} | ||
* [[Phenytoin]] | * [[Phenytoin]] | ||
* [[Pimecrolimus]] | |||
* [[Pioglitazone]] | |||
* [[Piroxicam]] | |||
* [[Potassium chloride]] | |||
* [[Primidone]] | * [[Primidone]] | ||
* [[Procainamide]] | * [[Procainamide]] | ||
* [[Quinidine]] | * [[Prochlorperazine]] | ||
* [[Progesterone]] | |||
* [[Quinidine]] | |||
* [[Rifabutin]] | |||
* [[Risedronate]] | |||
* [[Rosiglitazone]] | |||
* [[Rosuvastatin]] | |||
* [[Saxagliptin hydrochloride and Metformin hydrochloride]] | |||
* [[Sorafenib]] | * [[Sorafenib]] | ||
* [[Streptomycin]] | * [[Streptomycin]] | ||
* [[Sulfacetamide sodium And Prednisolone acetate]] | |||
* [[Sulfasalazine]] | * [[Sulfasalazine]] | ||
* [[Sulfonamide]] | * [[Sulfonamide]] | ||
* [[Sulfonylurea]] | * [[Sulfonylurea]] | ||
* [[Sumatriptan]] | |||
* [[Suramin]] | * [[Suramin]] | ||
* [[Tacrolimus]] | |||
* [[Tamoxifen]] | |||
* [[Terbinafine]] | * [[Terbinafine]] | ||
* [[Tetracycline]] | * [[Tetracycline]] | ||
* [[Thiabendazole]] | * [[Thiabendazole]] | ||
* [[Thioacetazone]] | * [[Thioacetazone]] | ||
* [[Tolterodine]] | |||
* [[Tretinoin]] | |||
* [[Triamcinolone]] | |||
* [[Valsartan]] | |||
* [[Vancomycin]] | * [[Vancomycin]] | ||
* [[Vandetanib]] | * [[Vandetanib]] | ||
* [[Venlafaxine]] | |||
* [[Varenicline]] | |||
* [[Zaleplon]] | |||
* [[Zanamivir]] | |||
* [[Zidovudine]] | |||
* [[Zolpidem]] | |||
* [[Zonisamide]] | * [[Zonisamide]] | ||
{{col-end}} | {{col-end}} | ||
===Causes by Specific Allergic Reactions<ref>{{Cite journal | doi = 10.1016/j.jaci.2009.10.028 | issn = 1097-6825 | volume = 125 | issue = 2 Suppl 2 | pages = –126-137 | last = Khan | first = David A. | coauthors = Roland Solensky | title = Drug allergy | journal = The Journal of Allergy and Clinical Immunology | date = 2010-02 | pmid = 20176256 }}</ref><ref>{{cite book | last = Lee | first = Anne | title = Adverse drug reactions | publisher = Pharmaceutical Press | location = London Chicago | year = 2006 | isbn = 0853696012 }}</ref>=== | |||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 80%;" align=center | |||
! style="background: #4479BA; padding: 5px 5px; width: 20%;" | {{fontcolor|#FFFFFF|Cutaneous reactions}} | |||
! style="background: #4479BA; padding: 5px 5px; width: 30%;" | {{fontcolor|#FFFFFF|Clinical features}} | |||
! style="background: #4479BA; padding: 5px 5px; width: 50%;" | {{fontcolor|#FFFFFF|Implicated medications}} | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Exanthems | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Delayed-type hypersensitivity <BR> ▸ Evolve over days after drug initiation <BR> ▸ Diffuse macules and papules | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Allopurinol]], [[Amlodipine]], [[Amphotericin]], [[Barbiturates]], [[Captopril]], [[carbamazepine]], [[cephalosporins]], [[chloramphenicol]], [[Digoxin]], [[Erythromycin]], [[Furosemide]], [[gentamicin]], [[Glipizide]], [[gold salts]], [[Lithium]], [[Nalidixic acid]], [[Nitrofurantoin]], [[Penicillins]], [[Phenothiazines]], [[Phenylbutazone]], [[Phenytoin]], [[Sulfonamides]], [[Thiazides]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Urticaria/ angioedema | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Often IgE mediated <BR> ▸ Onset within minutes of drug initiation | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Abatacept]], [[ACE inhibitors]], [[Acetylcysteine]], [[Acyclovir]], [[Adalimumab]], [[Albuterol]], [[Alendronate]], [[Aliskiren]], [[Alteplase]], [[Aminosalicylic acid]], [[Amlodipine]], [[Amlodipine and Benazepril]], [[Anastrozole]], [[Anti-inhibitor coagulant complex]], [[Anticonvulsants]], [[Antihemophilic factor]], [[Antithrombin III]], [[Aripiprazole]], [[Armodafinil]], [[Aspirin]], [[Atomoxetine]], [[Atropine]], [[Beclometasone dipropionate]], [[Benazepril]], [[Budesonide And Formoterol Fumarate Dihydrate]], [[Butabarbital]], [[Captopril]], [[Carbidopa and Levodopa]], [[Carvedilol]], [[Celecoxib]], [[cephalosporins]], [[Cetuximab]], [[Cholestyramine]], [[Ciclosporin]], [[Cisplatin]], [[Clomifene]], [[Clonidine]], [[Clopidogrel]], [[Colestipol]], [[Cyclobenzaprine]], [[Darbepoetin Alfa]], [[Darifenacin]], [[Darunavir]], [[Dasatinib]], [[Deferasirox]], [[Denosumab]], [[desvenlafaxine]], [[Dexamethasone]], [[Dexlansoprazole]], [[Dexmethylphenidate]], [[Dextran]], [[Diflunisal]], [[Digoxin immune fab]], [[Dofetilide]], [[Donepezil]], [[Dutasteride]], [[Dutasteride and Tamsulosin hydrochloride]], [[Enalapril maleate]], [[Enoxaparin]], [[Epoetin alfa]], [[Erythropoietin]], [[Esomeprazole]], [[Eszopiclone]], [[Everolimus]], [[Exenatide]], [[Ezetimibe]], [[Factor IX complex]], [[Febuxostat]], [[Felodipine]], [[Fesoterodine]], [[Filgrastim]], [[Fluoxetine]], [[Fluphenazine]], [[Fluticasone]], [[Fosinopril]], [[Frovatriptan]], [[Gemfibrozil]], [[Gentamicin]], [[Glimepiride]], [[Glipizide]], [[Glyburide]], [[Heparin]], [[Hydralazine]], [[Hydroxychloroquine]], [[Hyoscyamine]], [[Ibuprofen]], [[Indomethacin]], [[Interferon beta-1a]], [[Ipratropium bromide]], [[Ipratropium Bromide And Albuterol]], [[Irbesartan]], [[Isotretinoin]], [[Isradipine]], [[Lamotrigine]], [[Levalbuterol]], [[Levonorgestrel and Ethinyl estradiol]], [[Levothyroxine]], [[Linagliptin]], [[Linagliptin and Metformin hydrochloride]], [[Liraglutide]], [[Lisinopril]], [[Lisinopril and Hydrochlorothiazide]], [[Loperamide]], [[Losartan and Hydrochlorothiazide]], [[Medroxyprogesterone]], [[Minocycline hydrochloride]], [[Moxifloxacin ophthalmic]], [[Mupirocin]], [[Losartan]], [[Meloxicam]], [[Metaxalone]], [[Methimazole]], [[Methocarbamol]], [[Methylphenidate]], [[Metoclopramide]], [[Metolazone]], [[Mirabegron]], [[Modafinil]], [[Moexipril hydrochloride]], [[Monoclonal antibodies]], [[Moxifloxacin]], [[Nabumetone]], [[Nafarelin]], [[Naltrexone]], [[Naproxen and esomeprazole magnesium]], [[Nisoldipine]], [[Nitrofurantoin]], [[Norgestimate and Ethinyl estradiol]], [[NSAIDs]], [[Ofloxacin]], [[Olodaterol]], [[Olmesartan]], [[Omalizumab]], [[Opioids]], [[Orphenadrine]], [[Oxcarbazepine]], [[Oxycodone]], [[Pantoprazole]], [[Pegfilgrastim]], [[Penicillins]], [[Pentamidine Isethionate]], [[Pentoxifylline]], [[Perindopril]], [[Phentermine]], [[Pramipexole]], [[Prochlorperazine]], [[Promethazine]], [[Rifaximin]], [[Saxagliptin]], [[Saxagliptin hydrochloride and Metformin hydrochloride]], [[Sertraline]], [[Pitavastatin]], [[Procainamide]], [[Rizatriptan]], [[Quinidine sulfate]], [[Quinine]], [[Ramipril]], [[Ranolazine]], [[Raxibacumab]], [[Repaglinide]], [[Risedronate]], [[Rosuvastatin]], [[Sitagliptin]], [[Sulfonamides]], [[Sumatriptan]], [[Tenofovir]], [[Tetracyclines]], [[Thalidomide]], [[Thiouracil]], [[Ticlopidine]], [[Tizanidine]], [[Tocilizumab]], [[Tolterodine]], [[Tubocurarine]], [[Ustekinumab]], [[Valacyclovir]], [[Valsartan]], [[Vancomycin]], [[Vardenafil]], [[Varenicline]], [[Velaglucerase alfa]], [[Zaleplon]], [[Zolmitriptan]], [[Zolpidem]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Fixed drug eruption | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Hyperpigmented plaques that recur at same skin or mucosal site | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[ACE inhibitors]], [[adalimumab]], [[allopurinol]], [[amlodipine]], [[aspirin]], [[barbiturates]], [[benzodiazepines]], [[carbamazepine]], [[cephalosporins]], [[clindamycin]], [[co-trimoxazole]], [[dextromethorphan]], [[diltiazem]], [[fluconazole]], [[lamotrigine]], [[lansoprazole]], [[metronidazole]], [[NSAIDs]], [[paclitaxel]], [[paracetamol]], [[penicillin]], [[phenolphthalein]], [[omeprazole]], [[quinine]], [[salicylates]], [[sulfonamides]], [[terbinafine]], [[tetracyclines]], [[trimethoprim]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pustules | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Acute generalized eczematous pustulosis or acneiform rash | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[antibiotics]], [[calcium-channel blockers]], [[corticosteroids]], [[sirolimus]],[[Fluticasone]],[[Erlotinib]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Bullous | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Flaccid or tense blisters | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Argatroban]], [[Bendamustine]], [[Captopril]], [[Carbidopa and Levodopa]], [[Dasatinib]], [[Erlotinib]], [[Penicillamine]], [[Furosemide]], [[Risedronate]], [[Vancomycin]],[[Abciximab]]，[[Warfarin]], [[Topiramate]]，[[Linezolid]],[[Mirtazapine]]，[[Dapsone]], [[Allopurinol]],[[Captopril ]]，[[Captopril and Hydrochlorothiazide]],[[Clopidogrel]],[[Erlotinib]],[[Fosinopril]], [[Ibuprofen]], [[Imatinib]],[[Indapamide]],[[Risedronate]],[[Zolpidem]],[[Dasatinib]],[[Minoxidil]],[[Labetalol]],[[Phenytoin]],[[Dalteparin]],[[Bendamustine]],[[Tinzaparin]],[[Tamoxifen]],[[ clarithromycin]],[[Atorvastatin calcium]],[[Caduet]],[[Ticarcillin/Clavulanate]],[[Terbinafine]],[[Quinine]],[[Nevirapine]],[[Topiramate]],[[Perindopril]],[[Moexipril/Hydrochlorothiazide]], [[Naproxen sodium]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Cutaneous lupus erythematosus | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Erythematous/scaly plaques in photodistribution | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Hydrochlorothiazide]], [[calcium-channel blockers]], [[ACEIs]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Stevens-Johnson syndrome (SJS) | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Purpuric macules on face and trunk with <10% epidermal detachment, fever, stomatitis, ocular involvement | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Antibiotics]], [[Acetazolamide]], [[Acyclovir]], [[Alendronate]], [[Armodafinil]], [[Atazanavir]], [[Barbiturates]], [[Bendamustine]], [[Beta-lactam|Β-lactam antibiotics]], [[Brinzolamide]], [[Carbamazepine]], [[Carvedilol]], [[Celecoxib]], [[Chlorpropamide]], [[Co-trimoxazole]], [[Darunavir]], [[Delavirdine]], [[Deferasirox]], [[Diflunisal]], [[Dorzolamide]], [[Duloxetine]], [[efavirenz, emtricitabine, and tenofovir disoproxil fumarate]], [[Erlotinib]], [[Escitalopram]], [[Etodolac]], [[Fenofibrate]], [[Glimepiride]], [[Gold]], [[H2 Antagonist]]s, [[Histamine]], [[Hydroxychloroquine]], [[Indapamide]], [[Indomethacin]], [[Isotretinoin]], [[Ketorolac tromethamine]], [[Lamotrigine]], [[Leflunomide]], [[levetiracetam]],[[Lisinopril and Hydrochlorothiazide]], [[Macrolides]], [[Mefenamic acid]], [[Meloxicam]], [[Metolazone]], [[Mefloquine]], [[Methotrexate]], [[Mexiletine]], [[Minocycline hydrochloride]], [[Minoxidil]], [[Mirabegron]], [[Modafinil]], [[Naproxen and esomeprazole magnesium]], [[Piroxicam]], [[Moxifloxacin]], [[Nitrofurantoin]], [[NSAIDS]], [[Ofloxacin]], [[Olmesartan medoxomil-Hydrochlorothiazide]], [[Oxcarbazepine]], [[Phenothiazines]], [[Phenytoin]], [[Rifampicin]], [[Rivaroxaban]], [[Simvastatin]], [[Sitagliptin]], [[Spironolactone]], [[sulfacetamide sodium and prednisolone acetate]], [[Sulfonamides]], [[Tadalafil]], [[Tetracyclines]], [[Thalidomide]], [[Thiazides]], [[Ticlopidine]], [[Varenicline]], [[Zidovudine]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Toxic epidermal necrolysis (TEN) | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Similar to SJS but >30% epidermal detachment | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Acetazolamide]], [[Acyclovir]], [[Alendronate]], [[Allopurinol]], [[Armodafinil]], [[Atazanavir]], [[Barbiturates]], [[Bendamustine]], [[Brinzolamide]], [[Carbamazepine]], [[Celecoxib]], [[Delavirdine]], [[Diflunisal]], [[Dorzolamide]], [[Erlotinib]], [[Escitalopram]], [[Etodolac]], [[Finasteride]], [[Gold]], [[Griseofulvin]], [[Indapamide]], [[Indomethacin]], [[Isotretinoin]], [[Ketorolac tromethamine]], [[Lamotrigine]], [[Leflunomide]], [[levetiracetam]], [[Lisinopril and Hydrochlorothiazide]], [[Mefenamic acid]], [[Meloxicam]], [[Methotrexate]], [[Metolazone]], [[Minocycline hydrochloride]], [[Modafinil]], [[Moxifloxacin]], [[Naproxen and esomeprazole magnesium]], [[Nitrofurantoin]], [[NSAIDs]], [[Ofloxacin]], [[Olmesartan Medoxomil-Hydrochlorothiazide]], [[Oxcarbazepine]], [[Penicillins]], [[Phenytoin]], [[Piroxicam]], [[Salicylates]], [[Sitagliptin]], [[Spironolactone]], [[Sulfacetamide sodium And Prednisolone acetate]], [[sulfonamides]], [[tetracyclines]], [[Thalidomide]] | |||
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{| style="border: 0px; font-size: 90%; margin: 3px; width: 80%;" align=center | |||
! style="background: #4479BA; padding: 5px 5px; width: 20%;" | {{fontcolor|#FFFFFF|Organ-specific reactions}} | |||
! style="background: #4479BA; padding: 5px 5px; width: 30%;" | {{fontcolor|#FFFFFF|Clinical features}} | |||
! style="background: #4479BA; padding: 5px 5px; width: 50%;" | {{fontcolor|#FFFFFF|Implicated medications}} | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Pulmonary | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Pulmonary fibrosis, hypersensitivity pneumonitis | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Nitrofurantoin]], [[bleomycin]], [[Cabergoline]], [[Cetuximab]], [[Desvenlafaxine]], [[Dronedarone]], [[Erlotinib]], [[Hydrochlorothiazide]], [[Methyclothiazide]], [[Methotrexate]], [[Amiodarone]], [[Moxifloxacin]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hepatic | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Hepatitis, cholestasis | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Acetazolamide]], [[Aminosalicylic acid|Para-aminosalicylic acid]], [[Brinzolamide]], [[Dorzolamide]], [[Ofloxacin]], [[Sulfacetamide sodium And Prednisolone acetate]], [[sulfonamides]], [[phenothiazines]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Renal | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Interstitial nephritis, membranous glomerulonephritis | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top |[[Ofloxacin]], [[Penicillin]], [[sulfonamides]], [[gold]], [[penicillamine]], [[allopurinol]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Hematologic | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Hemolytic anemia, thrombocytopenia, granulocytopenia | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | | |||
▸ Hemolytic anemia — [[5-Azacytidine]], [[Acetophenazine]], [[Aclarubicin]], [[Actinomycin D]], [[Albendazole]], [[Alemtuzumab]], [[Aminopyrine]], [[Amitriptyline]], [[Amodiaquine]], [[Anakinra]], [[Antipyrine]], [[Azathioprine]], [[Bevacizumab]], [[Bortezomib]], [[Captopril]], [[Carbimazole]], [[Caspofungin]], [[Chloramphenicol]], [[Chlorpromazine]], [[Ciclosporin]], [[Cidofovir]], [[Cilazapril]], [[Clofarabine]], [[Clozapine]], [[Deferiprone]], [[Desipramine]], [[Docetaxel]], [[Dothiepin]], [[Doxorubicin]], [[Eflornithine]], [[Ethosuximide]], [[Erlotinib]], [[Ethotoin]], [[Flucytosine]], [[Fludarabine]], [[Fondaparinux]], [[Ganciclovir]], [[Gemcitabine]], [[Glimepiride]], [[Glyburide]], [[Glyburide and Metformin]], [[Gold salts]], [[Hydroxycarbamide]], [[Hypersplenism]], [[Ibritumomab tiuxetan]], [[Idarubicin]], [[Imatinib mesylate]], [[Interferon alpha]], [[Interferon beta]], [[Irinotecan]], [[Isoniazid]], [[Levomepromazine]], [[Lisinopril and Hydrochlorothiazide]], [[Mercaptopurine]], [[Methimazole]], [[Mirtazapine]], [[Mitoxantrone]], [[Nortriptyline]], [[Ofloxacin]], [[Paclitaxel]], [[Penicillamine]], [[Pentamidine]], [[Pentostatin]], [[Perazine]], [[Phenylbutazone]], [[Phenytoin]], [[Pipothiazine]], [[Procainamide]], [[Propylthiouracil]], [[Pyrimethamine]], [[Quinidine]], [[Remoxipride]], [[Riluzole]], [[Stiripentol]], [[Sulfasalazine]], [[Sulphonamides]], [[Ticlopidine]], [[Topotecan]], [[Trastuzumab]], [[Trimetrexate]], [[Valganciclovir]], [[Zidovudine]], [[Zileuton]] | |||
▸ Thrombocytopenia — [[Abciximab]], [[Aldesleukin]], [[Amobarbital]], [[Amrinone]], [[Armodafinil]], [[Capreomycin]], [[Carboplatin]], [[Cefotaxime]], [[Cefotetan]], [[Cefoxitin]], [[Ceftizoxime]], [[Chloramphenicol]], [[Chlorpropamide]], [[Ciclosporin]], [[Cinoxacin]], [[Claforan]], [[Diabinese]], [[Digoxin]], [[Disopyramide]], [[Enoxaparin]], [[Eptifibatide]], [[Erlotinib]], [[Estrogens]], [[Ethanol]], [[Exna]], [[Fondaparinux]], [[Glyburide]], [[Heparin]], [[Lisinopril and Hydrochlorothiazide]], [[Ofloxacin]], [[Paraplatin]], [[Phenylbutazone]], [[Procainamide]], [[Proleukin]], [[Rifabutin]], [[Secobarbital]], [[Sulfonamides]], [[Thiazides]], [[Tuinal]] | |||
▸ Granulocytopenia — [[Acetazolamide]], [[Aripiprazole]], [[Benzthiazide]], [[Bortezomib]], [[Brinzolamide]], [[Bumetanide]], [[Capecitabine]], [[Captopril]], [[Carbamazepine]], [[Ceftazidime]], [[Celecoxib]], [[Chlorpropamide]], [[Dapsone]], [[Diabinese]], [[Disopyramide]], [[Dorzolamide]], [[Enalapril maleate]], [[Exna]], [[Fosinopril]], [[Fortaz]], [[Glyburide]], [[Lisinopril and Hydrochlorothiazide]], [[Ofloxacin]], [[Penicillin]], [[quinine]], [[Rifabutin]], [[salicylate]], [[Sulfacetamide sodium And Prednisolone acetate]], [[Sulfadiazine]], [[sulfonamides]] | |||
|} | |||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 80%;" align=center | |||
! style="background: #4479BA; padding: 5px 5px; width: 20%;" | {{fontcolor|#FFFFFF|Multiorgan reactions}} | |||
! style="background: #4479BA; padding: 5px 5px; width: 30%;" | {{fontcolor|#FFFFFF|Clinical features}} | |||
! style="background: #4479BA; padding: 5px 5px; width: 50%;" | {{fontcolor|#FFFFFF|Implicated medications}} | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Anaphylaxis | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Abatacept]], [[Abciximab]], [[Acebutolol]], [[Acetazolamide]], [[Acetylcysteine]], [[Albuterol]], [[Aliskiren]], [[Alteplase]], [[Amlodipine and Benazepril]], [[Aminocaproic acid]], [[Anastrozole]], [[Antihemophilic factor]], [[Anti-inhibitor coagulant complex]], [[Aripiprazole]], [[Armodafinil]], [[Atomoxetine]], [[Beclometasone dipropionate]], [[Beta-lactam|β-lactam antibiotics]], [[Betaxolol]], [[Bisoprolol]], [[Bivalirudin]], [[Bortezomib]], [[Buprenorphine Hydrochloride, Naloxone Hydrochloride]], [[monoclonal antibodies]], [[adalimumab]], [[Benazepril]], [[Bendamustine]], [[Captopril]], [[Carteolol]], [[Carvedilol]], [[Celecoxib]], [[Ciclosporin]], [[Ciprofloxacin and Dexamethasone]], [[Cisplatin]], [[Clopidogrel]], [[Cyclobenzaprine]], [[Cyclophosphamide]], [[Dabigatran]], [[Dalteparin]], [[Daptomycin]], [[Darbepoetin Alfa]], [[Denosumab]], [[Desirudin]], [[Dexamethasone]], [[Dexlansoprazole]], [[Dexmethylphenidate]], [[Diflunisal]], [[Digoxin]], [[Digoxin immune fab]], [[Dobutamine]], [[Enalapril maleate]], [[Enoxaparin]], [[epoetin alfa]], [[Erythropoietin]], [[Esmolol]], [[Esomeprazole]], [[Eszopiclone]], [[Etanercept]], [[Ethambutol]], [[Etodolac]], [[Everolimus]], [[Exenatide]], [[Ezetimibe]], [[Factor IX complex]], [[Fenoldopam]], [[Fluconazole]], [[Fluoxetine]], [[Fluphenazine]], [[Fluticasone]], [[Fondaparinux]], [[Furosemide]], [[Glimepiride]], [[Glucagon]], [[Heparin]], [[HPV Vaccine]], [[Hyoscyamine]], [[Ibandronic acid]], [[Infliximab]], [[Insulin glargine]], [[Insulin glulisine]], [[Insulin lispro]], [[Interferon beta-1a]], [[Interferon beta-1b]], [[Iopromide]], [[Ipratropium Bromide And Albuterol]], [[Isotretinoin]], [[Ketorolac tromethamine]], [[Labetalol]], [[Levalbuterol]], [[Lepirudin]], [[Levonorgestrel and Ethinyl estradiol]], [[Linagliptin]], [[Linagliptin and Metformin hydrochloride]], [[Lisinopril and Hydrochlorothiazide]], [[Loperamide]], [[Losartan and Hydrochlorothiazide]], [[Medroxyprogesterone]], [[Mefenamic acid]], [[Meloxicam]], [[Mesna]], [[Metaxalone]], [[Methylphenidate]], [[Methyltestosterone]], [[Metoclopramide]], [[Minocycline hydrochloride]], [[Modafinil]], [[Moxifloxacin]], [[Mupirocin]], [[Nabumetone]], [[Nadolol]], [[Nebivolol]], [[Nitrofurantoin]], [[Ofatumumab]], [[Ofloxacin]], [[Olmesartan]], [[Omalizumab]], [[Ondansetron]], [[Oxytocin]], [[Pegloticase]], [[Penbutolol]], [[Pindolol]], [[Prochlorperazine]], [[Propranolol]], [[Progesterone]], [[Protamine]], [[Rituximab]], [[Rivaroxaban]], [[Saxagliptin]], [[Saxagliptin hydrochloride and Metformin hydrochloride]], [[Solifenacin]], [[Sumatriptan]], [[Tinzaparin]], [[Tocilizumab]], [[Trastuzumab]], [[Triamcinolone]], [[Triamterene]], [[Urokinase]], [[Valganciclovir hydrochloride]], [[Velaglucerase alfa]], [[Zaleplon]], [[Zanamivir]], [[Zidovudine]], [[Zolpidem]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Systemic lupus erythematosus | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Arthralgia, myalgias, fever, malaise | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Armodafinil]], [[Hydralazine]], [[procainamide]], [[isoniazid]], [[propafenone]], [[Levonorgestrel and Ethinyl estradiol]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Vasculitis | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Cutaneous or visceral vasculitis | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Allopurinol]], [[aspirin]], [[Beta-lactam|β-lactam antibiotics]], [[carbamazepine]], [[carbimazole]], [[co-trimoxazole]], [[diltiazem]], [[erythromycin]], [[gold]], [[G-CSF]], [[GM-CSF]], [[Hydralazine]], [[interferons]], [[methotrexate]], [[minocycline]], [[NSAIDs]], [[penicillamine]], [[propylthiouracil]], [[retinoids]], [[sulfasalazine]], [[sulfonamides]], [[thiazides]], [[thrombolytics]], [[Adalimumab]], [[Amiodarone]], [[Cefdinir]], [[Methyldopa]], [[Amoxapine]], [[Moxifloxacin]], [[Fluticasone]], [[Acyclovir]], [[Allopurinol]], [[Amlodipine]], [[Bortezomib]], [[Captopril]], [[Captopril and Hydrochlorothiazide]], [[Chlorothiazide]], [[Chlorthalidone]], [[Clopidogrel]], [[Delavirdine]], [[Enalapril maleate]], [[Filgrastim]], [[Fosinopril]], [[Furosemide]], [[Hydrochlorothiazide]],,[[Imatinib]], [[Isotretinoin]], [[Lisinopril]], [[Lisinopril/Hydrochlorothiazide]], [[Losartan]], [[Lovastatin]], [[Methyclothiazide]], [[Metolazone]], [[Ofloxacin]], [[Pravastatin]], [[Prazosin]], [[Ramipril]], [[Abatacept]], [[Spironolactone]], [[Spironolactone/Hydrochlorothiazide]], [[Ticlopidine]], [[Valsartan]], [[Colchicine]], [[Quinidine]], [[Quinidine gluconate]], [[Dronedarone]], [[Enoxaparin]], [[Thiazide]], [[Fluticasone/salmeterol]], [[Infliximab]], [[Sitagliptin]], [[Enalaprilat]], [[Fluoxetine]], [[Glyburide]], [[Hydrochloride]], [[Hydroflumethiazide]], [[Polythiazide]], [[Valaciclovir]], [[Simvastatin]], [[Losartan and Hydrochlorothiazide]], [[Methylphenidate]], [[Mirabegron]], [[Dexlansoprazole]], [[Sumatriptan]], [[Bisoprolol]], [[Rituximab]], [[Aggrenox]], [[Penicillin G]], [[Norfloxacin]], [[Isoniazid]], [[Penicillin G procaine]], [[Famciclovir]], [[Cefuroxime]], [[Rifampin isoniazid]], [[Rifampin]], [[Interferon alfa-2a]], [[Amoxicillin-clavulanate potassium]], [[Interferon alfa-2a]], [[Pegylated interferon alfa-2a]], [[vancomycin]], [[Atovaquone proguanil]], [[Terbinafine]], [[Indinavir]], [[Ciprofloxacin Hydrochloride]], [[Lamivudine zidovudine]], [[Interferon alfa-2b]], [[Gemifloxacin mesylate]], [[Pentamidine Isethionate]], [[Abacavir lamivudine zidovudine]], [[Nitrofurantoin]], [[Zidovudine]], [[Quinine Sulfate]], [[Valproic acid]], [[Divalproex]], [[Niacin/Simvastatin]], [[Ezetimibe/Simvastatin]], [[Felodipine]], [[Fosinopril/Hydrochlorothiazide]], [[Moexipril/Hydrochlorothiazide]], [[Quinapril/Hydrochlorothiazide]], [[Enalapril maleate/Hydrochlorothiazide]], [[Enalapril/Felodipine]], [[Perindopril]] ,[[Fluvastatin]], [[Diltiazem]], [[Metoprolol succinate and hydrochlorothiazide]], [[Nebivolol]], [[Amiodarone]], [[Olmesartan Medoxomil-Hydrochlorothiazide]], [[Amlodipine Besylate]], [[Divalproex]], [[Pioglitazone/Glimepiride]], [[Aspirin/Dipyridamole]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Serum sickness | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Urticaria, arthralgia, fever | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Heterologous]] [[antibodies]], [[infliximab]], [[Cefdinir]], [[Bupropion]], [[Levothyroxine]], [[Tetracycline hydrochloride]], [[Antivenom]], [[Glatiramer acetate]], [[Antivenin]],,[[Measles]], [[Ticlopidine]], [[Clopidogrel]], [[Novobiocin]], [[Epinephrine]], [[Omalizumab]], [[Rituximab]], [[Immunosuppressive drug]], [[Digoxin]], [[Levothyroxine]], [[Ciprofloxacin]], [[Cefprozil]], [[Cefaclor]], [[Oxacillin]], [[Amoxicillin]], [[Ofloxacin]], [[Penicillin G benzathine]], [[Ampicillin]], [[Ceftibuten]], [[Cefpodoxime]], [[Terbinafine]], [[Gemifloxacin]], [[Metronidazole]], [[Cefadroxil]], [[Doxycycline]], [[Levofloxacin]], [[Minocycline]], [[Moxifloxacin]], [[Sulfadiazine]], [[Lincomycin]], [[Sulfamethoxazole]] | |||
|- | |||
| style="background: #DCDCDC; padding: 5px 5px; font-weight: bold;" valign=top | Drug reaction with eosinophilia and systemic symptoms (DRESS) | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | ▸ Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy | |||
| style="background: #F5F5F5; padding: 5px 5px;" valign=top | [[Allopurinol]], [[anticonvulsant]]s, [[Armodafinil]], [[atazanavir]], [[Carbamazepine]], [[minocycline]], [[sulfonamide]]s, [[spironolactone]] | |||
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==References== | ==References== | ||
Latest revision as of 18:51, 23 February 2015
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Drug Allergy |
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Diagnosis |
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Treatment |
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Case Studies |
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Drug allergy causes On the Web |
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American Roentgen Ray Society Images of Drug allergy causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2], Jolanta Marszalek, M.D. [3]
Overview
The types of drugs that can cause drug allergies vary. Drugs containing sulfa are common in causing drug allergy reactions. Other common drugs implicated in leading to an allergic reaction are antibiotics, insulin, and iodinated drugs.
Causes
Common Causes
When a medication causes an allergic reaction, it is called an allergen. The following is a short list of the most common drug allergens
- Antibiotics
- Analgesics
- Anticonvulsives
Causes by Organ System
Causes in Alphabetical Order
Causes by Specific Allergic Reactions[1][2]
References
- ↑ Khan, David A. (2010-02). "Drug allergy". The Journal of Allergy and Clinical Immunology. 125 (2 Suppl 2): –126-137. doi:10.1016/j.jaci.2009.10.028. ISSN 1097-6825. PMID 20176256. Unknown parameter
|coauthors=ignored (help); Check date values in:|date=(help) - ↑ Lee, Anne (2006). Adverse drug reactions. London Chicago: Pharmaceutical Press. ISBN 0853696012.