Drug allergy epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]

Drug Allergy


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Adverse drug reactions may occur in up to 10% of the worldwide population, and also affect up to 20% of patients who are hospitalized. Of all the cases of fatalities caused by anaphylaxis, drugs may be responsible for 20% of the deaths. The incidence of toxic epidermal necrolysis is about 0.4-1.2 cases per million in a year.

Immediate hypersensitivity are over-reported and few patient reporting these have reactions on careful testing.[1][2]


  1. Macy, Eric (2013-05). "Safely Diagnosing Clinically Significant Penicillin Allergy Using Only Penicilloyl-Poly-Lysine, Penicillin, and Oral Amoxicillin". The Journal of Allergy and Clinical Immunology: In Practice. 1 (3): 258–263. doi:10.1016/j.jaip.2013.02.002. ISSN 2213-2198. Retrieved 2013-07-13. Unknown parameter |coauthors= ignored (help); Check date values in: |date= (help)
  2. Messaad D, Sahla H, Benahmed S, Godard P, Bousquet J, Demoly P (2004). "Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction". Ann Intern Med. 140 (12): 1001–6. PMID 15197017.

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