Thyroid hormone receptor
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| Identifiers | |
| Symbol | THRA |
| Alt. Symbols | THRA1, THRA2, ERBA1 |
| Entrez | 7067 |
| HUGO | 11796 |
| OMIM | 190120 |
| RefSeq | NM_199334 |
| UniProt | P10827 |
| Other data | |
| Locus | Chr. 17 q11.2-17q12 |
| Identifiers | |
| Symbol | THRB |
| Alt. Symbols | ERBA2 |
| Entrez | 7068 |
| HUGO | 11799 |
| OMIM | 190160 |
| RefSeq | NM_000461 |
| UniProt | P10828 |
| Other data | |
| Locus | Chr. 3 p24.1-p22 |
The thyroid hormone receptor[1] is a type of nuclear receptor that is activated by binding thyroid hormone.[1] Among its most important functions are regulation of metabolism and heart rate.[1][1] In addition, it plays a critical role in the development of organisms.
There are three forms of the thyroid hormone receptor designated alpha-1, beta-1 and beta-2 that are able to bind thyroid hormone. There are two TR-alpha receptor splice variants encoded by the THRA gene and two TR-beta isoform splice variants encoded by the THRB gene:
- TR-α1 (widely expressed and especially high expression in cardiac and skeletal muscles)
- TR-α2 (homologous with viral oncogen c-erb-A, also widely expressed but unable to bind hormone)
- TR-β1 (predominately expressed in brain, liver and kidney)
- TR-β2 (expression primarily limited to the hypothalamus and pituitary)
Certain mutations in the thyroid hormone receptor are associated with thyroid hormone resistance.[1]
References
External links
Transcription factors and intracellular receptors | |||||||||||||
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| (1) Basic domains |
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| (2) Zinc finger DNA-binding domains |
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| (3) Helix-turn-helix domains |
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| (4) β-Scaffold factors with minor groove contacts |
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| (0) Other transcription factors |
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fr:récepteur des hormones thyroïdiennes it:Recettore degli ormoni tiroidei
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

