CEBPD

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CCAAT/enhancer binding protein (C/EBP), delta
Identifiers
Symbol(s) CEBPD; C/EBP-delta; CELF; CRP3; NF-IL6-beta
External IDs OMIM: 116898 MGI: 103573 Homologene: 3808
Orthologs
Human Mouse
Entrez 1052 12609


Refseq NM_005195 (mRNA)
NP_005186 (protein) 		NM_007679 (mRNA)
NP_031705 (protein)
Pubmed search [1] [2]

CCAAT/enhancer binding protein (C/EBP), delta, also known as CEBPD, is a human gene.


The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[1]


See also

References

  1. ↑ Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta.

Further reading

  • Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256-9. PMID 1638120.
  • Kinoshita S, Akira S, Kishimoto T (1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1473-6. PMID 1741402.
  • Cao Z, Umek RM, McKnight SL (1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.". Genes Dev. 5 (9): 1538-52. PMID 1840554.
  • Williams SC, Cantwell CA, Johnson PF (1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.". Genes Dev. 5 (9): 1553-67. PMID 1884998.
  • Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).". J. Immunol. 155 (9): 4330-8. PMID 7594592.
  • Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p.". Cytogenet. Cell Genet. 70 (3-4): 188-91. PMID 7789168.
  • Cleutjens CB, van Eekelen CC, van Dekken H, et al. (1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization.". Genomics 16 (2): 520-3. PMID 8314590.
  • Chen PL, Riley DJ, Chen Y, Lee WH (1997). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.". Genes Dev. 10 (21): 2794-804. PMID 8946919.
  • Xia C, Cheshire JK, Patel H, Woo P (1998). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes.". Int. J. Biochem. Cell Biol. 29 (12): 1525-39. PMID 9570146.
  • Zhu Y, Saunders MA, Yeh H, et al. (2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins.". J. Biol. Chem. 277 (9): 6923-8. doi:10.1074/jbc.M108075200. PMID 11741938.
  • Angeloni D, Lee JD, Johnson BE, et al. (2002). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2.". Mol. Cell. Probes 15 (6): 395-7. doi:10.1006/mcpr.2001.0377. PMID 11851384.
  • Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters.". J. Biol. Chem. 277 (41): 38827-37. doi:10.1074/jbc.M206224200. PMID 12177065.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Dearth LR, DeWille J (2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells.". J. Biol. Chem. 278 (13): 11246-55. doi:10.1074/jbc.M207930200. PMID 12554732.
  • Milde-Langosch K, Löning T, Bamberger AM (2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins.". Breast Cancer Res. Treat. 79 (2): 175-85. PMID 12825852.
  • Kovács KA, Steinmann M, Magistretti PJ, et al. (2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation.". J. Biol. Chem. 278 (38): 36959-65. doi:10.1074/jbc.M303147200. PMID 12857754.
  • Chen YW, Hubal MJ, Hoffman EP, et al. (2004). "Molecular responses of human muscle to eccentric exercise.". J. Appl. Physiol. 95 (6): 2485-94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035.
  • Li R, Strohmeyer R, Liang Z, et al. (2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease.". Neurobiol. Aging 25 (8): 991-9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823.
  • Sivko GS, Sanford DC, Dearth LD, et al. (2005). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control.". J. Cell. Biochem. 93 (4): 844-56. doi:10.1002/jcb.20224. PMID 15389878.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP) Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH) ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH) AP-2
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6)
(2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6 HIVEP1
(3) Helix-turn-helix
domains
(3.1) Homeo domain ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7)
(3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3)
(3.4) Heat Shock Factors HSF1
(3.5) Tryptophan clusters ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB
(3.6) TEA domain transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT STAT (1, 2, 3, 4, 5, 6)
(4.3) p53 p53
(4.4) MADS box Mef2 (A, B, C, D) • SRF
(4.7) High mobility group HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain CSDA
(0) Other
transcription factors
(0.2) HMGI(Y) HMGA (1, 2)
(0.3) Pocket domain Rb • RBL1 • RBL2
(0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD
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