CCAAT/enhancer binding protein (C/EBP), beta
|PDB rendering based on 1ci6.|
|Available structures:, , , , , , , ,|
|RNA expression pattern|
CCAAT/enhancer binding protein (C/EBP), beta, also known as CEBPB, is a human gene.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
- Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256-9. PMID 1638120.
- Maytin EV, Habener JF (1998). "Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo.". J. Invest. Dermatol. 110 (3): 238-46. doi:10.1046/j.1523-1747.1998.00123.x. PMID 9506442.
- Cornwall GA, Hsia N (2003). "[Cres (cystatin-related epididymal spermatogenic) gene regulation and function]". Zhonghua Nan Ke Xue 8 (5): 313-8. PMID 12479114.
Transcription factors and intracellular receptors
|(1) Basic domains|
|(2) Zinc finger|
|(4) β-Scaffold factors with|
minor groove contacts
| (0) Other|
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