ELF4

E74-like factor 4 (ets domain transcription factor)
Identifiers
Symbol(s)	ELF4; ELFR; MEF
External IDs	MGI: 1928377 Homologene: 31036
Gene ontology Molecular Function: • transcription factor activity • protein binding • transcription activator activity • sequence-specific DNA binding Cellular Component: • nucleus • PML body Biological Process: • natural killer cell proliferation • NK T cell proliferation • transcription • regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2000	56501
Ensembl	ENSG00000102034	ENSMUSG00000031103
Uniprot	Q99607	Q32MF0
Refseq	NM_001421 (mRNA) NP_001412 (protein)	XM_989007 (mRNA) XP_994101 (protein)
Location	Chr X: 129.03 - 129.07 Mb	Chr X: 44.66 - 44.67 Mb
Pubmed search	[1]	[2]

E74-like factor 4 (ets domain transcription factor), also known as ELF4, is a human gene.

Further reading

• Liu Y, Hedvat CV, Mao S, et al. (2006). "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.". Mol. Cell. Biol. 26 (8): 3114-23. doi:10.1128/MCB.26.8.3114-3123.2006. PMID 16581786.
• Moore SD, Offor O, Ferry JA, et al. (2007). "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).". Leuk. Res. 30 (8): 1037-42. doi:10.1016/j.leukres.2005.10.014. PMID 16303180.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Lu Z, Kim KA, Suico MA, et al. (2004). "MEF up-regulates human beta-defensin 2 expression in epithelial cells.". FEBS Lett. 561 (1-3): 117-21. doi:10.1016/S0014-5793(04)00138-3. PMID 15013761.
• Suico MA, Yoshida H, Seki Y, et al. (2004). "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.". J. Biol. Chem. 279 (18): 19091-8. doi:10.1074/jbc.M312439200. PMID 14976184.
• Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.". J. Biol. Chem. 279 (19): 19512-22. doi:10.1074/jbc.M309074200. PMID 14970218.
• Hedvat CV, Yao J, Sokolic RA, Nimer SD (2004). "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells.". J. Biol. Chem. 279 (8): 6395-400. doi:10.1074/jbc.M307524200. PMID 14625302.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Suico MA, Koyanagi T, Ise S, et al. (2002). "Functional dissection of the ETS transcription factor MEF.". Biochim. Biophys. Acta 1577 (1): 113-20. PMID 12151102.
• Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.". Mol. Cell. Biol. 19 (5): 3635-44. PMID 10207087.
• Aryee DN, Petermann R, Kos K, et al. (1998). "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1.". Gene 210 (1): 71-8. PMID 9524226.
• Miyazaki Y, Sun X, Uchida H, et al. (1996). "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties.". Oncogene 13 (8): 1721-9. PMID 8895518.

External links

• MeSH ELF4+protein,+human