Liver X receptor alpha

Nuclear receptor subfamily 1, group H, member 3
250px
PDB rendering based on 1uhl.
Available structures: 1uhl, 2acl
Identifiers
Symbol(s)	NR1H3; LXR-a; LXRA; RLD-1
External IDs	OMIM: 602423 MGI: 1352462 Homologene: 21165
Gene ontology Molecular Function: • transcription factor activity • steroid hormone receptor activity • transcription coactivator activity • thyroid hormone receptor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular Component: • nucleus Biological Process: • transcription • regulation of transcription, DNA-dependent • negative regulation of transcription • cellular lipid metabolic process
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	10062	22259
Ensembl	ENSG00000025434	ENSMUSG00000002108
Uniprot	Q13133	Q91X41
Refseq	NM_005693 (mRNA) NP_005684 (protein)	NM_013839 (mRNA) NP_038867 (protein)
Location	Chr 11: 47.23 - 47.25 Mb	Chr 2: 90.98 - 91 Mb
Pubmed search	[1]	[2]

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).

Further reading

• Willy PJ, Umesono K, Ong ES, et al. (1995). "LXR, a nuclear receptor that defines a distinct retinoid response pathway.". Genes Dev. 9 (9): 1033-45. PMID 7744246.
• Miyata KS, McCaw SE, Patel HV, et al. (1996). "The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling.". J. Biol. Chem. 271 (16): 9189-92. PMID 8621574.
• Lehmann JM, Kliewer SA, Moore LB, et al. (1997). "Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.". J. Biol. Chem. 272 (6): 3137-40. PMID 9013544.
• Auboeuf D, Rieusset J, Fajas L, et al. (1997). "Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients.". Diabetes 46 (8): 1319-27. PMID 9231657.
• Peet DJ, Turley SD, Ma W, et al. (1998). "Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.". Cell 93 (5): 693-704. PMID 9630215.
• Miyata KS, McCaw SE, Meertens LM, et al. (1999). "Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha.". Mol. Cell. Endocrinol. 146 (1-2): 69-76. PMID 10022764.
• Venkateswaran A, Laffitte BA, Joseph SB, et al. (2000). "Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 12097-102. doi:10.1073/pnas.200367697. PMID 11035776.
• Chinetti G, Lestavel S, Bocher V, et al. (2001). "PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway.". Nat. Med. 7 (1): 53-8. doi:10.1038/83348. PMID 11135616.
• Laffitte BA, Repa JJ, Joseph SB, et al. (2001). "LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 507-12. doi:10.1073/pnas.021488798. PMID 11149950.
• Li Y, Bolten C, Bhat BG, et al. (2002). "Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.". Mol. Endocrinol. 16 (3): 506-14. PMID 11875109.
• Mak PA, Laffitte BA, Desrumaux C, et al. (2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.". J. Biol. Chem. 277 (35): 31900-8. doi:10.1074/jbc.M202993200. PMID 12032151.
• Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.". Mol. Endocrinol. 16 (6): 1367-77. PMID 12040021.
• Steffensen KR, Schuster GU, Parini P, et al. (2002). "Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins.". Biochem. Biophys. Res. Commun. 293 (5): 1333-40. doi:10.1016/S0006-291X(02)00390-X. PMID 12054659.
• Gbaguidi GF, Agellon LB (2002). "The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter.". Biochim. Biophys. Acta 1583 (2): 229-36. PMID 12117567.
• Pawar A, Xu J, Jerks E, et al. (2002). "Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells.". J. Biol. Chem. 277 (42): 39243-50. doi:10.1074/jbc.M206170200. PMID 12161442.
• Brendel C, Schoonjans K, Botrugno OA, et al. (2003). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity.". Mol. Endocrinol. 16 (9): 2065-76. PMID 12198243.
• Oberkofler H, Schraml E, Krempler F, Patsch W (2003). "Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha.". Biochem. J. 371 (Pt 1): 89-96. doi:10.1042/BJ20021665. PMID 12470296.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Wang M, Thomas J, Burris TP, et al. (2004). "Molecular determinants of LXRalpha agonism.". J. Mol. Graph. Model. 22 (2): 173-81. doi:10.1016/S1093-3263(03)00159-1. PMID 12932788.
• Fukuchi J, Song C, Ko AL, Liao S (2004). "Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.". Steroids 68 (7-8): 685-91. PMID 12957674.