CREB1

CAMP responsive element binding protein 1
250px
PDB rendering based on 1dh3.
Available structures: 1dh3
Identifiers
Symbol(s)	CREB1; CREB; MGC9284
External IDs	OMIM: 123810 MGI: 88494 Homologene: 3223
Gene ontology Molecular Function: • transcription factor activity • transcription cofactor activity • sequence-specific DNA binding • protein dimerization activity Cellular Component: • nucleus • transcription factor complex Biological Process: • regulation of transcription, DNA-dependent • signal transduction • axonogenesis • regulation of cell size
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1385	12912
Ensembl	ENSG00000118260	ENSMUSG00000025958
Uniprot	P16220	Q547S9
Refseq	NM_004379 (mRNA) NP_004370 (protein)	NM_009952 (mRNA) NP_034082 (protein)
Location	Chr 2: 208.1 - 208.17 Mb	Chr 1: 64.47 - 64.54 Mb
Pubmed search	[1]	[2]

CAMP responsive element binding protein 1, also known as CREB1, is a human protein and gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This gene encodes a CREB transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

See also

• CREB

Further reading

• Don J, Stelzer G (2003). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis.". Mol. Cell. Endocrinol. 187 (1-2): 115-24. PMID 11988318.
• Pandey SC (2005). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction.". Pharmacol. Ther. 104 (1): 47-58. doi:10.1016/j.pharmthera.2004.08.002. PMID 15500908.
• Wu H, Zhou Y, Xiong ZQ (2007). "Transducer of regulated CREB and late phase long-term synaptic potentiation.". FEBS J. 274 (13): 3218-23. doi:10.1111/j.1742-4658.2007.05891.x. PMID 17565597.
• Kitagawa K (2007). "CREB and cAMP response element-mediated gene expression in the ischemic brain.". FEBS J. 274 (13): 3210-7. doi:10.1111/j.1742-4658.2007.05890.x. PMID 17565598.
• Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain.". FEBS J. 274 (13): 3202-9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
• Siu YT, Jin DY (2007). "CREB--a real culprit in oncogenesis.". FEBS J. 274 (13): 3224-32. doi:10.1111/j.1742-4658.2007.05884.x. PMID 17565603.

External links

• MeSH CREB1+protein,+human

Template:Gene-2-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.