MEF2D

MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)
250px
PDB rendering based on 1c7u.
Available structures: 1c7u, 1egw
Identifiers
Symbol(s)	MEF2D; DKFZp686I1536
External IDs	OMIM: 600663 MGI: 99533 Homologene: 4327
Gene ontology Molecular Function: • nucleotide binding • transcription factor activity • transcription coactivator activity • RNA binding • sequence-specific DNA binding Cellular Component: • nucleus Biological Process: • transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • muscle development
RNA expression pattern
250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	4209	17261
Ensembl	ENSG00000116604	ENSMUSG00000001419
Uniprot	Q14814	Q3URR2
Refseq	NM_005920 (mRNA) NP_005911 (protein)	XM_987375 (mRNA) XP_992469 (protein)
Location	Chr 1: 154.7 - 154.74 Mb	Chr 3: 88.23 - 88.25 Mb
Pubmed search	[1]	[2]

MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D), also known as MEF2D, is a human gene.

See also

• Mef2

Further reading

• Breitbart RE, Liang CS, Smoot LB, et al. (1994). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.". Development 118 (4): 1095-106. PMID 8269842.
• Hobson GM, Krahe R, Garcia E, et al. (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704-11. doi:10.1006/geno.1995.9007. PMID 8575763.
• Ornatsky OI, McDermott JC (1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells.". J. Biol. Chem. 271 (40): 24927-33. PMID 8798771.
• Yang CC, Ornatsky OI, McDermott JC, et al. (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.". Nucleic Acids Res. 26 (20): 4771-7. PMID 9753748.
• Zhao M, New L, Kravchenko VV, et al. (1999). "Regulation of the MEF2 family of transcription factors by p38.". Mol. Cell. Biol. 19 (1): 21-30. PMID 9858528.
• Wang AH, Bertos NR, Vezmar M, et al. (1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.". Mol. Cell. Biol. 19 (11): 7816-27. PMID 10523670.
• Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070-5. doi:10.1073/pnas.080064097. PMID 10737771.
• Kato Y, Zhao M, Morikawa A, et al. (2000). "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.". J. Biol. Chem. 275 (24): 18534-40. doi:10.1074/jbc.M001573200. PMID 10849446.
• Youn HD, Chatila TA, Liu JO (2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis.". EMBO J. 19 (16): 4323-31. doi:10.1093/emboj/19.16.4323. PMID 10944115.
• Slepak TI, Webster KA, Zang J, et al. (2001). "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D.". J. Biol. Chem. 276 (10): 7575-85. doi:10.1074/jbc.M004625200. PMID 11096067.
• Choi SJ, Park SY, Han TH (2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation.". Nucleic Acids Res. 29 (13): 2836-42. PMID 11433030.
• Okamoto S, Li Z, Ju C, et al. (2002). "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3974-9. doi:10.1073/pnas.022036399. PMID 11904443.
• Park SY, Shin HM, Han TH (2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter.". Mol. Immunol. 39 (1-2): 25-30. PMID 12213324.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Linseman DA, Bartley CM, Le SS, et al. (2003). "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.". J. Biol. Chem. 278 (42): 41472-81. doi:10.1074/jbc.M307245200. PMID 12896970.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Grégoire S, Yang XJ (2005). "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.". Mol. Cell. Biol. 25 (6): 2273-87. doi:10.1128/MCB.25.6.2273-2287.2005. PMID 15743823.
• Prima V, Gore L, Caires A, et al. (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia.". Leukemia 19 (5): 806-13. doi:10.1038/sj.leu.2403684. PMID 15744350.

External links

• MeSH MEF2D+protein,+human