MEF2B

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MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B)
250px
PDB rendering based on 1egw.
Available structures: 1egw, 1n6j, 1tqe
Identifiers
Symbol(s) MEF2B; FLJ32599; FLJ46391; RSRFR2
External IDs OMIM: 600661 MGI: 104526 Homologene: 48381
Orthologs
Human Mouse
Entrez 4207 17259


Refseq NM_005919 (mRNA)
NP_005910 (protein) 		NM_001045484 (mRNA)
NP_001038949 (protein)
Pubmed search [1] [2]

MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B), also known as MEF2B, is a human gene.[1]



See also

References

  1. ↑ Entrez Gene: MEF2B MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B).

Further reading

  • Yu YT, Breitbart RE, Smoot LB, et al. (1992). "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.". Genes Dev. 6 (9): 1783-98. PMID 1516833.
  • Pollock R, Treisman R (1992). "Human SRF-related proteins: DNA-binding properties and potential regulatory targets.". Genes Dev. 5 (12A): 2327-41. PMID 1748287.
  • Hobson GM, Krahe R, Garcia E, et al. (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704-11. doi:10.1006/geno.1995.9007. PMID 8575763.
  • Katoh Y, Molkentin JD, Dave V, et al. (1998). "MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.". J. Biol. Chem. 273 (3): 1511-8. PMID 9430690.
  • Iida K, Hidaka K, Takeuchi M, et al. (1999). "Expression of MEF2 genes during human cardiac development.". Tohoku J. Exp. Med. 187 (1): 15-23. PMID 10458488.
  • Youn HD, Sun L, Prywes R, Liu JO (1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.". Science 286 (5440): 790-3. PMID 10531067.
  • Li M, Linseman DA, Allen MP, et al. (2001). "Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.". J. Neurosci. 21 (17): 6544-52. PMID 11517243.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Han A, Pan F, Stroud JC, et al. (2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2.". Nature 422 (6933): 730-4. doi:10.1038/nature01555. PMID 12700764.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
  • Konig S, Hinard V, Arnaudeau S, et al. (2004). "Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation.". J. Biol. Chem. 279 (27): 28187-96. doi:10.1074/jbc.M313932200. PMID 15084602.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
  • Han A, He J, Wu Y, et al. (2005). "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2.". J. Mol. Biol. 345 (1): 91-102. doi:10.1016/j.jmb.2004.10.033. PMID 15567413.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
  • Gong X, Tsai SW, Yan B, Rubin LP (2006). "Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression.". BMC Mol. Biol. 7: 7. doi:10.1186/1471-2199-7-7. PMID 16504037.

External links


Myoglobin.png This protein-related article is a stub. You can help WikiDoc by expanding it.
v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP) Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH) ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH) AP-2
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6)
(2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6 HIVEP1
(3) Helix-turn-helix
domains
(3.1) Homeo domain ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7)
(3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3)
(3.4) Heat Shock Factors HSF1
(3.5) Tryptophan clusters ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB
(3.6) TEA domain transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT STAT (1, 2, 3, 4, 5, 6)
(4.3) p53 p53
(4.4) MADS box Mef2 (A, B, C, D) • SRF
(4.7) High mobility group HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain CSDA
(0) Other
transcription factors
(0.2) HMGI(Y) HMGA (1, 2)
(0.3) Pocket domain Rb • RBL1 • RBL2
(0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD
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