HOXB5

Homeobox B5
250px
PDB rendering based on 1hom.
Available structures: 1hom, 1san
Identifiers
Symbol(s)	HOXB5; HOX2; HHO.C10; HOX2A; HU-1; Hox2.1
External IDs	OMIM: 142960 MGI: 96186 Homologene: 37585
Gene ontology Molecular Function: • transcription factor activity • sequence-specific DNA binding Cellular Component: • nucleus Biological Process: • regulation of transcription, DNA-dependent • multicellular organismal development • anatomical structure morphogenesis • endothelial cell differentiation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3215	15413
Ensembl	ENSG00000120075	ENSMUSG00000038700
Uniprot	P09067	Q9CZV0
Refseq	NM_002147 (mRNA) NP_002138 (protein)	NM_008268 (mRNA) NP_032294 (protein)
Location	Chr 17: 44.02 - 44.03 Mb	Chr 11: 96.12 - 96.12 Mb
Pubmed search	[1]	[2]

Homeobox B5, also known as HOXB5, is a human gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

See also

• Homeobox

Further reading

• Galang CK, Hauser CA (1992). "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product.". New Biol. 4 (5): 558-68. PMID 1355360.
• Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551-3. PMID 1358459.
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. PMID 1973146.
• Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61-9. PMID 1981366.
• Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191-7. PMID 2570724.
• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385-402. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745-56. PMID 2576652.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104-8. PMID 2878432.
• Hart CP, Awgulewitsch A, Fainsod A, et al. (1986). "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.". Cell 43 (1): 9-18. PMID 3000607.
• Xu WM, Gorman PA, Rider SH, et al. (1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8563-7. PMID 3186746.
• Simeone A, Mavilio F, Bottero L, et al. (1986). "A human homoeo box gene specifically expressed in spinal cord during embryonic development.". Nature 320 (6064): 763-5. doi:10.1038/320763a0. PMID 3453105.
• Hauser CA, Joyner AL, Klein RD, et al. (1986). "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.". Cell 43 (1): 19-28. PMID 4075393.
• Levine M, Rubin GM, Tjian R (1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.". Cell 38 (3): 667-73. PMID 6091895.
• Galang CK, Hauser CA (1993). "Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro.". Mol. Cell. Biol. 13 (8): 4609-17. PMID 8101633.
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114-5. PMID 8646877.
• Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177-81. PMID 8688592.
• Sakach M, Safaei R (1997). "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos.". Int. J. Dev. Neurosci. 14 (5): 567-73. PMID 8930688.
• Archavachotikul K, Ciccone TJ, Chinoy MR, et al. (2002). "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation.". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (3): L359-69. doi:10.1152/ajplung.00400.2000. PMID 11839528.
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50-62. doi:10.1002/tera.10009. PMID 11857506.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.

External links

• MeSH HOXB5+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.