TEAD1

TEA domain family member 1 (SV40 transcriptional enhancer factor)
250px
PDB rendering based on 2hzd.
Available structures: 2hzd
Identifiers
Symbol(s)	TEAD1; REF1; AA; TCF13; TEF-1
External IDs	OMIM: 189967 MGI: 101876 Homologene: 2418
Gene ontology Molecular Function: • transcription factor activity • protein binding • transcription activator activity Cellular Component: • nucleus Biological Process: • transcription • regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter
Orthologs
	Human	Mouse
Entrez	7003	21676
Ensembl	ENSG00000187079	ENSMUSG00000055320
Uniprot	P28347	Q3UFP5
Refseq	NM_021961 (mRNA) NP_068780 (protein)	NM_009346 (mRNA) NP_033372 (protein)
Location	Chr 11: 12.72 - 12.92 Mb	Chr 7: 112.47 - 112.69 Mb
Pubmed search	[1]	[2]

TEA domain family member 1 (SV40 transcriptional enhancer factor), also known as TEAD1, is a human gene.

Further reading

• Xiao JH, Davidson I, Matthes H, et al. (1991). "Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1.". Cell 65 (4): 551-68. PMID 1851669.
• Boam DS, Davidson I, Chambon P (1995). "A TATA-less promoter containing binding sites for ubiquitous transcription factors mediates cell type-specific regulation of the gene for transcription enhancer factor-1 (TEF-1).". J. Biol. Chem. 270 (33): 19487-94. PMID 7642633.
• Fossdal R, Magnússon L, Weber JL, Jensson O (1995). "Mapping the locus of atrophia areata, a helicoid peripapillary chorioretinal degeneration with autosomal dominant inheritance, to chromosome 11p15.". Hum. Mol. Genet. 4 (3): 479-83. PMID 7795606.
• Kariya K, Farrance IK, Simpson PC (1994). "Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter.". J. Biol. Chem. 268 (35): 26658-62. PMID 8253797.
• Shimizu N, Smith G, Izumo S (1993). "Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain beta gene.". Nucleic Acids Res. 21 (17): 4103-10. PMID 8396764.
• Stewart AF, Richard CW, Suzow J, et al. (1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family.". Genomics 37 (1): 68-76. PMID 8921372.
• Gupta MP, Amin CS, Gupta M, et al. (1997). "Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression.". Mol. Cell. Biol. 17 (7): 3924-36. PMID 9199327.
• Simmonds AJ, Liu X, Soanes KH, et al. (1999). "Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila.". Genes Dev. 12 (24): 3815-20. PMID 9869635.
• Jacquemin P, Depetris D, Mattei MG, et al. (1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis.". Genomics 55 (1): 127-9. doi:10.1006/geno.1998.5628. PMID 9889009.
• Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.". Development 126 (21): 4807-16. PMID 10518497.
• Gupta M, Kogut P, Davis FJ, et al. (2001). "Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1.". J. Biol. Chem. 276 (13): 10413-22. doi:10.1074/jbc.M008625200. PMID 11136726.
• Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229-41. doi:10.1101/gad.888601. PMID 11358867.
• Carlini LE, Getz MJ, Strauch AR, Kelm RJ (2002). "Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle cells. Suppression of TEF-1 mediated activation by the single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1.". J. Biol. Chem. 277 (10): 8682-92. doi:10.1074/jbc.M109754200. PMID 11751932.
• Maeda T, Gupta MP, Stewart AF (2002). "TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters.". Biochem. Biophys. Res. Commun. 294 (4): 791-7. doi:10.1016/S0006-291X(02)00556-9. PMID 12061776.
• Maeda T, Chapman DL, Stewart AF (2003). "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation.". J. Biol. Chem. 277 (50): 48889-98. doi:10.1074/jbc.M206858200. PMID 12376544.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Thompson M, Andrade VA, Andrade SJ, et al. (2003). "Inhibition of the TEF/TEAD transcription factor activity by nuclear calcium and distinct kinase pathways.". Biochem. Biophys. Res. Commun. 301 (2): 267-74. PMID 12565854.
• Karasseva N, Tsika G, Ji J, et al. (2003). "Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.". Mol. Cell. Biol. 23 (15): 5143-64. PMID 12861002.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Günther S, Mielcarek M, Krüger M, Braun T (2004). "VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation.". Nucleic Acids Res. 32 (2): 791-802. doi:10.1093/nar/gkh248. PMID 14762206.