Activating protein 2
| transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
| |
| Identifiers | |
| Symbol | TFAP2A |
| Alt. Symbols | TFAP2, AP2TF |
| Entrez | 7020 |
| HUGO | 11742 |
| OMIM | 107580 |
| RefSeq | NM_003220 |
| UniProt | P05549 |
| Other data | |
| Locus | Chr. 6 p22.3 |
| transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
| |
| Identifiers | |
| Symbol | TFAP2B |
| Alt. Symbols | AP2-B |
| Entrez | 7021 |
| HUGO | 11743 |
| OMIM | 601601 |
| RefSeq | NM_003221 |
| UniProt | Q92481 |
| Other data | |
| Locus | Chr. 6 p12 |
| transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
| |
| Identifiers | |
| Symbol | TFAP2C |
| Entrez | 7022 |
| HUGO | 11744 |
| OMIM | 601602 |
| RefSeq | NM_003222 |
| UniProt | Q92754 |
| Other data | |
| Locus | Chr. 20 q13.2 |
| transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
| |
| Identifiers | |
| Symbol | TFAP2D |
| Alt. Symbols | TFAP2BL1 |
| Entrez | 83741 |
| HUGO | 15581 |
| OMIM | 610161 |
| RefSeq | NM_172238 |
| UniProt | Q7Z6R9 |
| Other data | |
| Locus | Chr. 6 p12.3 |
| transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
| |
| Identifiers | |
| Symbol | TFAP2E |
| Alt. Symbols | AP2E |
| Entrez | 339488 |
| HUGO | 30774 |
| RefSeq | NM_178548 |
| UniProt | Q6VUC0 |
| Other data | |
| Locus | Chr. 1 p34.3 |
Activating Protein 2 (AP-2) is a family of closely related transcription factors[1][2] which plays a critical role in regulating gene expression during early development.[3]
References
- ↑ Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science 251 (4997): 1067-71. doi:10.1126/science.1998122. PMID 1998122.
- ↑ Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670-82. doi:10.1101/gad.5.4.670. PMID 2010091.
- ↑ Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control". Gene 260 (1-2): 1-12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.
External links
Transcription coregulators | |
|---|---|
| Coactivators | CARM1 - CRTC1 - CBP - NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 - NCOA6 - NCOA7 - PPARGC1A - PPARGC1B - TGFB1I1 |
| Corepressors | NCOR1 - NRIP1 - NCOR2 (SMRT) - PELP-1 - RCOR1 - Rb - SIN3A- SIN3B - Tripartite motif-containing (TRIM24, TRIM28) |
| ATP-dependent remodeling factors | Chromatin Structure Remodeling (RSC) Complex - SWI/SNF |
Cell signaling | |
|---|---|
| Key concepts | Ligand - Signal transduction - Apoptosis - Second messenger system (Ca2+ signaling, Lipid signaling) |
| Processes | Paracrine - Autocrine - Juxtacrine - Neurotransmitters - Endocrine (Neuroendocrine) |
| Types of proteins | Receptor (Transmembrane, Intracellular) - Transcription factor (General, Preinitiation complex, TFIID, TFIIH) - Adaptor protein |
| receptor ligands | hormones, neurotransmitters, cytokines, growth factors |
Transcription factors and intracellular receptors | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (1) Basic domains |
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| (2) Zinc finger DNA-binding domains |
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| (3) Helix-turn-helix domains |
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| (4) β-Scaffold factors with minor groove contacts |
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| (0) Other transcription factors |
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