Activating protein 2

Jump to: navigation, search

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Identifiers
Symbol	TFAP2A
Alt. Symbols	TFAP2, AP2TF
Entrez	7020
HUGO	11742
OMIM	107580
RefSeq	NM_003220
UniProt	P05549
Other data
Locus	Chr. 6 p22.3

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Identifiers
Symbol	TFAP2B
Alt. Symbols	AP2-B
Entrez	7021
HUGO	11743
OMIM	601601
RefSeq	NM_003221
UniProt	Q92481
Other data
Locus	Chr. 6 p12

transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Identifiers
Symbol	TFAP2C
Entrez	7022
HUGO	11744
OMIM	601602
RefSeq	NM_003222
UniProt	Q92754
Other data
Locus	Chr. 20 q13.2

transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
Identifiers
Symbol	TFAP2D
Alt. Symbols	TFAP2BL1
Entrez	83741
HUGO	15581
OMIM	610161
RefSeq	NM_172238
UniProt	Q7Z6R9
Other data
Locus	Chr. 6 p12.3

transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
Identifiers
Symbol	TFAP2E
Alt. Symbols	AP2E
Entrez	339488
HUGO	30774
RefSeq	NM_178548
UniProt	Q6VUC0
Other data
Locus	Chr. 1 p34.3

Activating Protein 2 (AP-2) is a family of closely related transcription factors^[1]^[2] which plays a critical role in regulating gene expression during early development.^[3]

References

↑ Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science 251 (4997): 1067-71. doi:10.1126/science.1998122. PMID 1998122.
↑ Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670-82. doi:10.1101/gad.5.4.670. PMID 2010091.
↑ Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control". Gene 260 (1-2): 1-12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.

External links

MeSH nuclear+receptor+corepressor+2

Error creating thumbnail: /home/webapps/wikidoc/mediawiki-1.19.2/bin/ulimit4.sh: line 4: r: command not found

This biochemistry article is a stub. You can help WikiDoc by expanding it.

v • d • e Transcription coregulators
Coactivators	CARM1 - CRTC1 - CBP - NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 - NCOA6 - NCOA7 - PPARGC1A - PPARGC1B - TGFB1I1
Corepressors	NCOR1 - NRIP1 - NCOR2 (SMRT) - PELP-1 - RCOR1 - Rb - SIN3A- SIN3B - Tripartite motif-containing (TRIM24, TRIM28)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex - SWI/SNF

v • d • e Cell signaling
Key concepts	Ligand - Signal transduction - Apoptosis - Second messenger system (Ca²⁺ signaling, Lipid signaling)
Processes	Paracrine - Autocrine - Juxtacrine - Neurotransmitters - Endocrine (Neuroendocrine)
Types of proteins	Receptor (Transmembrane, Intracellular) - Transcription factor (General, Preinitiation complex, TFIID, TFIIH) - Adaptor protein
receptor ligands	hormones, neurotransmitters, cytokines, growth factors

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP	Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6)
(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys₆	HIVEP1

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7)
(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3)
(3.4) Heat Shock Factors	HSF1
(3.5) Tryptophan clusters	ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB
(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)
(4.3) p53	p53
(4.4) MADS box	Mef2 (A, B, C, D) • SRF
(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain	CSDA

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2)
(0.3) Pocket domain	Rb • RBL1 • RBL2
(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD