Zbtb7, originally named Pokemon, is a gene that may act as a master switch for cancer, and is responsible for the evolution of cancer. The leader of the research team which discovered this, geneticist Pier Paolo Pandolfi from the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City, said the gene is unique in that it is needed for other oncogenes to cause cancer. Discovery of the gene was first published in the January 2005 issue of Nature.
The original name, Pokemon, stands for "POK erythroid myeloid ontogenic factor" and is most likely a backronym of the Pokémon media franchise. Nintendo subsidiary Pokémon USA, not wanting the bad press inherent with its trademark sharing a name with a cancer-causing gene, threatened the center with legal action in December 2005, at which point MSKCC decided to rename it as Zbtb7.
- Sonic hedgehog, a protein named after a video game character.
- ↑ Jai A. Dennison. "Switching Off 'Pokemon' Gene May Block Cancer-Cell Formation", Daily News Central, 2005-01-20. Retrieved on 2006-06-27.
- ↑ Takahiro Maeda, Robin M. Hobbs, et al. (2005-01-20). "Role of the proto-oncogene Pokemon in cellular transformation and ARF repression". Nature (433): 278-285. doi:10.1038/nature03203. Retrieved on 2006-06-27.
- ↑ Brendan Sinclair (2005-12-19). Pokemon USA threatens to sue cancer researchers. GameSpot. Retrieved on 2006-06-27.
Transcription factors and intracellular receptors
|(1) Basic domains|
|(2) Zinc finger|
|(4) β-Scaffold factors with|
minor groove contacts
| (0) Other|
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