ZNF148

Zinc finger protein 148
Identifiers
Symbol(s)	ZNF148; BERF-1; BFCOL1; HT-BETA; ZBP-89; ZFP148; pHZ-52
External IDs	OMIM: 601897 MGI: 1332234 Homologene: 8003
Gene ontology Molecular Function: • nucleic acid binding • DNA binding • specific RNA polymerase II transcription factor activity • zinc ion binding • transcription activator activity • metal ion binding Cellular Component: • intracellular • nucleus • DNA-directed RNA polymerase II, core complex Biological Process: • negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • cellular defense response • gamete generation
Orthologs
	Human	Mouse
Entrez	7707	22661
Ensembl	na	ENSMUSG00000022811
Uniprot	na	Q3UJ69
Refseq	NM_021964 (mRNA) NP_068799 (protein)	NM_011749 (mRNA) NP_035879 (protein)
Location	na	Chr 16: 33.3 - 33.42 Mb
Pubmed search	[1]	[2]

Zinc finger protein 148, also known as ZNF148, is a human gene.

See also

• Zinc finger

Further reading

• Tommerup N, Vissing H (1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.". Genomics 27 (2): 259-64. doi:10.1006/geno.1995.1040. PMID 7557990.
• Wang Y, Kobori JA, Hood L (1993). "The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression.". Mol. Cell. Biol. 13 (9): 5691-701. PMID 8355710.
• Merchant JL, Iyer GR, Taylor BR, et al. (1997). "ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.". Mol. Cell. Biol. 16 (12): 6644-53. PMID 8943318.
• Taniuchi T, Mortensen ER, Ferguson A, et al. (1997). "Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer.". Biochem. Biophys. Res. Commun. 233 (1): 154-60. doi:10.1006/bbrc.1997.6310. PMID 9144414.
• Law DJ, Tarlé SA, Merchant JL (1998). "The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression.". Mamm. Genome 9 (2): 165-7. PMID 9457682.
• Law GL, Itoh H, Law DJ, et al. (1998). "Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter.". J. Biol. Chem. 273 (32): 19955-64. PMID 9685330.
• Antona V, Cammarata G, De Gregorio L, et al. (1999). "The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8.". Cytogenet. Cell Genet. 83 (1-2): 90-2. PMID 9925940.
• Ye S, Whatling C, Watkins H, Henney A (1999). "Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89.". FEBS Lett. 450 (3): 268-72. PMID 10359087.
• Hasegawa T, Takeuchi A, Miyaishi O, et al. (2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters.". Biochem. J. 347 Pt 1: 55-9. PMID 10727401.
• Bai L, Merchant JL (2000). "Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells.". J. Biol. Chem. 275 (39): 30725-33. doi:10.1074/jbc.M004249200. PMID 10899165.
• Bai L, Merchant JL (2001). "ZBP-89 promotes growth arrest through stabilization of p53.". Mol. Cell. Biol. 21 (14): 4670-83. doi:10.1128/MCB.21.14.4670-4683.2001. PMID 11416144.
• Park H, Shelley CS, Arnaout MA (2003). "The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene.". Blood 101 (3): 894-902. doi:10.1182/blood-2002-03-0680. PMID 12393719.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Chen GG, Merchant JL, Lai PB, et al. (2003). "Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89.". Am. J. Pathol. 162 (6): 1823-9. PMID 12759240.
• Wu Y, Diab I, Zhang X, et al. (2004). "Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89.". Oncogene 23 (1): 168-78. doi:10.1038/sj.onc.1207003. PMID 14712222.
• Bai L, Yoon SO, King PD, Merchant JL (2005). "ZBP-89-induced apoptosis is p53-independent and requires JNK.". Cell Death Differ. 11 (6): 663-73. doi:10.1038/sj.cdd.4401393. PMID 14963412.
• Samuelsson L, Stiller C, Friberg C, et al. (2004). "Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5.". J. Invest. Dermatol. 122 (6): 1399-400. doi:10.1046/j.0022-202X.2004.12604.x. PMID 15175029.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.

External links

• MeSH ZNF148+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.