HOXA4

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Homeobox A4
Identifiers
Symbol(s) HOXA4; HOX1; HOX1D
External IDs OMIM: 142953 MGI: 96176 Homologene: 37583
RNA expression pattern

PBB GE HOXA4 206289 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 3201 15401
Ensembl ENSG00000197576 ENSMUSG00000000942
Uniprot Q00056 Q61681
Refseq NM_002141 (mRNA)
NP_002132 (protein) 		NM_008265 (mRNA)
NP_032291 (protein)
Location Chr 7: 27.13 - 27.14 Mb Chr 6: 52.12 - 52.12 Mb
Pubmed search [1] [2]

Homeobox A4, also known as HOXA4, is a human gene.[1]


In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[1]


See also

References

  1. ↑ 1.0 1.1 Entrez Gene: HOXA4 homeobox A4.

Further reading

  • Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551-3. PMID 1358459.
  • Buettner R, Yim SO, Hong YS, et al. (1991). "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.". Mol. Cell. Biol. 11 (7): 3573-83. PMID 1675427.
  • McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. PMID 1973146.
  • Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61-9. PMID 1981366.
  • Ferguson-Smith AC, Fienberg A, Ruddle FH (1989). "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.". Genomics 5 (2): 250-8. PMID 2571574.
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745-56. PMID 2576652.
  • Verlinsky Y, Morozov G, Gindilis V, et al. (1995). "Homeobox gene expression in human oocytes and preembryos.". Mol. Reprod. Dev. 41 (2): 127-32. doi:10.1002/mrd.1080410202. PMID 7654365.
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114-5. PMID 8646877.
  • Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177-81. PMID 8688592.
  • Duluc I, Lorentz O, Fritsch C, et al. (1997). "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells.". J. Cell. Sci. 110 ( Pt 11): 1317-24. PMID 9202392.
  • Stelnicki EJ, Kömüves LG, Kwong AO, et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.". J. Invest. Dermatol. 110 (2): 110-5. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.
  • Verlinsky Y, Morozov G, Verlinsky O, et al. (1998). "Isolation of cDNA libraries from individual human preimplantation embryos.". Mol. Hum. Reprod. 4 (6): 571-5. PMID 9665340.
  • (1999) "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097-108. PMID 9847074.
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50-62. doi:10.1002/tera.10009. PMID 11857506.
  • Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.". Haematologica 87 (6): 569-77. PMID 12031912.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Méchine-Neuville A, Lefebvre O, Bellocq JP, et al. (2003). "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110-7. PMID 12520199.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
  • Strathdee G, Sim A, Parker A, et al. (2007). "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL.". Leukemia 20 (7): 1326-9. doi:10.1038/sj.leu.2404254. PMID 16688227.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Myoglobin.png This protein-related article is a stub. You can help WikiDoc by expanding it.
v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP) Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH) ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH) AP-2
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6)
(2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6 HIVEP1
(3) Helix-turn-helix
domains
(3.1) Homeo domain ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7)
(3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3)
(3.4) Heat Shock Factors HSF1
(3.5) Tryptophan clusters ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB
(3.6) TEA domain transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT STAT (1, 2, 3, 4, 5, 6)
(4.3) p53 p53
(4.4) MADS box Mef2 (A, B, C, D) • SRF
(4.7) High mobility group HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain CSDA
(0) Other
transcription factors
(0.2) HMGI(Y) HMGA (1, 2)
(0.3) Pocket domain Rb • RBL1 • RBL2
(0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD
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