YY1

YY1 transcription factor
250px
PDB rendering based on 1ubd.
Available structures: 1ubd
Identifiers
Symbol(s)	YY1; DELTA; NF-E1; UCRBP; YIN-YANG-1
External IDs	OMIM: 600013 MGI: 99150 Homologene: 2556
Gene ontology Molecular Function: • transcription factor activity • transcription coactivator activity • transcription corepressor activity • protein binding • zinc ion binding • metal ion binding Cellular Component: • intracellular • nucleus • transcription factor complex • PcG protein complex Biological Process: • transcription • regulation of transcription from RNA polymerase II promoter • anterior/posterior pattern formation • antimicrobial humoral response
RNA expression pattern
250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	7528	22632
Ensembl	ENSG00000100811	ENSMUSG00000021264
Uniprot	P25490	Q3TLF0
Refseq	NM_003403 (mRNA) NP_003394 (protein)	NM_009537 (mRNA) NP_033563 (protein)
Location	Chr 14: 99.77 - 99.81 Mb	Chr 12: 109.24 - 109.26 Mb
Pubmed search	[1]	[2]

YY1 transcription factor, also known as YY1, is a human gene.

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

Further reading

• Thomas MJ, Seto E (1999). "Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?". Gene 236 (2): 197-208. PMID 10452940.
• Shi Y, Seto E, Chang LS, Shenk T (1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.". Cell 67 (2): 377-88. PMID 1655281.
• Park K, Atchison ML (1991). "Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9804-8. PMID 1946405.
• Yang WM, Inouye CJ, Seto E (1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity.". J. Biol. Chem. 270 (25): 15187-93. PMID 7541038.
• Lee JS, Galvin KM, See RH, et al. (1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.". Genes Dev. 9 (10): 1188-98. PMID 7758944.
• Zhou Q, Gedrich RW, Engel DA (1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB.". J. Virol. 69 (7): 4323-30. PMID 7769693.
• Zhu W, Lossie AC, Camper SA, Gumucio DL (1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human.". Mamm. Genome 5 (4): 234-6. PMID 7912122.
• Shrivastava A, Saleque S, Kalpana GV, et al. (1994). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.". Science 262 (5141): 1889-92. PMID 8266081.
• Becker KG, Swergold GD, Ozato K, Thayer RE (1994). "Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element.". Hum. Mol. Genet. 2 (10): 1697-702. PMID 8268924.
• Margolis DM, Somasundaran M, Green MR (1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production.". J. Virol. 68 (2): 905-10. PMID 8289393.
• Lee JS, Galvin KM, Shi Y (1993). "Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1.". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6145-9. PMID 8327494.
• Yang WM, Inouye C, Zeng Y, et al. (1996). "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12845-50. PMID 8917507.
• Houbaviy HB, Usheva A, Shenk T, Burley SK (1997). "Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13577-82. PMID 8942976.
• Kalenik JL, Chen D, Bradley ME, et al. (1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1.". Nucleic Acids Res. 25 (4): 843-9. PMID 9016636.
• Cole EG, Gaston K (1997). "A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors.". Nucleic Acids Res. 25 (18): 3705-11. PMID 9278494.
• Yang WM, Yao YL, Sun JM, et al. (1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family.". J. Biol. Chem. 272 (44): 28001-7. PMID 9346952.
• Romerio F, Gabriel MN, Margolis DM (1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF.". J. Virol. 71 (12): 9375-82. PMID 9371597.
• McNeil S, Guo B, Stein JL, et al. (1998). "Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking.". J. Cell. Biochem. 68 (4): 500-10. PMID 9493912.
• Viles JH, Patel SU, Mitchell JB, et al. (1998). "Design, synthesis and structure of a zinc finger with an artificial beta-turn.". J. Mol. Biol. 279 (4): 973-86. doi:10.1006/jmbi.1998.1764. PMID 9642075.
• Yao YL, Dupont BR, Ghosh S, et al. (1998). "Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1.". Nucleic Acids Res. 26 (16): 3776-83. PMID 9685495.