Retinoic acid receptor alpha

Retinoic acid receptor, alpha
250px
PDB rendering based on 1dkf.
Available structures: 1dkf, 1dsz, 1hra
Identifiers
Symbol(s)	RARA; NR1B1; RAR
External IDs	OMIM: 180240 MGI: 97856 Homologene: 20262
Gene ontology Molecular Function: • transcription factor activity • steroid hormone receptor activity • retinoic acid receptor activity • transcription coactivator activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular Component: • nucleus Biological Process: • transcription • regulation of transcription, DNA-dependent • signal transduction
RNA expression pattern
250px 250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	5914	19401
Ensembl	ENSG00000131759	ENSMUSG00000037992
Uniprot	P10276	Q3U3R3
Refseq	NM_001033603 (mRNA) NP_001028775 (protein)	NM_009024 (mRNA) NP_033050 (protein)
Location	Chr 17: 35.72 - 35.77 Mb	Chr 11: 98.75 - 98.79 Mb
Pubmed search	[1]	[2]

Retinoic acid receptor alpha (RAR-alpha), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor encoded by the RARA gene.

See also

• Retinoic acid receptor

Further reading

• Petkovich M, Brand NJ, Krust A, Chambon P (1988). "A human retinoic acid receptor which belongs to the family of nuclear receptors.". Nature 330 (6147): 444-50. doi:10.1038/330444a0. PMID 2825025.
• Sirulnik A, Melnick A, Zelent A, Licht JD (2004). "Molecular pathogenesis of acute promyelocytic leukaemia and APL variants.". Best practice & research. Clinical haematology 16 (3): 387-408. PMID 12935958.
• Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (1992). "Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.". Nature 355 (6359): 446-9. doi:10.1038/355446a0. PMID 1310351.
• Kastner P, Perez A, Lutz Y, et al. (1992). "Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.". EMBO J. 11 (2): 629-42. PMID 1311253.
• Baniahmad A, Köhne AC, Renkawitz R (1992). "A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.". EMBO J. 11 (3): 1015-23. PMID 1347744.
• de Thé H, Lavau C, Marchio A, et al. (1991). "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.". Cell 66 (4): 675-84. PMID 1652369.
• de Thé H, Chomienne C, Lanotte M, et al. (1990). "The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.". Nature 347 (6293): 558-61. doi:10.1038/347558a0. PMID 2170850.
• Brand NJ, Petkovich M, Chambon P (1991). "Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).". Nucleic Acids Res. 18 (23): 6799-806. PMID 2175878.
• Borrow J, Goddard AD, Sheer D, Solomon E (1990). "Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.". Science 249 (4976): 1577-80. PMID 2218500.
• Giguere V, Ong ES, Segui P, Evans RM (1988). "Identification of a receptor for the morphogen retinoic acid.". Nature 330 (6149): 624-9. doi:10.1038/330624a0. PMID 2825036.
• Arveiler B, Petkovich M, Mandel JL, Chambon P (1988). "A PstI RFLP for the human retinoic acid receptor in 17q21.". Nucleic Acids Res. 16 (13): 6252. PMID 2899875.
• Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors.". Nature 377 (6548): 454-7. doi:10.1038/377454a0. PMID 7566127.
• Fisher GJ, Talwar HS, Xiao JH, et al. (1994). "Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin.". J. Biol. Chem. 269 (32): 20629-35. PMID 8051161.
• Anderson LA, Friedman L, Osborne-Lawrence S, et al. (1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21.". Genomics 17 (3): 618-23. doi:10.1006/geno.1993.1381. PMID 8244378.
• Chen Z, Guidez F, Rousselot P, et al. (1994). "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1178-82. PMID 8302850.
• Redner RL, Rush EA, Faas S, et al. (1996). "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.". Blood 87 (3): 882-6. PMID 8562957.
• Kamei Y, Xu L, Heinzel T, et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.". Cell 85 (3): 403-14. PMID 8616895.
• Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.". Biochem. Biophys. Res. Commun. 229 (3): 922-9. doi:10.1006/bbrc.1996.1903. PMID 9005841.
• Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.". J. Biol. Chem. 272 (18): 12062-8. PMID 9115274.