FOXO4

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
PDB rendering based on 1e17.
Available structures: 1e17
Identifiers
Symbol(s)	MLLT7; AFX; AFX1; FOXO4; MGC120490
External IDs	OMIM: 300033 MGI: 1891915 Homologene: 4342
Gene ontology Molecular Function: • transcription factor activity • transcription factor binding • transcription activator activity • enzyme binding • sequence-specific DNA binding Cellular Component: • nucleus • cytosol Biological Process: • G1 phase of mitotic cell cycle • transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • cell cycle • cell cycle arrest • mitotic cell cycle G2/M transition DNA damage checkpoint • multicellular organismal development • striated muscle development • negative regulation of cell proliferation • insulin receptor signaling pathway • negative regulation of angiogenesis • cell differentiation • positive regulation of transcription • negative regulation of smooth muscle cell differentiation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4303	54601
Ensembl	ENSG00000184481	ENSMUSG00000042903
Uniprot	P98177	Q9WVH3
Refseq	NM_005938 (mRNA) NP_005929 (protein)	XM_983128 (mRNA) XP_988222 (protein)
Location	Chr X: 70.23 - 70.24 Mb	Chr X: 97.46 - 97.46 Mb
Pubmed search	[1]	[2]

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7, also known as MLLT7, is a human gene.

See also

• FOX proteins

Further reading

• Parry P, Wei Y, Evans G (1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family.". Genes Chromosomes Cancer 11 (2): 79-84. PMID 7529552.
• Borkhardt A, Repp R, Haas OA, et al. (1997). "Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).". Oncogene 14 (2): 195-202. doi:10.1038/sj.onc.1200814. PMID 9010221.
• Peters U, Haberhausen G, Kostrzewa M, et al. (1997). "AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism.". Hum. Genet. 100 (5-6): 569-72. PMID 9341872.
• Kops GJ, de Ruiter ND, De Vries-Smits AM, et al. (1999). "Direct control of the Forkhead transcription factor AFX by protein kinase B.". Nature 398 (6728): 630-4. doi:10.1038/19328. PMID 10217147.
• Takaishi H, Konishi H, Matsuzaki H, et al. (1999). "Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11836-41. PMID 10518537.
• Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.". Nature 404 (6779): 782-7. doi:10.1038/35008115. PMID 10783894.
• Furuyama T, Nakazawa T, Nakano I, Mori N (2001). "Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.". Biochem. J. 349 (Pt 2): 629-34. PMID 10880363.
• Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2000). "1H, 13C and 15N resonance assignments of the DNA binding domain of the human forkhead transcription factor AFX.". J. Biomol. NMR 17 (2): 181-2. PMID 10921784.
• Nasrin N, Ogg S, Cahill CM, et al. (2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10412-7. doi:10.1073/pnas.190326997. PMID 10973497.
• Brownawell AM, Kops GJ, Macara IG, Burgering BM (2001). "Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.". Mol. Cell. Biol. 21 (10): 3534-46. doi:10.1128/MCB.21.10.3534-3546.2001. PMID 11313479.
• Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2001). "Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4).". Biochemistry 40 (20): 5861-9. PMID 11352721.
• Schuur ER, Loktev AV, Sharma M, et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.". J. Biol. Chem. 276 (36): 33554-60. doi:10.1074/jbc.M105555200. PMID 11435445.
• De Ruiter ND, Burgering BM, Bos JL (2001). "Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.". Mol. Cell. Biol. 21 (23): 8225-35. doi:10.1128/MCB.21.23.8225-8235.2001. PMID 11689711.
• Tang TT, Dowbenko D, Jackson A, et al. (2002). "The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor.". J. Biol. Chem. 277 (16): 14255-65. doi:10.1074/jbc.M110901200. PMID 11777915.
• Yang Z, Whelan J, Babb R, Bowen BR (2002). "An mRNA splice variant of the AFX gene with altered transcriptional activity.". J. Biol. Chem. 277 (10): 8068-75. doi:10.1074/jbc.M106091200. PMID 11779849.
• Kops GJ, Medema RH, Glassford J, et al. (2002). "Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.". Mol. Cell. Biol. 22 (7): 2025-36. PMID 11884591.
• So CW, Cleary ML (2002). "MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function.". Mol. Cell. Biol. 22 (18): 6542-52. PMID 12192052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Tang TT, Lasky LA (2003). "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.". J. Biol. Chem. 278 (32): 30125-35. doi:10.1074/jbc.M302042200. PMID 12761217.
• Crossley LJ (2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1.". J. Leukoc. Biol. 74 (4): 583-92. doi:10.1189/jlb.0103020. PMID 12960271.

External links

• MeSH MLLT7+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.