REL

V-rel reticuloendotheliosis viral oncogene homolog (avian)
Identifiers
Symbol(s)	REL; C-Rel
External IDs	OMIM: 164910 MGI: 97897 Homologene: 2182
Gene ontology Molecular Function: • transcription factor activity • signal transducer activity • protein binding Cellular Component: • nucleus Biological Process: • cytokine production • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of interleukin-12 biosynthetic process • positive regulation of transcription, DNA-dependent
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	5966	19696
Ensembl	ENSG00000162924	ENSMUSG00000020275
Uniprot	Q04864	Q5SQ68
Refseq	NM_002908 (mRNA) NP_002899 (protein)	NM_009044 (mRNA) NP_033070 (protein)
Location	Chr 2: 60.96 - 61 Mb	Chr 11: 23.64 - 23.67 Mb
Pubmed search	[1]	[2]

v-rel reticuloendotheliosis viral oncogene homolog (avian), also known as REL, is a human gene. The protein encoded by the human REL gene is a member of the NF-κB family of transcription factors. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphomas and Hodgkin's lymphomas.

Further reading

• Rayet B, Gélinas C (2000). "Aberrant rel/nfkb genes and activity in human cancer.". Oncogene 18 (49): 6938-47. doi:10.1038/sj.onc.1203221. PMID 10602468.
• Kunsch C, Ruben SM, Rosen CA (1992). "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.". Mol. Cell. Biol. 12 (10): 4412-21. PMID 1406630.
• Neumann M, Tsapos K, Scheppler JA, et al. (1992). "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene 7 (11): 2095-104. PMID 1437141.
• Kochel T, Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro.". Oncogene 7 (3): 567-72. PMID 1549370.
• Ruben SM, Klement JF, Coleman TA, et al. (1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.". Genes Dev. 6 (5): 745-60. PMID 1577270.
• Kumar S, Rabson AB, Gélinas C (1992). "The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.". Mol. Cell. Biol. 12 (7): 3094-106. PMID 1620118.
• Lu D, Thompson JD, Gorski GK, et al. (1991). "Alterations at the rel locus in human lymphoma.". Oncogene 6 (7): 1235-41. PMID 1650444.
• Muchardt C, Seeler JS, Nirula A, et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.". J. Virol. 66 (1): 244-50. PMID 1727488.
• Hansen SK, Nerlov C, Zabel U, et al. (1992). "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.". EMBO J. 11 (1): 205-13. PMID 1740106.
• Davis N, Ghosh S, Simmons DL, et al. (1991). "Rel-associated pp40: an inhibitor of the rel family of transcription factors.". Science 253 (5025): 1268-71. PMID 1891714.
• Lim MY, Davis N, Zhang JY, Bose HR (1990). "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70.". Virology 175 (1): 149-60. PMID 2155506.
• Brownell E, Mittereder N, Rice NR (1989). "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon.". Oncogene 4 (7): 935-42. PMID 2666912.
• Brownell E, O'Brien SJ, Nash WG, Rice N (1986). "Genetic characterization of human c-rel sequences.". Mol. Cell. Biol. 5 (10): 2826-31. PMID 3016517.
• Brownell E, Kozak CA, Fowle JR, et al. (1986). "Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat.". Am. J. Hum. Genet. 39 (2): 194-202. PMID 3529946.
• John S, Reeves RB, Lin JX, et al. (1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.". Mol. Cell. Biol. 15 (3): 1786-96. PMID 7862168.
• Xu X, Gélinas C (1995). "The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells.". Virology 207 (2): 362-8. doi:10.1006/viro.1995.1095. PMID 7886940.
• Mackman N (1994). "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers.". J. Biol. Chem. 269 (42): 26363-7. PMID 7929355.
• Sif S, Gilmore TD (1994). "Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1.". J. Virol. 68 (11): 7131-8. PMID 7933095.
• Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.". Mol. Cell. Biol. 14 (4): 2593-603. PMID 8139561.
• Beg AA, Baldwin AS (1994). "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.". Oncogene 9 (5): 1487-92. PMID 8152812.

External links

• MeSH Genes,+rel