high mobility group AT-hook 1
|Locus||Chr. 6 p21|
high mobility group AT-hook 2
|Locus||Chr. 12 q15|
HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture" (Mayr, SCIENCE)
A recent study has shown variations in HMGA2 to have a moderate association with adult height.
Mayr, Christine, et. al. Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation, SCIENCE VOL 315, 16 Mar 2007
There is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies