Liver receptor homolog-1

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Nuclear receptor subfamily 5, group A, member 2
250px
PDB rendering based on 1yok.
Available structures: 1yok, 1yuc, 1zdu, 2a66, 2ff0
Identifiers
Symbol(s) NR5A2; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; hB1F; hB1F-2
External IDs OMIM: 604453 MGI: 1346834 Homologene: 20827
Orthologs
Human Mouse
Entrez 2494 26424
Ensembl ENSG00000116833 ENSMUSG00000026398
Uniprot O00482 Q1WLP7
Refseq NM_003822 (mRNA)
NP_003813 (protein) 		XM_990082 (mRNA)
XP_995176 (protein)
Location Chr 1: 198.26 - 198.41 Mb Chr 1: 138.66 - 138.78 Mb
Pubmed search [1] [2]

The liver receptor homolog-1 (LRH-1) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR5A2 gene (nuclear receptor subfamily 5, group A, member 2).[1][2]

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3]

References

  1. ↑ Bernier D, Thomassin H, Allard D, et al (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.". Mol. Cell. Biol. 13 (3): 1619-33. PMID 7680097.
  2. ↑ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.". Cytogenet. Cell Genet. 82 (3-4): 269-70. PMID 9858833.
  3. ↑ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.". Trends Cell Biol. 14 (5): 250-60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.

Further reading

  • Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.". Mol. Cell. Biol. 13 (3): 1619-33. PMID 7680097.
  • Wong M, Ramayya MS, Chrousos GP, et al. (1997). "Cloning and sequence analysis of the human gene encoding steroidogenic factor 1.". J. Mol. Endocrinol. 17 (2): 139-47. PMID 8938589.
  • Li M, Xie YH, Kong YY, et al. (1998). "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus.". J. Biol. Chem. 273 (44): 29022-31. PMID 9786908.
  • Galarneau L, Drouin R, Bélanger L (1999). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.". Cytogenet. Cell Genet. 82 (3-4): 269-70. PMID 9858833.
  • Nitta M, Ku S, Brown C, et al. (1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6660-5. PMID 10359768.
  • Goodwin B, Jones SA, Price RR, et al. (2000). "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.". Mol. Cell 6 (3): 517-26. PMID 11030332.
  • Wang ZN, Bassett M, Rainey WE (2001). "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase.". J. Mol. Endocrinol. 27 (2): 255-8. PMID 11564608.
  • Zhang CK, Lin W, Cai YN, et al. (2001). "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene.". Gene 273 (2): 239-49. PMID 11595170.
  • Lee YK, Moore DD (2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner.". J. Biol. Chem. 277 (4): 2463-7. doi:10.1074/jbc.M105161200. PMID 11668176.
  • Clyne CD, Speed CJ, Zhou J, Simpson ER (2002). "Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes.". J. Biol. Chem. 277 (23): 20591-7. doi:10.1074/jbc.M201117200. PMID 11927588.
  • Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.". Mol. Endocrinol. 16 (6): 1367-77. PMID 12040021.
  • Sirianni R, Seely JB, Attia G, et al. (2002). "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes.". J. Endocrinol. 174 (3): R13-7. PMID 12208674.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA (2003). "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.". Mol. Cell 11 (6): 1575-85. PMID 12820970.
  • Privalsky ML (2003). "Activation incarnate.". Dev. Cell 5 (1): 1-2. PMID 12852843.
  • Fayard E, Schoonjans K, Annicotte JS, Auwerx J (2003). "Liver receptor homolog 1 controls the expression of carboxyl ester lipase.". J. Biol. Chem. 278 (37): 35725-31. doi:10.1074/jbc.M302370200. PMID 12853459.
  • Annicotte JS, Fayard E, Swift GH, et al. (2003). "Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.". Mol. Cell. Biol. 23 (19): 6713-24. PMID 12972592.
  • Peng N, Kim JW, Rainey WE, et al. (2004). "The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II.". J. Clin. Endocrinol. Metab. 88 (12): 6020-8. PMID 14671206.
  • Cai YN, Zhou Q, Kong YY, et al. (2004). "LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication.". Cell Res. 13 (6): 451-8. doi:10.1038/sj.cr.7290187. PMID 14728801.
  • Saxena D, Safi R, Little-Ihrig L, Zeleznik AJ (2004). "Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation.". Endocrinology 145 (8): 3821-9. doi:10.1210/en.2004-0423. PMID 15117876.

External links

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP) Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH) ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH) AP-2
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6)
(2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6 HIVEP1
(3) Helix-turn-helix
domains
(3.1) Homeo domain ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7)
(3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3)
(3.4) Heat Shock Factors HSF1
(3.5) Tryptophan clusters ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB
(3.6) TEA domain transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT STAT (1, 2, 3, 4, 5, 6)
(4.3) p53 p53
(4.4) MADS box Mef2 (A, B, C, D) • SRF
(4.7) High mobility group HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain CSDA
(0) Other
transcription factors
(0.2) HMGI(Y) HMGA (1, 2)
(0.3) Pocket domain Rb • RBL1 • RBL2
(0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD
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