CNBP

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CCHC-type zinc finger, nucleic acid binding protein
Identifiers
Symbol(s) CNBP; CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
External IDs OMIM: 116955 MGI: 88431 Homologene: 2567
RNA expression pattern

PBB GE CNBP 206158 s at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 7555 12785
Ensembl ENSG00000169714 ENSMUSG00000030057
Uniprot P62633 Q3U5V2
Refseq NM_003418 (mRNA)
NP_003409 (protein) 		NM_013493 (mRNA)
NP_038521 (protein)
Location Chr 3: 130.37 - 130.39 Mb Chr 6: 87.81 - 87.82 Mb
Pubmed search [1] [2]

CCHC-type zinc finger, nucleic acid binding protein, also known as CNBP, is a human gene.[1]


The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM][1]


References

  1. ↑ 1.0 1.1 Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein.

Further reading

  • Lusis AJ, Rajavashisth TB, Klisak I, et al. (1991). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24.". Genomics 8 (2): 411-4. PMID 2249857.
  • Rajavashisth TB, Taylor AK, Andalibi A, et al. (1989). "Identification of a zinc finger protein that binds to the sterol regulatory element.". Science 245 (4918): 640-3. PMID 2562787.
  • Flink IL, Morkin E (1995). "Organization of the gene encoding cellular nucleic acid-binding protein.". Gene 163 (2): 279-82. PMID 7590281.
  • Warden CH, Krisans SK, Purcell-Huynh D, et al. (1995). "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing.". Genomics 24 (1): 14-9. doi:10.1006/geno.1994.1576. PMID 7896269.
  • Ricker K, Grimm T, Koch MC, et al. (1999). "Linkage of proximal myotonic myopathy to chromosome 3q.". Neurology 52 (1): 170-1. PMID 9921867.
  • Liquori CL, Ricker K, Moseley ML, et al. (2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9.". Science 293 (5531): 864-7. doi:10.1126/science.1062125. PMID 11486088.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • McGrath CF, Buckman JS, Gagliardi TD, et al. (2003). "Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein.". J. Virol. 77 (15): 8524-31. PMID 12857921.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
  • Vallo L, Bonifazi E, Borgiani P, et al. (2005). "Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population.". Mol. Cell. Probes 19 (1): 71-4. doi:10.1016/j.mcp.2004.09.003. PMID 15652222.
  • Botta A, Caldarola S, Vallo L, et al. (2006). "Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2).". Biochim. Biophys. Acta 1762 (3): 329-34. doi:10.1016/j.bbadis.2005.11.004. PMID 16376058.
  • Margolis JM, Schoser BG, Moseley ML, et al. (2006). "DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression.". Hum. Mol. Genet. 15 (11): 1808-15. doi:10.1093/hmg/ddl103. PMID 16624843.
  • Toth C, Dunham C, Suchowersky O, et al. (2007). "Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2.". Muscle Nerve 35 (2): 259-64. doi:10.1002/mus.20685. PMID 17068784.
  • Gerbasi VR, Link AJ (2007). "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation.". Mol. Cell Proteomics 6 (6): 1049-58. doi:10.1074/mcp.M600384-MCP200. PMID 17327219.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP) Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH) ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH) AP-2
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6)
(2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6 HIVEP1
(3) Helix-turn-helix
domains
(3.1) Homeo domain ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7)
(3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3)
(3.4) Heat Shock Factors HSF1
(3.5) Tryptophan clusters ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB
(3.6) TEA domain transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT STAT (1, 2, 3, 4, 5, 6)
(4.3) p53 p53
(4.4) MADS box Mef2 (A, B, C, D) • SRF
(4.7) High mobility group HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain CSDA
(0) Other
transcription factors
(0.2) HMGI(Y) HMGA (1, 2)
(0.3) Pocket domain Rb • RBL1 • RBL2
(0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD
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