FOSL1

FOS-like antigen 1
Identifiers
Symbol(s)	FOSL1; FRA1; fra-1
External IDs	OMIM: 136515 MGI: 107179 Homologene: 3967
Gene ontology Molecular Function: • transcription factor activity • sequence-specific DNA binding • protein dimerization activity Cellular Component: • nucleus Biological Process: • regulation of transcription from RNA polymerase II promoter • chemotaxis • cellular defense response • positive regulation of cell proliferation • response to virus
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	8061	14283
Ensembl	ENSG00000175592	ENSMUSG00000024912
Uniprot	P15407	Q3UMA0
Refseq	NM_005438 (mRNA) NP_005429 (protein)	NM_010235 (mRNA) NP_034365 (protein)
Location	Chr 11: 65.42 - 65.42 Mb	Chr 19: 5.45 - 5.46 Mb
Pubmed search	[1]	[2]

FOS-like antigen 1, also known as FOSL1, is a human gene.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

See also

• AP-1 (transcription factor)

Further reading

• Herdegen T, Leah JD (1999). "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.". Brain Res. Brain Res. Rev. 28 (3): 370-490. PMID 9858769.
• Reddy SP, Mossman BT (2002). "Role and regulation of activator protein-1 in toxicant-induced responses of the lung.". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (6): L1161-78. doi:10.1152/ajplung.00140.2002. PMID 12424143.
• Matsui M, Tokuhara M, Konuma Y, et al. (1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.". Oncogene 5 (3): 249-55. PMID 2107490.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
• Tsuchiya H, Fujii M, Niki T, et al. (1993). "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals.". J. Virol. 67 (12): 7001-7. PMID 8230424.
• Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1994). "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13.". Genomics 18 (1): 165. PMID 8276409.
• Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1).". Genomics 37 (3): 354-65. PMID 8938448.
• Arts J, Herr I, Lansink M, et al. (1997). "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro.". Nucleic Acids Res. 25 (2): 311-7. PMID 9016559.
• Pognonec P, Boulukos KE, Aperlo C, et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity.". Oncogene 14 (17): 2091-8. doi:10.1038/sj.onc.1201046. PMID 9160889.
• Smith CM, Ma NS, Nowak NJ, et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13.". Genome Res. 7 (8): 835-42. PMID 9267807.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
• Puntschart A, Wey E, Jostarndt K, et al. (1998). "Expression of fos and jun genes in human skeletal muscle after exercise.". Am. J. Physiol. 274 (1 Pt 1): C129-37. PMID 9458721.
• Finzer P, Soto U, Delius H, et al. (2000). "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition.". Oncogene 19 (29): 3235-44. doi:10.1038/sj.onc.1203643. PMID 10918580.
• Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.". Biochem. Biophys. Res. Commun. 289 (1): 25-33. doi:10.1006/bbrc.2001.5929. PMID 11708771.
• Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.". J. Biol. Chem. 277 (24): 21158-66. doi:10.1074/jbc.M112145200. PMID 11912197.
• Wang HL, Wang J, Xiao SY, et al. (2002). "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.". Int. J. Cancer 101 (4): 301-10. doi:10.1002/ijc.10630. PMID 12209953.
• Bergman MR, Cheng S, Honbo N, et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.". Biochem. J. 369 (Pt 3): 485-96. doi:10.1042/BJ20020707. PMID 12371906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.

External links

• MeSH FOSL1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.