HOXB3

Homeobox B3
Identifiers
Symbol(s)	HOXB3; HOX2; HOX2G; Hox-2.7
External IDs	OMIM: 142966 MGI: 96184 Homologene: 1617
Gene ontology Molecular Function: • transcription factor activity • sequence-specific DNA binding Cellular Component: • nucleus Biological Process: • regulation of transcription, DNA-dependent • multicellular organismal development
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3213	15410
Ensembl	ENSG00000120093	ENSMUSG00000048763
Uniprot	P14651	P09026
Refseq	NM_002146 (mRNA) NP_002137 (protein)	NM_001079869 (mRNA) NP_001073338 (protein)
Location	Chr 17: 43.98 - 44.01 Mb	Chr 11: 96.16 - 96.16 Mb
Pubmed search	[1]	[2]

Homeobox B3, also known as HOXB3, is a human gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551-3. PMID 1358459.
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. PMID 1973146.
• Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191-7. PMID 2570724.
• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385-402. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745-56. PMID 2576652.
• Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". EMBO J. 13 (14): 3339-47. PMID 7913891.
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114-5. PMID 8646877.
• Bingle CD, Gowan S (1996). "Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter.". Biochem. J. 319 ( Pt 3): 669-74. PMID 8920965.
• Sauvageau G, Thorsteinsdottir U, Hough MR, et al. (1997). "Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.". Immunity 6 (1): 13-22. PMID 9052833.
• Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells.". J. Biol. Chem. 273 (18): 11092-9. PMID 9556594.
• Viganò MA, Di Rocco G, Zappavigna V, Mavilio F (1998). "Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.". Mol. Cell. Biol. 18 (11): 6201-12. PMID 9774637.
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50-62. doi:10.1002/tera.10009. PMID 11857506.
• Nakamura N, Yoshimi T, Miura T (2002). "Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3.". Cell Growth Differ. 13 (4): 195-203. PMID 11971819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Pineault N, Abramovich C, Ohta H, Humphries RK (2004). "Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.". Mol. Cell. Biol. 24 (5): 1907-17. PMID 14966272.
• Roche J, Zeng C, Barón A, et al. (2004). "Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics.". Leukemia 18 (6): 1059-63. doi:10.1038/sj.leu.2403366. PMID 15085154.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
• Speleman F, Cauwelier B, Dastugue N, et al. (2005). "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.". Leukemia 19 (3): 358-66. doi:10.1038/sj.leu.2403657. PMID 15674412.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.

External links

• MeSH HOXB3+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.