NKX3-1

NK3 transcription factor related, locus 1 (Drosophila)
Identifiers
Symbol(s)	NKX3-1; BAPX2; NKX3; NKX3.1; NKX3A
External IDs	OMIM: 602041 MGI: 97352 Homologene: 4494
Gene ontology Molecular Function: • transcription factor activity • transcription factor binding • transcription activator activity • sequence-specific DNA binding Cellular Component: • nucleus Biological Process: • regulation of transcription, DNA-dependent • multicellular organismal development • salivary gland development • prostate gland development
RNA expression pattern
250px 250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	4824	18095
Ensembl	ENSG00000167034	ENSMUSG00000022061
Uniprot	Q99801	Q3UVH8
Refseq	NM_006167 (mRNA) NP_006158 (protein)	NM_010921 (mRNA) NP_035051 (protein)
Location	Chr 8: 23.59 - 23.6 Mb	Chr 14: 68.14 - 68.15 Mb
Pubmed search	[1]	[2]

NK3 transcription factor related, locus 1 (Drosophila), also known as NKX3-1, is a human gene.

The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM]

Further reading

• Shen MM, Abate-Shen C (2004). "Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis.". Dev. Dyn. 228 (4): 767-78. doi:10.1002/dvdy.10397. PMID 14648854.
• Abdulkadir SA (2006). "Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1.". Ann. N. Y. Acad. Sci. 1059: 33-40. doi:10.1196/annals.1339.018. PMID 16382041.
• He WW, Sciavolino PJ, Wing J, et al. (1997). "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer.". Genomics 43 (1): 69-77. doi:10.1006/geno.1997.4715. PMID 9226374.
• Voeller HJ, Augustus M, Madike V, et al. (1997). "Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.". Cancer Res. 57 (20): 4455-9. PMID 9377551.
• Prescott JL, Blok L, Tindall DJ (1998). "Isolation and androgen regulation of the human homeobox cDNA, NKX3.1.". Prostate 35 (1): 71-80. PMID 9537602.
• Choi CY, Kim YH, Kwon HJ, Kim Y (1999). "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.". J. Biol. Chem. 274 (47): 33194-7. PMID 10559189.
• Carson JA, Fillmore RA, Schwartz RJ, Zimmer WE (2001). "The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor.". J. Biol. Chem. 275 (50): 39061-72. doi:10.1074/jbc.M006532200. PMID 10993896.
• Bowen C, Bubendorf L, Voeller HJ, et al. (2000). "Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.". Cancer Res. 60 (21): 6111-5. PMID 11085535.
• Korkmaz KS, Korkmaz CG, Ragnhildstveit E, et al. (2001). "Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens.". Gene 260 (1-2): 25-36. PMID 11137288.
• Chen H, Nandi AK, Li X, Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.". Cancer Res. 62 (2): 338-40. PMID 11809674.
• Filmore RA, Dean DA, Zimmer WE (2003). "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia.". Gene Expr. 10 (5-6): 201-11. PMID 12450213.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Gelmann EP, Bowen C, Bubendorf L (2003). "Expression of NKX3.1 in normal and malignant tissues.". Prostate 55 (2): 111-7. doi:10.1002/pros.10210. PMID 12661036.
• Skotheim RI, Korkmaz KS, Klokk TI, et al. (2004). "NKX3.1 expression is lost in testicular germ cell tumors.". Am. J. Pathol. 163 (6): 2149-54. PMID 14633588.
• Korkmaz CG, Korkmaz KS, Manola J, et al. (2004). "Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis.". J. Urol. 172 (3): 1134-9. doi:10.1097/01.ju.0000136526.78535.b8. PMID 15311057.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Chen H, Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF.". J. Cell. Biochem. 94 (1): 168-77. doi:10.1002/jcb.20297. PMID 15523673.
• Lind GE, Skotheim RI, Fraga MF, et al. (2005). "The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation.". Mol. Cancer 4 (1): 8. doi:10.1186/1476-4598-4-8. PMID 15691383.
• Asatiani E, Huang WX, Wang A, et al. (2005). "Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer.". Cancer Res. 65 (4): 1164-73. doi:10.1158/0008-5472.CAN-04-2688. PMID 15734999.

External links

• MeSH NKX3-1+protein,+human

Template:Gene-8-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.