RAR-related orphan receptor beta

RAR-related orphan receptor B
250px
PDB rendering based on 1k4w.
Available structures: 1k4w, 1n4h, 1nq7
Identifiers
Symbol(s)	RORB; NR1F2; ROR-BETA; RZRB; bA133M9.1
External IDs	OMIM: 601972 MGI: 1343464 Homologene: 38250
Gene ontology Molecular Function: • transcription factor activity • steroid hormone receptor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular Component: • nucleus Biological Process: • transcription • regulation of transcription, DNA-dependent • multicellular organismal development • visual perception • eye photoreceptor cell development • positive regulation of gene-specific transcription • response to stimulus
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6096	225998
Ensembl	ENSG00000198963	ENSMUSG00000036192
Uniprot	Q92753	Q8R1B8
Refseq	NM_006914 (mRNA) NP_008845 (protein)	NM_001043354 (mRNA) NP_001036819 (protein)
Location	Chr 9: 76.3 - 76.49 Mb	Chr 19: 19 - 19.06 Mb
Pubmed search	[1]	[2]

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor encoded by the RORB gene.

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.

Further reading

• Beeson WM, Perry TW, Zurcher TD (1977). "Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle.". J. Anim. Sci. 45 (1): 160-5. PMID 885817.
• Giguère V, Tini M, Flock G, et al. (1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.". Genes Dev. 8 (5): 538-53. PMID 7926749.
• Carlberg C, Hooft van Huijsduijnen R, Staple JK, et al. (1994). "RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.". Mol. Endocrinol. 8 (6): 757-70. PMID 7935491.
• Greiner EF, Kirfel J, Greschik H, et al. (1996). "Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10105-10. PMID 8816759.
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.". Biochem. Biophys. Res. Commun. 227 (1): 82-7. doi:10.1006/bbrc.1996.1471. PMID 8858107.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
• Park HT, Baek SY, Kim BS, et al. (1997). "Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat.". Neurosci. Lett. 217 (1): 17-20. PMID 8905729.
• André E, Conquet F, Steinmayr M, et al. (1998). "Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice.". EMBO J. 17 (14): 3867-77. doi:10.1093/emboj/17.14.3867. PMID 9670004.
• Greiner EF, Kirfel J, Greschik H, et al. (2000). "Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7160-5. PMID 10860982.
• Gawlas K, Stunnenberg HG (2001). "Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1).". Biochim. Biophys. Acta 1494 (3): 236-41. PMID 11121580.
• Gawlas K, Stunnenberg HG (2001). "Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells.". Nucleic Acids Res. 29 (16): 3424-32. PMID 11504880.
• Stehlin C, Wurtz JM, Steinmetz A, et al. (2001). "X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.". EMBO J. 20 (21): 5822-31. doi:10.1093/emboj/20.21.5822. PMID 11689423.
• Sumi Y, Yagita K, Yamaguchi S, et al. (2002). "Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus.". Neurosci. Lett. 320 (1-2): 13-6. PMID 11849752.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Stehlin-Gaon C, Willmann D, Zeyer D, et al. (2003). "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.". Nat. Struct. Biol. 10 (10): 820-5. doi:10.1038/nsb979. PMID 12958591.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.