Myogenic regulatory factors

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Myogenic regulatory factors are basic-helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4[1].

These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif [2]. They dimerize with other HLH containing proteins through a HLH-HLH interaction[3].


  1. Perry R, Rudnick M. "Molecular mechanisms regulating myogenic determination and differentiation". Front Biosci. 5: D750–67. PMID 10966875.
  2. Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell T, Turner D, Rupp R, Hollenberg S (1991). "The myoD gene family: nodal point during specification of the muscle cell lineage". Science. 251 (4995): 761–6. PMID 1846704.
  3. Barndt R, Zhuang Y. "Controlling lymphopoiesis with a combinatorial E-protein code". Cold Spring Harb Symp Quant Biol. 64: 45–50. PMID 11232321.

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