Tiratricol

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Tiratricol
Systematic (IUPAC) name
[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
Identifiers
CAS number 51-24-1
ATC code H03AA04 D11AX08
PubChem 5803
DrugBank DB03604
Chemical data
Formula C14H9I3O4 
Mol. mass 621.932 g/mol
SMILES eMolecules & PubChem
Synonyms 3,3',5-triiodothyroacetic acid
TRIAC
Pharmacokinetic data
Bioavailability  ?
Protein binding Presumed high
Metabolism Hepatic glucuronidation
Half life  ?
Excretion Biliary
Therapeutic considerations
Pregnancy cat.

?

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Routes  ?

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.

Uses

It is indicated in the management of thyroid hormone resistance syndrome[1] and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer.

It has been investigated for use in reducing goiter.[2]

It has also shown some effectiveness in reducing the atrophy caused when using corticosteroids.[3]

Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol.[4][5]

Legal status

Tiratricol is not approved for sale in Canada or the United States. It was once an approved drug in Brazil, but its marketing authorization was suspended in 2003, effectively prohibiting its sale.[6] Tiratricol is still available in France for therapy of thyroid hormone resistance and adjuvant therapy of thyroid cancer.[7] It is available as an orphan drug to be prescribed by registered specialists in Europe.

References

  1. Carvalho GA, Ramos HE (2004). "[Thyroid hormone resistance syndrome]" (in Portuguese). Arq Bras Endocrinol Metabol 48 (1): 83–92. doi:10.1590/S0004-27302004000100010. PMID 15611821. Free full textPDF (95.3 KiB)
  2. Brenta G, Schnitman M, Fretes O, et al. (November 2003). "Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid". J. Clin. Endocrinol. Metab. 88 (11): 5287–92. doi:10.1210/jc.2003-030095. PMID 14602763.
  3. Yazdanparast P, Carlsson B, Oikarinen A, Risteli J, Lavin T, Faergemann J (November 2006). "Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans". Thyroid 16 (11): 1157–62. doi:10.1089/thy.2006.16.1157. PMID 17123343.
  4. U.S. Food and Drug Administration (November 21, 2000). FDA Warns Against Consuming Dietary Supplements Containing Tiratricol. Press release. Retrieved on 2007-08-08.
  5. Health Canada (December 2, 1999). Health Canada issues warning on products containing Tiratricol (TRIAC). Press release. Retrieved on 2007-08-08.
  6. Anvisa suspende Tiratricol (Portuguese). Brazilian Society of Endocrinology and Metabolism. Archived from the original on 2007-10-09. Retrieved on 2007-08-08.
  7. Laboratoires DB PHARMA: Teatrois information

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