Tiratricol

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Tiratricol
Systematic (IUPAC) name
2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]
acetic acid
Identifiers
CAS number 51-24-1
ATC code H03AA04 D11AX08
PubChem 5803
Chemical data
Formula C14H9I3O4 
Mol. mass 621.932 g/mol
Synonyms 3,3',5-triiodothyroacetic acid
TRIAC
Pharmacokinetic data
Bioavailability  ?
Protein binding Presumed high
Metabolism Hepatic glucuronidation
Half life  ?
Excretion Biliary
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

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Tiratricol

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Overview

Tiratricol (also known as TRIAC) is a thyroid hormone analogue. It is indicated in the management of thyroid hormone resistance syndrome[1] and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer.

Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol.[2][3]

Legal status

Tiratricol is not approved for sale in Canada or the United States. It was once an approved drug in Brazil, but its marketing authorization was suspended in 2003, effectively prohibiting its sale.[4]

References

  1. Carvalho GA, Ramos HE (2004). "[Thyroid hormone resistance syndrome]" (in Portuguese). Arq Bras Endocrinol Metabol 48 (1): 83–92. doi:/S0004-27302004000100010. PMID 15611821. Free full textPDF (95.3 KiB)
  2. U.S. Food and Drug Administration (November 21 2000). FDA Warns Against Consuming Dietary Supplements Containing Tiratricol. Press release.
  3. Health Canada (December 2 1999). Health Canada issues warning on products containing Tiratricol (TRIAC). Press release.
  4. Anvisa suspende Tiratricol (Portuguese). Brazilian Society of Endocrinology and Metabolism.

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