COUP-TFII

Nuclear receptor subfamily 2, group F, member 2
Identifiers
Symbol(s)	NR2F2; ARP1; COUP-TFII; COUPTFB; MGC117452; SVP40; TFCOUP2
External IDs	OMIM: 107773 MGI: 1352452 Homologene: 7628
Gene ontology Molecular Function: • transcription factor activity • ligand-regulated transcription factor activity • steroid hormone receptor activity • transcription corepressor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular Component: • nucleus Biological Process: • neuron migration • transcription • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • lipid metabolic process • signal transduction • anterior/posterior pattern formation • radial pattern formation • forebrain development • blood vessel morphogenesis • skeletal muscle development
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7026	11819
Ensembl	ENSG00000185551	ENSMUSG00000030551
Uniprot	P24468	Q3UST6
Refseq	NM_021005 (mRNA) NP_066285 (protein)	NM_009697 (mRNA) NP_033827 (protein)
Location	Chr 15: 94.67 - 94.68 Mb	Chr 7: 70.23 - 70.24 Mb
Pubmed search	[1]	[2]

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a human protein encoded by the NR2F2 gene.

Further reading

• De Martino MU, Alesci S, Chrousos GP, Kino T (2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism.". Ann. N. Y. Acad. Sci. 1024: 72-85. doi:10.1196/annals.1321.006. PMID 15265774.
• Mietus-Snyder M, Sladek FM, Ginsburg GS, et al. (1992). "Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.". Mol. Cell. Biol. 12 (4): 1708-18. PMID 1312668.
• Wang LH, Ing NH, Tsai SY, et al. (1992). "The COUP-TFs compose a family of functionally related transcription factors.". Gene Expr. 1 (3): 207-16. PMID 1820218.
• Ladias JA, Karathanasis SK (1991). "Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily.". Science 251 (4993): 561-5. PMID 1899293.
• Qiu Y, Krishnan V, Zeng Z, et al. (1996). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.". Genomics 29 (1): 240-6. PMID 8530078.
• Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor.". J. Biol. Chem. 271 (44): 27197-200. PMID 8910285.
• Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.". J. Biol. Chem. 272 (18): 12062-8. PMID 9115274.
• Chu K, Zingg HH (1998). "The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter.". J. Mol. Endocrinol. 19 (2): 163-72. PMID 9343308.
• Bailey P, Sartorelli V, Hamamori Y, Muscat GE (1999). "The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD.". Nucleic Acids Res. 26 (23): 5501-10. PMID 9826778.
• Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.". J. Biol. Chem. 274 (20): 14331-6. PMID 10318855.
• Smirnov DA, Hou S, Ricciardi RP (2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription.". Virology 268 (2): 319-28. doi:10.1006/viro.1999.0181. PMID 10704340.
• Avram D, Fields A, Pretty On Top K, et al. (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.". J. Biol. Chem. 275 (14): 10315-22. PMID 10744719.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Jordan EM, Worley T, Breen GA (2003). "Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1.". Biochemistry 42 (9): 2656-63. doi:10.1021/bi0268347. PMID 12614160.
• Sato Y, Suzuki T, Hidaka K, et al. (2003). "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle.". J. Clin. Endocrinol. Metab. 88 (7): 3415-20. PMID 12843196.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Kurihara I, Shibata H, Kobayashi S, et al. (2005). "Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.". J. Biol. Chem. 280 (8): 6721-30. doi:10.1074/jbc.M411820200. PMID 15611122.
• Shibata H, Kobayashi S, Kurihara I, et al. (2005). "COUP-TF and transcriptional co-regulators in adrenal steroidogenesis.". Endocr. Res. 30 (4): 795-801. PMID 15666827.