HLF (gene): Difference between revisions

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{{DISPLAYTITLE:''HLF'' (gene)}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Hepatic leukemia factor''' is a [[protein]] that in humans is encoded by the ''HLF'' [[gene]].<ref name="pmid1386162">{{cite journal | vauthors = Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT | title = Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia | journal = Science | volume = 257 | issue = 5069 | pages = 531–4 | date = July 1992 | pmid = 1386162 | pmc = | doi = 10.1126/science.1386162 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Hepatic leukemia factor
| HGNCid = 4977
| Symbol = HLF
| AltSymbols =; MGC33822
| OMIM = 142385
| ECnumber = 
| Homologene = 31074
| MGIid = 96108
| GeneAtlas_image1 = PBB_GE_HLF_204753_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HLF_204754_at_tn.png
| GeneAtlas_image3 = PBB_GE_HLF_204755_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0048511 |text = rhythmic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3131
    | Hs_Ensembl = ENSG00000108924
    | Hs_RefseqProtein = NP_002117
    | Hs_RefseqmRNA = NM_002126
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 50697370
    | Hs_GenLoc_end = 50755863
    | Hs_Uniprot = Q16534
    | Mm_EntrezGene = 217082
    | Mm_Ensembl = ENSMUSG00000003949
    | Mm_RefseqmRNA = NM_172563
    | Mm_RefseqProtein = NP_766151
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 90154655
    | Mm_GenLoc_end = 90206985
    | Mm_Uniprot = Q5SR29
  }}
}}
'''Hepatic leukemia factor''', also known as '''HLF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the [[proline]] and [[acid]]ic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the [[proline]] and [[acid]]ic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HLF hepatic leukemia factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = LeBrun DP | title = E2A basic helix-loop-helix transcription factors in human leukemia | journal = Frontiers in Bioscience | volume = 8 | issue =  | pages = s206-22 | date = May 2003 | pmid = 12700034 | doi = 10.2741/1030 }}
| citations =
* {{cite journal | vauthors = Hunger SP, Ohyashiki K, Toyama K, Cleary ML | title = Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia | journal = Genes & Development | volume = 6 | issue = 9 | pages = 1608–20 | date = September 1992 | pmid = 1516826 | doi = 10.1101/gad.6.9.1608 }}
*{{cite journal | author=LeBrun DP |title=E2A basic helix-loop-helix transcription factors in human leukemia. |journal=Front. Biosci. |volume=8 |issue=  |pages= s206-22 |year= 2004 |pmid= 12700034 |doi= }}
* {{cite journal | vauthors = Falvey E, Fleury-Olela F, Schibler U | title = The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences | journal = The EMBO Journal | volume = 14 | issue = 17 | pages = 4307–17 | date = September 1995 | pmid = 7556072 | pmc = 394515 | doi =  }}
*{{cite journal  | author=Inaba T, Roberts WM, Shapiro LH, ''et al.'' |title=Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. |journal=Science |volume=257 |issue= 5069 |pages= 531-4 |year= 1992 |pmid= 1386162 |doi=  }}
* {{cite journal | vauthors = Hunger SP, Brown R, Cleary ML | title = DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF | journal = Molecular and Cellular Biology | volume = 14 | issue = 9 | pages = 5986–96 | date = September 1994 | pmid = 8065331 | pmc = 359124 | doi = 10.1128/mcb.14.9.5986 }}
*{{cite journal | author=Hunger SP, Ohyashiki K, Toyama K, Cleary ML |title=Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. |journal=Genes Dev. |volume=6 |issue= 9 |pages= 1608-20 |year= 1992 |pmid= 1516826 |doi= }}
* {{cite journal | vauthors = Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashmun RA, Look AT | title = DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein | journal = Molecular and Cellular Biology | volume = 14 | issue = 5 | pages = 3403–13 | date = May 1994 | pmid = 8164688 | pmc = 358705 | doi =  }}
*{{cite journal | author=Falvey E, Fleury-Olela F, Schibler U |title=The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4307-17 |year= 1995 |pmid= 7556072 |doi=  }}
* {{cite journal | vauthors = Hunger SP | title = Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis | journal = Blood | volume = 87 | issue = 4 | pages = 1211–24 | date = February 1996 | pmid = 8608207 | doi =  }}
*{{cite journal | author=Hunger SP, Brown R, Cleary ML |title=DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. |journal=Mol. Cell. Biol. |volume=14 |issue= 9 |pages= 5986-96 |year= 1994 |pmid= 8065331 |doi= }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Inaba T, Shapiro LH, Funabiki T, ''et al.'' |title=DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. |journal=Mol. Cell. Biol. |volume=14 |issue= 5 |pages= 3403-13 |year= 1994 |pmid= 8164688 |doi=  }}
* {{cite journal | vauthors = Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML | title = The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties | journal = Blood | volume = 87 | issue = 11 | pages = 4607–17 | date = June 1996 | pmid = 8639829 | doi =  }}
*{{cite journal | author=Hunger SP |title=Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. |journal=Blood |volume=87 |issue= 4 |pages= 1211-24 |year= 1996 |pmid= 8608207 |doi=  }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y | title = Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock | journal = Biochemical and Biophysical Research Communications | volume = 248 | issue = 3 | pages = 789–94 | date = July 1998 | pmid = 9704006 | doi = 10.1006/bbrc.1998.9012 }}
*{{cite journal | author=Hunger SP, Li S, Fall MZ, ''et al.'' |title=The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. |journal=Blood |volume=87 |issue= 11 |pages= 4607-17 |year= 1996 |pmid= 8639829 |doi=  }}
* {{cite journal | vauthors = Inukai T, Inaba T, Ikushima S, Look AT | title = The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF | journal = Molecular and Cellular Biology | volume = 18 | issue = 10 | pages = 6035–43 | date = October 1998 | pmid = 9742120 | pmc = 109189 | doi =  }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
* {{cite journal | vauthors = Begbie M, Mueller C, Lillicrap D | title = Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes | journal = DNA and Cell Biology | volume = 18 | issue = 2 | pages = 165–73 | date = February 1999 | pmid = 10073576 | doi = 10.1089/104454999315556 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y | title = Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 | journal = The EMBO Journal | volume = 18 | issue = 7 | pages = 1905–14 | date = April 1999 | pmid = 10202154 | pmc = 1171276 | doi = 10.1093/emboj/18.7.1905 }}
*{{cite journal | author=Takahata S, Sogawa K, Kobayashi A, ''et al.'' |title=Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 3 |pages= 789-94 |year= 1998 |pmid= 9704006 |doi= 10.1006/bbrc.1998.9012 }}
* {{cite journal | vauthors = Honda H, Inaba T, Suzuki T, Oda H, Ebihara Y, Tsuiji K, Nakahata T, Ishikawa T, Yazaki Y, Hirai H | title = Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia | journal = Blood | volume = 93 | issue = 9 | pages = 2780–90 | date = May 1999 | pmid = 10216071 | doi =  }}
*{{cite journal | author=Inukai T, Inaba T, Ikushima S, Look AT |title=The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 6035-43 |year= 1998 |pmid= 9742120 |doi=  }}
* {{cite journal | vauthors = Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, Funabiki T, Endo M, Look AT, Kurosawa H | title = Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein | journal = Blood | volume = 103 | issue = 8 | pages = 3185–91 | date = April 2004 | pmid = 15070701 | doi = 10.1182/blood-2003-09-3022 }}
*{{cite journal | author=Begbie M, Mueller C, Lillicrap D |title=Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes. |journal=DNA Cell Biol. |volume=18 |issue= 2 |pages= 165-73 |year= 1999 |pmid= 10073576 |doi= 10.1089/104454999315556 }}
*{{cite journal | author=Ema M, Hirota K, Mimura J, ''et al.'' |title=Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1905-14 |year= 1999 |pmid= 10202154 |doi= 10.1093/emboj/18.7.1905 }}
*{{cite journal | author=Honda H, Inaba T, Suzuki T, ''et al.'' |title=Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia. |journal=Blood |volume=93 |issue= 9 |pages= 2780-90 |year= 1999 |pmid= 10216071 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Matsunaga T, Inaba T, Matsui H, ''et al.'' |title=Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. |journal=Blood |volume=103 |issue= 8 |pages= 3185-91 |year= 2004 |pmid= 15070701 |doi= 10.1182/blood-2003-09-3022 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|HLF+protein,+human}}
* {{MeshName|HLF+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-17-stub}}

Latest revision as of 13:52, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2]

Function

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]

References

  1. ↑ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. doi:10.1126/science.1386162. PMID 1386162.
  2. ↑ 2.0 2.1 "Entrez Gene: HLF hepatic leukemia factor".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=HLF_(gene)&oldid=1417821"