ZNF74: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 74''' is a [[protein]] that in humans is encoded by the ''ZNF74'' [[gene]].<ref name="pmid1639391">{{cite journal | vauthors = Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA | title = Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2) | journal = Genomics | volume = 13 | issue = 3 | pages = 641–8 | date = August 1992 | pmid = 1639391 | pmc =  | doi = 10.1016/0888-7543(92)90135-F }}</ref><ref name="pmid10591208">{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = December 1999 | pmid = 10591208 | pmc =  | doi = 10.1038/990031 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF74 zinc finger protein 74| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7625| accessdate = }}</ref> Schizophrenia susceptibility has been associated with a mutation in this protein.<ref name=schizophrenia>{{cite journal|last=Takase|first=K.|author2=T. Ohtsuki |author3=O. Migita |author4=M. Toru |author5=T. Inada |author6=K. Yamakawa-Kobayashi |author7=T. Arinami |title=Association of ZNF74 gene genotypes with age-at-onset of schizophrenia|date=1 December 2001|volume=52|issue=3|pages=161–165|accessdate=4 July 2012}}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Zinc finger protein 74
| HGNCid = 13144
| Symbol = ZNF74
| AltSymbols =; Cos52; ZNF520; Zfp520
| OMIM = 194548
| ECnumber = 
| Homologene = 88675
| MGIid = 
| GeneAtlas_image1 = PBB_GE_ZNF74_205881_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7625
    | Hs_Ensembl = ENSG00000185252
    | Hs_RefseqProtein = NP_003417
    | Hs_RefseqmRNA = NM_003426
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 19078807
    | Hs_GenLoc_end = 19091967
    | Hs_Uniprot = Q16587
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Zinc finger protein 74''', also known as '''ZNF74''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNF74 zinc finger protein 74| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7625| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
ZNF74 has been shown to [[Protein-protein interaction|interact]] with [[POLR2A]].<ref name=pmid9346935>{{cite journal | vauthors = Grondin B, Côté F, Bazinet M, Vincent M, Aubry M | title = Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27877–85 | date = October 1997 | pmid = 9346935 | doi = 10.1074/jbc.272.44.27877 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Aubry M, Demczuk S, Desmaze C, Aikem M, Aurias A, Julien JP, Rouleau GA | title = Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome | journal = Hum. Mol. Genet. | volume = 2 | issue = 10 | pages = 1583–7 | year = 1994 | pmid = 8268910 | doi = 10.1093/hmg/2.10.1583 }}
| citations =
* {{cite journal | vauthors = Grondin B, Bazinet M, Aubry M | title = The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix | journal = J. Biol. Chem. | volume = 271 | issue = 26 | pages = 15458–67 | year = 1996 | pmid = 8663113 | doi = 10.1074/jbc.271.26.15458 }}
*{{cite journal | author=Aubry M, Marineau C, Zhang FR, ''et al.'' |title=Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). |journal=Genomics |volume=13 |issue= 3 |pages= 641-8 |year= 1992 |pmid= 1639391 |doi=  }}
* {{cite journal | vauthors = Grondin B, Côté F, Bazinet M, Vincent M, Aubry M | title = Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27877–85 | year = 1997 | pmid = 9346935 | doi = 10.1074/jbc.272.44.27877 }}
*{{cite journal  | author=Aubry M, Demczuk S, Desmaze C, ''et al.'' |title=Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1583-7 |year= 1994 |pmid= 8268910 |doi= }}
* {{cite journal | vauthors = Ravassard P, Côté F, Grondin B, Bazinet M, Mallet J, Aubry M | title = ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia | journal = Genomics | volume = 62 | issue = 1 | pages = 82–5 | year = 2000 | pmid = 10585771 | doi = 10.1006/geno.1999.5982 }}
*{{cite journal | author=Grondin B, Bazinet M, Aubry M |title=The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix. |journal=J. Biol. Chem. |volume=271 |issue= 26 |pages= 15458-67 |year= 1996 |pmid= 8663113 |doi= }}
* {{cite journal | vauthors = Côté F, Boisvert FM, Grondin B, Bazinet M, Goodyer CG, Bazett-Jones DP, Aubry M | title = Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning | journal = DNA Cell Biol. | volume = 20 | issue = 3 | pages = 159–73 | year = 2001 | pmid = 11313019 | doi = 10.1089/104454901300069004 }}
*{{cite journal | author=Grondin B, Côté F, Bazinet M, ''et al.'' |title=Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27877-85 |year= 1997 |pmid= 9346935 |doi= }}
* {{cite journal | vauthors = Takase K, Ohtsuki T, Migita O, Toru M, Inada T, Yamakawa-Kobayashi K, Arinami T | title = Association of ZNF74 gene genotypes with age-at-onset of schizophrenia | journal = [[Schizophrenia Research]] | volume = 52 | issue = 3 | pages = 161–5 | year = 2001 | pmid = 11705709 | doi = 10.1016/S0920-9964(00)00191-2 }}
*{{cite journal | author=Ravassard P, Côté F, Grondin B, ''et al.'' |title=ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia. |journal=Genomics |volume=62 |issue= 1 |pages= 82-5 |year= 2000 |pmid= 10585771 |doi= 10.1006/geno.1999.5982 }}
* {{cite journal | vauthors = Germain-Desprez D, Bazinet M, Bouvier M, Aubry M | title = Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22367–73 | year = 2003 | pmid = 12684500 | doi = 10.1074/jbc.M302234200 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | author=Côté F, Boisvert FM, Grondin B, ''et al.'' |title=Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning. |journal=DNA Cell Biol. |volume=20 |issue= 3 |pages= 159-73 |year= 2001 |pmid= 11313019 |doi= 10.1089/104454901300069004 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Takase K, Ohtsuki T, Migita O, ''et al.'' |title=Association of ZNF74 gene genotypes with age-at-onset of schizophrenia. |journal=[[Schizophrenia Research]] |volume=52 |issue= 3 |pages= 161-5 |year= 2001 |pmid= 11705709 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Germain-Desprez D, Bazinet M, Bouvier M, Aubry M |title=Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22367-73 |year= 2003 |pmid= 12684500 |doi= 10.1074/jbc.M302234200 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ZNF74+protein,+human}}
* {{MeshName|ZNF74+protein,+human}}
{{Transcription factors|g2}}
{{NLM content}}
[[Category:Transcription factors]]




{{gene-22-stub}}
{{gene-22-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 01:14, 19 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[1][2][3] Schizophrenia susceptibility has been associated with a mutation in this protein.[4]

Interactions

ZNF74 has been shown to interact with POLR2A.[5]

References

  1. ↑ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics. 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391.
  2. ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  3. ↑ "Entrez Gene: ZNF74 zinc finger protein 74".
  4. ↑ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia". 52 (3): 161–165. |access-date= requires |url= (help)
  5. ↑ Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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