ZBTB7A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger and BTB domain-containing protein 7A''' is a [[protein]] that in humans is encoded by the ''ZBTB7A'' [[gene]].<ref name="pmid9973611">{{cite journal | vauthors = Morrison DJ, Pendergrast PS, Stavropoulos P, Colmenares SU, Kobayashi R, Hernandez N | title = FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein | journal = Nucleic Acids Res | volume = 27 | issue = 5 | pages = 1251–62 |date=Apr 1999 | pmid = 9973611 | pmc = 148309 | doi =10.1093/nar/27.5.1251  }}</ref><ref name="pmid9927193">{{cite journal | vauthors = Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A | title = Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene | journal = Oncogene | volume = 18 | issue = 2 | pages = 365–75 |date=Feb 1999 | pmid = 9927193 | pmc =  | doi = 10.1038/sj.onc.1202332 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51341| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{GNF_Protein_box
ZBTB7A has been shown to [[Protein-protein interaction|interact]] with [[BCL6]].<ref name=autogenerated1>{{cite journal | vauthors = Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A | title = Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene | journal = Oncogene | volume = 18 | issue = 2 | pages = 365–75 |date=January 1999 | pmid = 9927193 | doi = 10.1038/sj.onc.1202332  }}</ref>
| image = PBB_Protein_ZBTB7A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2if5.
| PDB = {{PDB2|2if5}}, {{PDB2|2nn2}}
| Name = Zinc finger and BTB domain containing 7A
| HGNCid = 18078
| Symbol = ZBTB7A
| AltSymbols =; DKFZp547O146; FBI-1; FBI1; LRF; MGC99631; ZBTB7; pokemon
| OMIM = 605878
| ECnumber = 
| Homologene = 7820
| MGIid = 1335091
| GeneAtlas_image1 = PBB_GE_ZBTB7A_213299_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZBTB7A_213303_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ZBTB7A_219186_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0035035 |text = histone acetyltransferase binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0051216 |text = cartilage development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51341
    | Hs_Ensembl = ENSG00000178951
    | Hs_RefseqProtein = NP_056982
    | Hs_RefseqmRNA = NM_015898
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 3996217
    | Hs_GenLoc_end = 4017816
    | Hs_Uniprot = O95365
    | Mm_EntrezGene = 16969
    | Mm_Ensembl = ENSMUSG00000035011
    | Mm_RefseqmRNA = NM_010731
    | Mm_RefseqProtein = NP_034861
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80547087
    | Mm_GenLoc_end = 80551582
    | Mm_Uniprot = Q3U372
  }}
}}
'''Zinc finger and BTB domain containing 7A''', also known as '''ZBTB7A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51341| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==See also==
{{PBB_Summary
* ''[[Zbtb7]]''
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
| citations =
*{{cite journal  | vauthors=Pendergrast PS, Wang C, Hernandez N, Huang S |title=FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles |journal=Mol. Biol. Cell |volume=13 |issue= 3 |pages= 915–29 |year= 2002 |pmid= 11907272 |doi= 10.1091/mbc.01-08-0383 | pmc=99609 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Lee DK, Suh D, Edenberg HJ, Hur MW |title=POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1 |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26761–8 |year= 2002 |pmid= 12004059 |doi= 10.1074/jbc.M202078200 }}
*{{cite journal  | author=Davies JM, Hawe N, Kabarowski J, ''et al.'' |title=Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. |journal=Oncogene |volume=18 |issue= 2 |pages= 365-75 |year= 1999 |pmid= 9927193 |doi= 10.1038/sj.onc.1202332 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Morrison DJ, Pendergrast PS, Stavropoulos P, ''et al.'' |title=FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. |journal=Nucleic Acids Res. |volume=27 |issue= 5 |pages= 1251-62 |year= 1999 |pmid= 9973611 |doi= }}
*{{cite journal  | vauthors=Pessler F, Hernandez N |title=Flexible DNA binding of the BTB/POZ-domain protein FBI-1 |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29327–35 |year= 2003 |pmid= 12750370 |doi= 10.1074/jbc.M302980200 }}
*{{cite journal  | author=Pendergrast PS, Wang C, Hernandez N, Huang S |title=FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles. |journal=Mol. Biol. Cell |volume=13 |issue= 3 |pages= 915-29 |year= 2002 |pmid= 11907272 |doi= 10.1091/mbc.01-08-0383 }}
*{{cite journal   |vauthors=Laudes M, Christodoulides C, Sewter C, etal |title=Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11711–8 |year= 2004 |pmid= 14701838 |doi= 10.1074/jbc.M310240200 }}
*{{cite journal  | author=Lee DK, Suh D, Edenberg HJ, Hur MW |title=POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26761-8 |year= 2002 |pmid= 12004059 |doi= 10.1074/jbc.M202078200 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Liu CJ, Prazak L, Fajardo M, etal |title=Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47081–91 |year= 2004 |pmid= 15337766 |doi= 10.1074/jbc.M405288200 }}
*{{cite journal  | author=Pessler F, Hernandez N |title=Flexible DNA binding of the BTB/POZ-domain protein FBI-1. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29327-35 |year= 2003 |pmid= 12750370 |doi= 10.1074/jbc.M302980200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Laudes M, Christodoulides C, Sewter C, ''et al.'' |title=Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11711-8 |year= 2004 |pmid= 14701838 |doi= 10.1074/jbc.M310240200 }}
*{{cite journal   |vauthors=Maeda T, Hobbs RM, Merghoub T, etal |title=Role of the proto-oncogene Pokémon in cellular transformation and ARF repression |journal=Nature |volume=433 |issue= 7023 |pages= 278–85 |year= 2005 |pmid= 15662416 |doi= 10.1038/nature03203 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Lee DK, Kang JE, Park HJ, etal |title=FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27783–91 |year= 2005 |pmid= 15917220 |doi= 10.1074/jbc.M504909200 }}
*{{cite journal | author=Liu CJ, Prazak L, Fajardo M, ''et al.'' |title=Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47081-91 |year= 2004 |pmid= 15337766 |doi= 10.1074/jbc.M405288200 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Roh HE, Lee MN, Jeon BN, etal |title=Regulation of Pokémon 1 activity by sumoylation |journal=Cell. Physiol. Biochem. |volume=20 |issue= 1–4 |pages= 167–80 |year= 2007 |pmid= 17595526 |doi= 10.1159/000104164 }}
*{{cite journal | author=Maeda T, Hobbs RM, Merghoub T, ''et al.'' |title=Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. |journal=Nature |volume=433 |issue= 7023 |pages= 278-85 |year= 2005 |pmid= 15662416 |doi= 10.1038/nature03203 }}
*{{cite journal | author=Lee DK, Kang JE, Park HJ, ''et al.'' |title=FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB. |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27783-91 |year= 2005 |pmid= 15917220 |doi= 10.1074/jbc.M504909200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Roh HE, Lee MN, Jeon BN, ''et al.'' |title=Regulation of pokemon 1 activity by sumoylation. |journal=Cell. Physiol. Biochem. |volume=20 |issue= 1-4 |pages= 167-80 |year= 2007 |pmid= 17595526 |doi= 10.1159/000104164 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ZBTB7A+protein,+human}}
* {{MeshName|ZBTB7A+protein,+human}}
* {{FactorBook|ZBTB7A}}
{{PDB Gallery|geneid=51341}}
{{Transcription factors|g2}}
{{NLM content}}
{{DEFAULTSORT:Zbtb7a}}
[[Category:Transcription factors]]




{{gene-19-stub}}
{{gene-19-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 01:04, 19 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.[1][2][3]

Interactions

ZBTB7A has been shown to interact with BCL6.[4]

See also

References

  1. ↑ Morrison DJ, Pendergrast PS, Stavropoulos P, Colmenares SU, Kobayashi R, Hernandez N (Apr 1999). "FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein". Nucleic Acids Res. 27 (5): 1251–62. doi:10.1093/nar/27.5.1251. PMC 148309. PMID 9973611.
  2. ↑ Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Feb 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193.
  3. ↑ "Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A".
  4. ↑ Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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