TFCP2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Alpha-globin transcription factor CP2''' is a [[protein]] that in humans is encoded by the ''TFCP2'' [[gene]].<ref name="pmid8157699">{{cite journal | vauthors = Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M | title = Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 15 | pages = 11663–71 | date = Apr 1994 | pmid = 8157699 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TFCP2 transcription factor CP2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7024| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
TFCP2 is also called '''Late SV40 factor''' ('''LSF''') and it is induced by well known oncogene [[MTDH|AEG-1]].<ref name="pmid19622726">{{cite journal | vauthors = Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D | title = Identification of genes conferring resistance to 5-fluorouracil | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 31 | pages = 12938–43 | date = Aug 2009 | pmid = 19622726 | pmc = 2722317 | doi = 10.1073/pnas.0901451106 }}</ref> Late SV40 factor (LSF) also acts as an oncogene in [[hepatocellular carcinoma]].<ref name="pmid20404171">{{cite journal | vauthors = Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D | title = Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 107 | issue = 18 | pages = 8357–62 | date = May 2010 | pmid = 20404171 | pmc = 2889542 | doi = 10.1073/pnas.1000374107 }}</ref> Late SV40 factor (LSF) enhances [[angiogenesis]] by transcriptionally up-regulating matrix metalloproteinase-9 ([[MMP9]]).<ref name="pmid22167195">{{cite journal | vauthors = Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D | title = Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9) | journal = The Journal of Biological Chemistry | volume = 287 | issue = 5 | pages = 3425–32 | date = Jan 2012 | pmid = 22167195 | pmc = 3270996 | doi = 10.1074/jbc.M111.298976 }}</ref>
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Transcription factor CP2
| HGNCid = 11748
| Symbol = TFCP2
| AltSymbols =; CP2; LBP-1C; LSF; SEF; TFCP2C
| OMIM = 189889
| ECnumber =
| Homologene = 4134
| MGIid = 98509
| GeneAtlas_image1 = PBB_GE_TFCP2_207627_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TFCP2_209338_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}  
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7024
    | Hs_Ensembl = ENSG00000135457
    | Hs_RefseqProtein = NP_005644
    | Hs_RefseqmRNA = NM_005653
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 49774891
    | Hs_GenLoc_end = 49852931
    | Hs_Uniprot = Q12800
    | Mm_EntrezGene = 21422
    | Mm_Ensembl = ENSMUSG00000009733
    | Mm_RefseqmRNA = NM_033476
    | Mm_RefseqProtein = NP_258437
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 100330830
    | Mm_GenLoc_end = 100380015
    | Mm_Uniprot = Q3URS4
  }}
}}
'''Transcription factor CP2''', also known as '''TFCP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TFCP2 transcription factor CP2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7024| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Along with its main [[oncogene]] function in [[hepatocellular carcinoma]] (HCC) it plays multifaceted role in chemoresistance, [[epithelial-mesenchymal transition]] (EMT), allergic response, inflammation and [[Alzheimer's disease]].<ref name="pmid20404171"/><ref name=Santhekadur>{{cite journal | vauthors = Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D | year = 2012 | title = The transcription factor LSF: a novel oncogene for hepatocellular carcinoma | journal = Am J Cancer Res | volume = 2 | issue = 3 | pages = 269–285 | url = http://www.ajcr.us/files/ajcr0000110.pdf}}</ref> The [[small molecule]] FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.<ref name="pmid20404171"/><ref name=Santhekadur/><ref name="pmid22396589">{{cite journal | vauthors = Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U | title = Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 12 | pages = 4503–8 | date = Mar 2012 | pmid = 22396589 | pmc = 3311344 | doi = 10.1073/pnas.1121601109 | laysummary = http://208.43.66.241/new_compound_discovered_that_rapidly_kills_liver_cancer-87786 | laysource = Science Codex }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TFCP2 has been shown to [[Protein-protein interaction|interact]] with [[APBB1]]<ref name="pmid9685356">{{cite journal | vauthors = Zambrano N, Minopoli G, de Candia P, Russo T | title = The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 32 | pages = 20128–33 | date = Aug 1998 | pmid = 9685356 | doi = 10.1074/jbc.273.32.20128 }}</ref> and [[RNF2]].<ref name="pmid11865070">{{cite journal | vauthors = Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM | title = Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors | journal = Molecular and Cellular Biology | volume = 22 | issue = 6 | pages = 1936–46 | date = Mar 2002 | pmid = 11865070 | pmc = 135618 | doi = 10.1128/MCB.22.6.1936-1946.2002 }}</ref>
 
== References ==
{{reflist | 2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lim LC, Swendeman SL, Sheffery M | title = Molecular cloning of the alpha-globin transcription factor CP2 | journal = Molecular and Cellular Biology | volume = 12 | issue = 2 | pages = 828–35 | date = Feb 1992 | pmid = 1732747 | pmc = 364316 | doi =  10.1128/mcb.12.2.828}}
| citations =
* {{cite journal | vauthors = Jane SM, Nienhuis AW, Cunningham JM | title = Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein | journal = The EMBO Journal | volume = 14 | issue = 1 | pages = 97–105 | date = Jan 1995 | pmid = 7828600 | pmc = 398056 | doi =  }}
*{{cite journal | author=Lim LC, Swendeman SL, Sheffery M |title=Molecular cloning of the alpha-globin transcription factor CP2. |journal=Mol. Cell. Biol. |volume=12 |issue= 2 |pages= 828-35 |year= 1992 |pmid= 1732747 |doi=  }}
* {{cite journal | vauthors = Shirra MK, Zhu Q, Huang HC, Pallas D, Hansen U | title = One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs | journal = Molecular and Cellular Biology | volume = 14 | issue = 8 | pages = 5076–87 | date = Aug 1994 | pmid = 8035790 | pmc = 359026 | doi =  10.1128/mcb.14.8.5076}}
*{{cite journal | author=Jane SM, Nienhuis AW, Cunningham JM |title=Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. |journal=EMBO J. |volume=14 |issue= 1 |pages= 97-105 |year= 1995 |pmid= 7828600 |doi=  }}
* {{cite journal | vauthors = Yoon JB, Li G, Roeder RG | title = Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro | journal = Molecular and Cellular Biology | volume = 14 | issue = 3 | pages = 1776–85 | date = Mar 1994 | pmid = 8114710 | pmc = 358535 | doi =  10.1128/mcb.14.3.1776}}
*{{cite journal | author=Shirra MK, Zhu Q, Huang HC, ''et al.'' |title=One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. |journal=Mol. Cell. Biol. |volume=14 |issue= 8 |pages= 5076-87 |year= 1994 |pmid= 8035790 |doi=  }}
* {{cite journal | vauthors = Margolis DM, Somasundaran M, Green MR | title = Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production | journal = Journal of Virology | volume = 68 | issue = 2 | pages = 905–10 | date = Feb 1994 | pmid = 8289393 | pmc = 236527 | doi =  }}
*{{cite journal | author=Yoon JB, Li G, Roeder RG |title=Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 1776-85 |year= 1994 |pmid= 8114710 |doi=  }}
* {{cite journal | vauthors = Cunningham JM, Vanin EF, Tran N, Valentine M, Jane SM | title = The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene | journal = Genomics | volume = 30 | issue = 2 | pages = 398–9 | date = Nov 1995 | pmid = 8586452 | doi =  }}
*{{cite journal | author=Swendeman SL, Spielholz C, Jenkins NA, ''et al.'' |title=Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11663-71 |year= 1994 |pmid= 8157699 |doi=  }}
* {{cite journal | vauthors = Romerio F, Gabriel MN, Margolis DM | title = Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF | journal = Journal of Virology | volume = 71 | issue = 12 | pages = 9375–82 | date = Dec 1997 | pmid = 9371597 | pmc = 230241 | doi =  }}
*{{cite journal | author=Margolis DM, Somasundaran M, Green MR |title=Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production. |journal=J. Virol. |volume=68 |issue= 2 |pages= 905-10 |year= 1994 |pmid= 8289393 |doi=  }}
* {{cite journal | vauthors = Zambrano N, Minopoli G, de Candia P, Russo T | title = The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 32 | pages = 20128–33 | date = Aug 1998 | pmid = 9685356 | doi = 10.1074/jbc.273.32.20128 }}
*{{cite journal | author=Cunningham JM, Vanin EF, Tran N, ''et al.'' |title=The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene. |journal=Genomics |volume=30 |issue= 2 |pages= 398-9 |year= 1996 |pmid= 8586452 |doi=  }}
* {{cite journal | vauthors = Bing Z, Reddy SA, Ren Y, Qin J, Liao WS | title = Purification and characterization of the serum amyloid A3 enhancer factor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 35 | pages = 24649–56 | date = Aug 1999 | pmid = 10455131 | doi = 10.1074/jbc.274.35.24649 }}
*{{cite journal | author=Romerio F, Gabriel MN, Margolis DM |title=Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF. |journal=J. Virol. |volume=71 |issue= 12 |pages= 9375-82 |year= 1997 |pmid= 9371597 |doi= }}
* {{cite journal | vauthors = Coull JJ, Romerio F, Sun JM, Volker JL, Galvin KM, Davie JR, Shi Y, Hansen U, Margolis DM | title = The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1 | journal = Journal of Virology | volume = 74 | issue = 15 | pages = 6790–9 | date = Aug 2000 | pmid = 10888618 | pmc = 112196 | doi = 10.1128/JVI.74.15.6790-6799.2000 }}
*{{cite journal | author=Zambrano N, Minopoli G, de Candia P, Russo T |title=The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20128-33 |year= 1998 |pmid= 9685356 |doi= }}
* {{cite journal | vauthors = Zhou W, Clouston DR, Wang X, Cerruti L, Cunningham JM, Jane SM | title = Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4 | journal = Molecular and Cellular Biology | volume = 20 | issue = 20 | pages = 7662–72 | date = Oct 2000 | pmid = 11003662 | pmc = 86334 | doi = 10.1128/MCB.20.20.7662-7672.2000 }}
*{{cite journal | author=Bing Z, Reddy SA, Ren Y, ''et al.'' |title=Purification and characterization of the serum amyloid A3 enhancer factor. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24649-56 |year= 1999 |pmid= 10455131 |doi= }}
* {{cite journal | vauthors = Rodda S, Sharma S, Scherer M, Chapman G, Rathjen P | title = CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors | journal = The Journal of Biological Chemistry | volume = 276 | issue = 5 | pages = 3324–32 | date = Feb 2001 | pmid = 11073954 | doi = 10.1074/jbc.M008167200 }}
*{{cite journal | author=Coull JJ, Romerio F, Sun JM, ''et al.'' |title=The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. |journal=J. Virol. |volume=74 |issue= 15 |pages= 6790-9 |year= 2000 |pmid= 10888618 |doi= }}
* {{cite journal | vauthors = Zheng JB, Zhou YH, Maity T, Liao WS, Saunders GF | title = Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1 | journal = Nucleic Acids Research | volume = 29 | issue = 19 | pages = 4070–8 | date = Oct 2001 | pmid = 11574690 | pmc = 60230 | doi = 10.1093/nar/29.2.e6 }}
*{{cite journal | author=Zhou W, Clouston DR, Wang X, ''et al.'' |title=Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7662-72 |year= 2000 |pmid= 11003662 |doi= }}
* {{cite journal | vauthors = Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM | title = Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors | journal = Molecular and Cellular Biology | volume = 22 | issue = 6 | pages = 1936–46 | date = Mar 2002 | pmid = 11865070 | pmc = 135618 | doi = 10.1128/MCB.22.6.1936-1946.2002 }}
*{{cite journal | author=Rodda S, Sharma S, Scherer M, ''et al.'' |title=CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3324-32 |year= 2001 |pmid= 11073954 |doi= 10.1074/jbc.M008167200 }}
* {{cite journal | vauthors = He G, Margolis DM | title = Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 2965–73 | date = May 2002 | pmid = 11940654 | pmc = 133763 | doi = 10.1128/MCB.22.9.2965-2973.2002 }}
*{{cite journal | author=Zheng JB, Zhou YH, Maity T, ''et al.'' |title=Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1. |journal=Nucleic Acids Res. |volume=29 |issue= 19 |pages= 4070-8 |year= 2001 |pmid= 11574690 |doi= }}
* {{cite journal | vauthors = Peters LM, Anderson DW, Griffith AJ, Grundfast KM, San Agustin TB, Madeo AC, Friedman TB, Morell RJ | title = Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28 | journal = Human Molecular Genetics | volume = 11 | issue = 23 | pages = 2877–85 | date = Nov 2002 | pmid = 12393799 | doi = 10.1093/hmg/11.23.2877 }}
*{{cite journal | author=Tuckfield A, Clouston DR, Wilanowski TM, ''et al.'' |title=Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1936-46 |year= 2002 |pmid= 11865070 |doi= }}
* {{cite journal | vauthors = Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI | title = Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease | journal = American Journal of Medical Genetics Part B | volume = 117B | issue = 1 | pages = 114–7 | date = Feb 2003 | pmid = 12555245 | doi = 10.1002/ajmg.b.10026 }}
*{{cite journal | author=He G, Margolis DM |title=Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 2965-73 |year= 2002 |pmid= 11940654 |doi= }}
* {{cite journal | vauthors = Chae JH, Kim CG | title = CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells | journal = Molecules and Cells | volume = 15 | issue = 1 | pages = 40–7 | date = Feb 2003 | pmid = 12661759 | doi =  }}
*{{cite journal | author=Peters LM, Anderson DW, Griffith AJ, ''et al.'' |title=Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28. |journal=Hum. Mol. Genet. |volume=11 |issue= 23 |pages= 2877-85 |year= 2003 |pmid= 12393799 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI |title=Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=117 |issue= 1 |pages= 114-7 |year= 2003 |pmid= 12555245 |doi= 10.1002/ajmg.b.10026 }}
*{{cite journal  | author=Chae JH, Kim CG |title=CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells. |journal=Mol. Cells |volume=15 |issue= 1 |pages= 40-7 |year= 2003 |pmid= 12661759 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Transcription factors|g4}}
{{WikiDoc Sources}}
 
[[Category:Transcription factors]]

Latest revision as of 11:47, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[1][2]

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1.[3] Late SV40 factor (LSF) also acts as an oncogene in hepatocellular carcinoma.[4] Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[5]

Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[4][6] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.[4][6][7]

Interactions

TFCP2 has been shown to interact with APBB1[8] and RNF2.[9]

References

  1. ↑ Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. PMID 8157699.
  2. ↑ "Entrez Gene: TFCP2 transcription factor CP2".
  3. ↑ Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. doi:10.1073/pnas.0901451106. PMC 2722317. PMID 19622726.
  4. ↑ 4.0 4.1 4.2 Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. doi:10.1073/pnas.1000374107. PMC 2889542. PMID 20404171.
  5. ↑ Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi:10.1074/jbc.M111.298976. PMC 3270996. PMID 22167195.
  6. ↑ 6.0 6.1 Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285.
  7. ↑ Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. doi:10.1073/pnas.1121601109. PMC 3311344. PMID 22396589. Lay summary – Science Codex.
  8. ↑ Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi:10.1074/jbc.273.32.20128. PMID 9685356.
  9. ↑ Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=TFCP2&oldid=1415730"