SOX13

SRY (sex determining region Y)-box 13
File:PBB Protein SOX13 image.jpg PDB rendering based on 1i11.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1i11​
Identifiers
Symbols	SOX13 ; ICA12; MGC117216; SRY-box 13; Sox-13
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4159
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SRY (sex determining region Y)-box 13, also known as SOX13, is a human gene.

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.

See also

• SOX genes

Further reading

• Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. PMID 12100890.
• Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell. 3 (2): 167–70. PMID 12194848.CS1 maint: Multiple names: authors list (link)
• Roose J, Korver W, Oving E; et al. (1998). "High expression of the HMG box factor sox-13 in arterial walls during embryonic development". Nucleic Acids Res. 26 (2): 469–76. PMID 9421502.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roose J, Korver W, de Boer R; et al. (1999). "The Sox-13 gene: structure, promoter characterization, and chromosomal localization". Genomics. 57 (2): 301–5. doi:10.1006/geno.1999.5779. PMID 10198172.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Argentaro A, Olsson J, Critcher R; et al. (2000). "Genomic characterisation and fine mapping of the human SOX13 gene". Gene. 250 (1–2): 181–9. PMID 10854791.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kasimiotis H, Myers MA, Argentaro A; et al. (2000). "Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets". Diabetes. 49 (4): 555–61. PMID 10871192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steinbrenner H, Lohmann T, Ostendorf B; et al. (2001). "Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes". Diabetologia. 43 (11): 1381–4. PMID 11126406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kasimiotis H, Fida S, Rowley MJ; et al. (2001). "Antibodies to SOX13 (ICA12) are associated with type 1 diabetes". Autoimmunity. 33 (2): 95–101. PMID 11264788.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lampasona V, Scirpoli M, Bosi E, Bonifacio E (2001). "ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes". Diabetologia. 44 (2): 267. PMID 11270687.CS1 maint: Multiple names: authors list (link)
• Argentaro A, Wapelhorst B, Concannon P, Harley VR (2001). "Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes". Mol. Genet. Metab. 72 (4): 356–9. doi:10.1006/mgme.2000.3136. PMID 11286511.CS1 maint: Multiple names: authors list (link)
• Fida S, Myers M, Mackay IR; et al. (2001). "Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13". Diabetes Res. Clin. Pract. 52 (3): 205–11. PMID 11323090.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tandon N, Shtauvere-Brameus A, Hagopian WA, Sanjeevi CB (2002). "Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes". Ann. N. Y. Acad. Sci. 958: 214–7. PMID 12021109.CS1 maint: Multiple names: authors list (link)
• Törn C, Shtauvere-Brameus A, Sanjeevi CB, Landin-Olsson M (2002). "Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes". Ann. N. Y. Acad. Sci. 958: 218–23. PMID 12021110.CS1 maint: Multiple names: authors list (link)
• Shtauvere-Brameus A, Hagopian W, Rumba I, Sanjeevi CB (2002). "Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients". Ann. N. Y. Acad. Sci. 958: 297–304. PMID 12021128.CS1 maint: Multiple names: authors list (link)
• Gupta M, Tandon N, Shtauvere-Brameus A, Sanjeevi CB (2002). "ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India". Ann. N. Y. Acad. Sci. 958: 329–32. PMID 12021135.CS1 maint: Multiple names: authors list (link)
• Fida S, Myers MA, Whittingham S; et al. (2003). "Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases". J. Autoimmun. 19 (4): 251–7. PMID 12473246.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park Y, Park H, Yoo E, Kim D (2004). "SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea". Ann. N. Y. Acad. Sci. 1005: 253–8. PMID 14679071.CS1 maint: Multiple names: authors list (link)

External links

• SOX13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.