SIX5: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein SIX5''' is a [[protein]] that in humans is encoded by the ''SIX5'' [[gene]].<ref name="pmid8595416">{{cite journal | vauthors = Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL | title = A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat | journal = Hum Mol Genet | volume = 4 | issue = 10 | pages = 1919–25 | date = Apr 1996 | pmid = 8595416 | pmc =  | doi = 10.1093/hmg/4.10.1919 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147912| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Sine oculis homeobox homolog 5 (Drosophila)
| HGNCid = 10891
| Symbol = SIX5
| AltSymbols =; DMAHP
| OMIM = 600963
| ECnumber = 
| Homologene = 72248
| MGIid = 106220
| GeneAtlas_image1 = PBB_GE_SIX5_217661_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 147912
    | Hs_Ensembl = ENSG00000177045
    | Hs_RefseqProtein = NP_787071
    | Hs_RefseqmRNA = NM_175875
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 50959884
    | Hs_GenLoc_end = 50964152
    | Hs_Uniprot = Q8N196
    | Mm_EntrezGene = 20475
    | Mm_Ensembl = ENSMUSG00000040841
    | Mm_RefseqmRNA = NM_011383
    | Mm_RefseqProtein = NP_035513
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 18253066
    | Mm_GenLoc_end = 18256867
    | Mm_Uniprot = P70178
  }}
}}
'''Sine oculis homeobox homolog 5 (Drosophila)''', also known as '''SIX5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147912| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Murakami Y, Ohto H, Ikeda U, Shimada K, Momoi T, Kawakami K | title = Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements | journal = Hum. Mol. Genet. | volume = 7 | issue = 13 | pages = 2103–12 | year = 1999 | pmid = 9817928 | doi = 10.1093/hmg/7.13.2103 }}
| citations =
* {{cite journal | vauthors = Winchester CL, Ferrier RK, Sermoni A, Clark BJ, Johnson KJ | title = Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy | journal = Hum. Mol. Genet. | volume = 8 | issue = 3 | pages = 481–92 | year = 1999 | pmid = 9949207 | doi = 10.1093/hmg/8.3.481 }}
*{{cite journal  | author=Boucher CA, King SK, Carey N, ''et al.'' |title=A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. |journal=Hum. Mol. Genet. |volume=4 |issue= 10 |pages= 1919-25 |year= 1996 |pmid= 8595416 |doi=  }}
* {{cite journal | vauthors = Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K | title = Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya | journal = Mol. Cell. Biol. | volume = 19 | issue = 10 | pages = 6815–24 | year = 2000 | pmid = 10490620 | pmc = 84678 | doi =  10.1128/mcb.19.10.6815}}
*{{cite journal | author=Murakami Y, Ohto H, Ikeda U, ''et al.'' |title=Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements. |journal=Hum. Mol. Genet. |volume=7 |issue= 13 |pages= 2103-12 |year= 1999 |pmid= 9817928 |doi= }}
* {{cite journal | vauthors = Harris SE, Winchester CL, Johnson KJ | title = Functional analysis of the homeodomain protein SIX5 | journal = Nucleic Acids Res. | volume = 28 | issue = 9 | pages = 1871–8 | year = 2000 | pmid = 10756185 | pmc = 103302 | doi = 10.1093/nar/28.9.1871 }}
*{{cite journal | author=Winchester CL, Ferrier RK, Sermoni A, ''et al.'' |title=Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy. |journal=Hum. Mol. Genet. |volume=8 |issue= 3 |pages= 481-92 |year= 1999 |pmid= 9949207 |doi= }}
* {{cite journal | vauthors = Winchester C, Robertson S, MacLeod T, Johnson K, Thomas M | title = Expression of a homeobox gene (SIX5) in borderline ovarian tumours | journal = J. Clin. Pathol. | volume = 53 | issue = 3 | pages = 212–7 | year = 2000 | pmid = 10823141 | pmc = 1731149 | doi = 10.1136/jcp.53.3.212 }}
*{{cite journal | author=Ohto H, Kamada S, Tago K, ''et al.'' |title=Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6815-24 |year= 2000 |pmid= 10490620 |doi=  }}
* {{cite journal | vauthors = Dintilhac A, Bernués J | title = HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7021–8 | year = 2002 | pmid = 11748221 | doi = 10.1074/jbc.M108417200 }}
*{{cite journal | author=Harris SE, Winchester CL, Johnson KJ |title=Functional analysis of the homeodomain protein SIX5. |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1871-8 |year= 2000 |pmid= 10756185 |doi= }}
* {{cite journal | vauthors = Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K | title = Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1 | journal = Hum. Mol. Genet. | volume = 11 | issue = 9 | pages = 1045–58 | year = 2002 | pmid = 11978764 | doi = 10.1093/hmg/11.9.1045 }}
*{{cite journal | author=Winchester C, Robertson S, MacLeod T, ''et al.'' |title=Expression of a homeobox gene (SIX5) in borderline ovarian tumours. |journal=J. Clin. Pathol. |volume=53 |issue= 3 |pages= 212-7 |year= 2000 |pmid= 10823141 |doi= }}
* {{cite journal | vauthors = Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P | title = Six and Eya expression during human somitogenesis and MyoD gene family activation | journal = J. Muscle Res. Cell. Motil. | volume = 23 | issue = 3 | pages = 255–64 | year = 2003 | pmid = 12500905 | doi = 10.1023/A:1020990825644 }}
*{{cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
* {{cite journal|authorlink13=Huda Zoghbi | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Sato S, Nakamura M, Cho DH, ''et al.'' |title=Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1. |journal=Hum. Mol. Genet. |volume=11 |issue= 9 |pages= 1045-58 |year= 2002 |pmid= 11978764 |doi=  }}
* {{cite journal | vauthors = Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F | title = Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome | journal = Am. J. Hum. Genet. | volume = 80 | issue = 4 | pages = 800–4 | year = 2007 | pmid = 17357085 | pmc = 1852719 | doi = 10.1086/513322 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Fougerousse F, Durand M, Lopez S, ''et al.'' |title=Six and Eya expression during human somitogenesis and MyoD gene family activation. |journal=J. Muscle Res. Cell. Motil. |volume=23 |issue= 3 |pages= 255-64 |year= 2003 |pmid= 12500905 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Hoskins BE, Cramer CH, Silvius D, ''et al.'' |title=Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. |journal=Am. J. Hum. Genet. |volume=80 |issue= 4 |pages= 800-4 |year= 2007 |pmid= 17357085 |doi= 10.1086/513322 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{FactorBook|SIX5}}
 
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
 
 
{{gene-19-stub}}

Latest revision as of 15:45, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.[1][2]

References

  1. ↑ Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL (Apr 1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat". Hum Mol Genet. 4 (10): 1919–25. doi:10.1093/hmg/4.10.1919. PMID 8595416.
  2. ↑ "Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)".

Further reading

External links


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