POU4F1
| POU domain, class 4, transcription factor 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | POU4F1 ; BRN3A; FLJ13449; Oct-T1; RDC-1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 21255 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE POU4F1 206940 s at tn.png | |||||||||||
| File:PBB GE POU4F1 211341 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
POU domain, class 4, transcription factor 1, also known as POU4F1, is a human gene.[1]
BRN3A (POU4F1) is a class IV POU domain-containing transcription factor highly expressed in the developing sensory nervous system and in cells of the B- and T-lymphocytic lineages (Gerrero et al., 1993).[supplied by OMIM][1]
See also
References
Further reading
- Collum RG, Fisher PE, Datta M; et al. (1992). "A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system". Nucleic Acids Res. 20 (18): 4919–25. PMID 1357630.
- Xiang M, Zhou L, Macke JP; et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.
- Bhargava AK, Li Z, Weissman SM (1993). "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10260–4. PMID 8234287.
- Gerrero MR, McEvilly RJ, Turner E; et al. (1993). "Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10841–5. PMID 8248179.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Still IH, Cowell J (1996). "The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis". Cytogenet. Cell Genet. 74 (3): 225–6. PMID 8941380.
- Smith MD, Dawson SJ, Latchman DS (1997). "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor". J. Biol. Chem. 272 (2): 1382–8. PMID 8995448.
- Budhram-Mahadeo V, Parker M, Latchman DS (1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Mol. Cell. Biol. 18 (2): 1029–41. PMID 9448000.
- Frass B, Vassen L, Möröy T (2003). "Gene expression of the POU factor Brn-3a is regulated by two different promoters". Biochim. Biophys. Acta. 1579 (2–3): 207–13. PMID 12427558.
- Thomas GR, Latchman DS (2003). "The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription". Cancer Biol. Ther. 1 (4): 428–32. PMID 12432261.
- Trieu M, Ma A, Eng SR; et al. (2003). "Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a". Development. 130 (1): 111–21. PMID 12441296.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ma L, Lei L, Eng SR; et al. (2003). "Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons". Development. 130 (15): 3525–34. PMID 12810599.
- Sindos M, Ndisang D, Pisal N; et al. (2003). "Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia". Gynecol. Oncol. 90 (2): 366–71. PMID 12893201.
- Sindos M, Ndisang D, Pisal N; et al. (2004). "Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality". Int. J. Gynecol. Cancer. 13 (4): 515–7. PMID 12911730.
- Calissano M, Latchman DS (2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID 12934100.
- Gascoyne DM, Thomas GR, Latchman DS (2004). "The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1". Oncogene. 23 (21): 3830–40. doi:10.1038/sj.onc.1207497. PMID 15021903.
- Farooqui-Kabir SR, Budhram-Mahadeo V, Lewis H; et al. (2005). "Regulation of Hsp27 expression and cell survival by the POU transcription factor Brn3a". Cell Death Differ. 11 (11): 1242–4. doi:10.1038/sj.cdd.4401478. PMID 15272315.
- Ndisang D, Faulkes DJ, Gascoyne D; et al. (2006). "Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a". Oncogene. 25 (1): 51–60. doi:10.1038/sj.onc.1209006. PMID 16247485.
- Diss JK, Faulkes DJ, Walker MM; et al. (2006). "Brn-3a neuronal transcription factor functional expression in human prostate cancer". Prostate Cancer Prostatic Dis. 9 (1): 83–91. doi:10.1038/sj.pcan.4500837. PMID 16276351.
External links
- POU4F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.