NFATC4
| Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NFATC4 ; NF-ATc4; NFAT3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3349 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE NFATC4 213345 at tn.png | |||||||||||
| File:PBB GE NFATC4 205897 at tn.png | |||||||||||
| More reference expression data | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4, also known as NFATC4, is a human gene.[1]
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[1]
See also
References
Further reading
- Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annu. Rev. Immunol. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
- Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. PMID 10089876.
- Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.
- Hoey T, Sun YL, Williamson K, Xu X (1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. PMID 7749981.
- Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". Eur. J. Immunol. 24 (11): 2646–52. PMID 7957556.
- Vacca A, Farina M, Maroder M; et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochem. Biophys. Res. Commun. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.
- Di Somma MM, Majolini MB, Burastero SE; et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". Eur. J. Immunol. 26 (9): 2181–8. PMID 8814265.
- Molkentin JD, Lu JR, Antos CL; et al. (1998). "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy". Cell. 93 (2): 215–28. PMID 9568714.
- Aramburu J, Garcia-Cózar F, Raghavan A; et al. (1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Mol. Cell. 1 (5): 627–37. PMID 9660947.
- Chow CW, Davis RJ (2000). "Integration of calcium and cyclic AMP signaling pathways by 14-3-3". Mol. Cell. Biol. 20 (2): 702–12. PMID 10611249.
- Graef IA, Chen F, Chen L; et al. (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–75. PMID 11439183.
- Yang T, Davis RJ, Chow CW (2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". J. Biol. Chem. 276 (43): 39569–76. doi:10.1074/jbc.M102961200. PMID 11514544.
- Yang TT, Xiong Q, Enslen H; et al. (2002). "Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases". Mol. Cell. Biol. 22 (11): 3892–904. PMID 11997522.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. PMID 12482669.
- Graef IA, Wang F, Charron F; et al. (2003). "Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons". Cell. 113 (5): 657–70. PMID 12787506.
- Lahti AL, Manninen A, Saksela K (2003). "Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB". Virology. 310 (1): 190–6. PMID 12788643.
External links
- NFATC4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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