MAFF (gene)
| V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | MAFF ; U-MAF | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7825 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE MAFF 36711 at tn.png | |||||||||||
| File:PBB GE MAFF 205193 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian), also known as MAFF, is a human gene.[1]
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Two transcript variants encoding the same protein have been found for this gene.[1]
See also
References
Further reading
- Ye X, Li Y, Huang Q; et al. (2006). "The novel human gene MIP functions as a co-activator of hMafF". Arch. Biochem. Biophys. 449 (1–2): 87–93. doi:10.1016/j.abb.2006.02.011. PMID 16549056.
- Massrieh W, Derjuga A, Doualla-Bell F; et al. (2006). "Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells". Biol. Reprod. 74 (4): 699–705. doi:10.1095/biolreprod.105.045450. PMID 16371591.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Marini MG, Asunis I, Chan K; et al. (2003). "Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation". Blood Cells Mol. Dis. 29 (2): 145–58. PMID 12490281.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Moran JA, Dahl EL, Mulcahy RT (2002). "Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators". Biochem. J. 361 (Pt 2): 371–7. PMID 11772409.
- Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M (2001). "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities". J. Biol. Chem. 276 (1): 819–26. doi:10.1074/jbc.M007643200. PMID 11036080.
- Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Kimura T, Ivell R, Rust W; et al. (1999). "Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium". Biochem. Biophys. Res. Commun. 264 (1): 86–92. doi:10.1006/bbrc.1999.1487. PMID 10527846.
- Johnsen O, Skammelsrud N, Luna L; et al. (1996). "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1". Nucleic Acids Res. 24 (21): 4289–97. PMID 8932385.
- Igarashi K, Kataoka K, Itoh K; et al. (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins". Nature. 367 (6463): 568–72. doi:10.1038/367568a0. PMID 8107826.
External links
- MAFF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.