MAFB (gene)
| V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | MAFB ; KRML; MGC43127 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 31315 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE MAFB 218559 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian), also known as MAFB, is a human gene.[1]
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.[1]
References
Further reading
- Cordes SP, Barsh GS (1995). "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor". Cell. 79 (6): 1025–34. PMID 8001130.
- Sieweke MH, Tekotte H, Frampton J, Graf T (1996). "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation". Cell. 85 (1): 49–60. PMID 8620536.
- Stoffel M, Le Beau MM, Espinosa R; et al. (1996). "A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene". Proc. Natl. Acad. Sci. U.S.A. 93 (9): 3937–41. PMID 8632993.
- Wang PW, Eisenbart JD, Cordes SP; et al. (1999). "Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics. 59 (3): 275–81. doi:10.1006/geno.1999.5884. PMID 10444328.
- Li R, Pei H, Watson DK, Papas TS (2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes". Oncogene. 19 (6): 745–53. doi:10.1038/sj.onc.1203385. PMID 10698492.
- Yamada K, Tomita H, Yoshiura K; et al. (2000). "An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12". Eur. J. Hum. Genet. 8 (7): 535–9. doi:10.1038/sj.ejhg.5200485. PMID 10909854.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. PMID 12499396.
- Hashizume H, Hamalainen H, Sun Q; et al. (2004). "Downregulation of mafB expression in T-helper cells during early differentiation in vitro". Scand. J. Immunol. 57 (1): 28–34. PMID 12542795.
- Fernández-Calotti PX, Salamone G, Gamberale R; et al. (2004). "Downregulation of mac-1 expression in monocytes by surface-bound IgG". Scand. J. Immunol. 57 (1): 35–44. PMID 12542796.
- Mechta-Grigoriou F, Giudicelli F, Pujades C; et al. (2003). "c-jun regulation and function in the developing hindbrain". Dev. Biol. 258 (2): 419–31. PMID 12798298.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kim JC, Badano JL, Sibold S; et al. (2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression". Nat. Genet. 36 (5): 462–70. doi:10.1038/ng1352. PMID 15107855.
- Sevinsky JR, Whalen AM, Ahn NG (2004). "Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler". Mol. Cell. Biol. 24 (10): 4534–45. PMID 15121870.
- Petersen HH, Hilpert J, Jacobsen C; et al. (2004). "Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development". FEBS Lett. 565 (1–3): 23–7. doi:10.1016/j.febslet.2004.03.069. PMID 15135046.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Bakri Y, Sarrazin S, Mayer UP; et al. (2005). "Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate". Blood. 105 (7): 2707–16. doi:10.1182/blood-2004-04-1448. PMID 15598817.
- Gemelli C, Montanari M, Tenedini E; et al. (2006). "Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells". Cell Death Differ. 13 (10): 1686–96. doi:10.1038/sj.cdd.4401860. PMID 16456583.
- Lee LC, Zhang AY, Chong AK; et al. (2006). "Expression of a novel gene, MafB, in Dupuytren's disease". The Journal of hand surgery. 31 (2): 211–8. doi:10.1016/j.jhsa.2005.09.007. PMID 16473681.
External links
- MAFB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.