KLF2
| Kruppel-like factor 2 (lung) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KLF2 ; LKLF | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7395 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE KLF2 219371 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Kruppel-like factor 2 (lung), also known as KLF2, is a human gene.[1]
See also
References
Further reading
- Anderson KP, Kern CB, Crable SC, Lingrel JB (1995). "Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family". Mol. Cell. Biol. 15 (11): 5957–65. PMID 7565748.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Kozyrev SV, Hansen LL, Poltaraus AB; et al. (1999). "Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus". FEBS Lett. 448 (1): 149–52. PMID 10217429.
- Wani MA, Conkright MD, Jeffries S; et al. (1999). "cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor". Genomics. 60 (1): 78–86. doi:10.1006/geno.1999.5888. PMID 10458913.
- Conkright MD, Wani MA, Lingrel JB (2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.
- Denkinger DJ, Cushman-Vokoun AM, Kawahara RS (2002). "Regulation of the vav proto-oncogene by LKLF". Gene. 281 (1–2): 133–42. PMID 11750135.
- Dekker RJ, van Soest S, Fontijn RD; et al. (2002). "Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)". Blood. 100 (5): 1689–98. doi:10.1182/blood-2002-01-0046. PMID 12176889.
- Banerjee SS, Feinberg MW, Watanabe M; et al. (2003). "The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis". J. Biol. Chem. 278 (4): 2581–4. doi:10.1074/jbc.M210859200. PMID 12426306.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- SenBanerjee S, Lin Z, Atkins GB; et al. (2004). "KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation". J. Exp. Med. 199 (10): 1305–15. doi:10.1084/jem.20031132. PMID 15136591.
- Haaland RE, Yu W, Rice AP (2005). "Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes". Mol. Immunol. 42 (5): 627–41. doi:10.1016/j.molimm.2004.09.012. PMID 15607822.
- Lin Z, Kumar A, SenBanerjee S; et al. (2005). "Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function". Circ. Res. 96 (5): e48–57. doi:10.1161/01.RES.0000159707.05637.a1. PMID 15718498.
- Wang F, Zhu Y, Huang Y; et al. (2005). "Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis". Oncogene. 24 (24): 3875–85. doi:10.1038/sj.onc.1208546. PMID 15735666.
- Huddleson JP, Ahmad N, Srinivasan S, Lingrel JB (2005). "Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway". J. Biol. Chem. 280 (24): 23371–9. doi:10.1074/jbc.M413839200. PMID 15834135.
- Parmar KM, Nambudiri V, Dai G; et al. (2005). "Statins exert endothelial atheroprotective effects via the KLF2 transcription factor". J. Biol. Chem. 280 (29): 26714–9. doi:10.1074/jbc.C500144200. PMID 15878865.
- Basu P, Morris PE, Haar JL; et al. (2005). "KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo". Blood. 106 (7): 2566–71. doi:10.1182/blood-2005-02-0674. PMID 15947087.
- Bhattacharya R, Senbanerjee S, Lin Z; et al. (2005). "Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2". J. Biol. Chem. 280 (32): 28848–51. doi:10.1074/jbc.C500200200. PMID 15980434.
- Zhang P, Basu P, Redmond LC; et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- Sen-Banerjee S, Mir S, Lin Z; et al. (2006). "Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells". Circulation. 112 (5): 720–6. doi:10.1161/CIRCULATIONAHA.104.525774. PMID 16043642.
External links
- KLF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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